Figure 1. ROC-curves of the WD-DEF-group before therapy and the WD-SUS-group are presented for the following 7 parameters: counts of thrombocytes (thrombocytes), serum albumin (albumin), cholinesterase (CHE), Quick’s test (Quick), ceruloplasmin, hemoglobin and serum copper (Cu (serum)). The largest area under the curve (AUC) was found for CHE.

Figure 1. ROC-curves of the WD-DEF-group before therapy and the WD-SUS-group are presented for the following 7 parameters: counts of thrombocytes (thrombocytes), serum albumin (albumin), cholinesterase (CHE), Quick’s test (Quick), ceruloplasmin, hemoglobin and serum copper (Cu (serum)). The largest area under the curve (AUC) was found for CHE.

Figure 2. Ceruloplasmin (mg/dL) (ordinate) was plotted against cholinesterase (U/L) (absc issa) for the WD-DEF-group (open circles) and the WD-SUS-group (full circles). A linear combination of CHE and ceruloplasmin allowed the separation of the WD-DEF- and WD-SUS-group completely.

Table 1. Main presenting symptoms in the WD-DEF-group (left part) and in the WD-SUS-group (right part).

Table 1. Main presenting symptoms in the WD-DEF-group (left part) and in the WD-SUS-group (right part).

WD-DEF-Group WD-SUS-Group Clinical subgroupn=Main symptomn=Main symptomFinal diagnosisASYMPT1n.a.8n.a.Gene carrierHEP42 patients with reduced
daily activities
1 patient with
intellectual decline
1 patient with acute
hepatic failure11 patient with reduced daily activitiesHepatitisN-TRE7Tremor of extremities and trunk63 patients with symmetric tremor of hands and head
3 patients with asymmetric hand tremorEssential tremor

Idiopathic PD

N-PARK5Symmetric
bradykinesia2Reduced arm swingIdiopathic PDN-OTHMD3Cerebellar ataxia,
Chorea,
generalized dystonia4Psychogenic movement disorderConfirmedN-PAIN0 3Pain in muscles and jointsRheumatism,
joint degeneration,
Complex regional pain syndrome, CRPSN-INFL0 3Paresthesia, spasticityNeuroinflammatory disease (MS, NMO)N-FATIQUE0 2Severe tirednessMS, CFSN-DEGEN0 1Loss of balanceMASN-PSYCH0 1FatigueDepression

Table 2. Comparison of parameters of blood and urine in the WD-DEF- and WD-SUS-group.

Table 2. Comparison of parameters of blood and urine in the WD-DEF- and WD-SUS-group.

Area under ROC-CurveRankParameterWD-DEF
MV/SD
before Therapyp-ValueWD-SUS
MV/SDp-ValueWD-DEF
MV/SD
after TherapyRankArea under ROC-Curve0.971CHE2999/18014.58 × 10−148035/13888.12 × 10−85048/163410.930.932Cerulo10.1/4.11.69 × 10−720.2/6.43.98 × 10−79.7/5.130.910.893Thromb139/571.80 × 10−6249/721.19 × 10−5154/4750.890.884Quick68.3/22.12.36 × 10−593.5/15.42.89 × 10−379.3/17.070.860.825Cu (serum)51.6/27.21.96 × 10−493.0/36.82.49 × 10−735.1/22.120.960.966Cu (24 h)966/12924.42 × 10−431.0/42.51.19 × 10−5160.1/138.140.880.887GPT91.0/95.11.17 × 10−324.0/16.13.38 × 10−247.7/47.1>70.650.95>7Cu (mg/L)519/7531.47 × 10−324.5/44.86.76 × 10−4113.3/121.260.86