JCM, Vol. 11, Pages 7060: Pharmacological Interventions for Opioid-Induced Hyperalgesia: A Scoping Review of Preclinical Trials

Dunbar et al. (2000) [52]Ibuprofen(1) Saline, (2) morphine, (3) morphine and ibuprofen 136 nM, (4) morphine and ibuprofen 13.6 nM, (5) morphine and ibuprofen 1.36 nM #136 nM, 13.6 nM, 1.36 nM in 10 μL bolus via spinal catheterCCrain and Shein (2001) [76]Naltrexone (1) Saline, (2) morphine 1 μg/kg, (3) naltrexone 1 ng/kg and morphine 1 μg/kg, (4) morphine 0.1 μg/kg, (5) naltrexone 1 pg/kg and morphine 0.1 μg/kg 1 ng/kg, 1 pg/kg injectionARaghavendra et al. (2004) [47]Propentofylline (1) Saline, (2) morphine, (3) morphine and propentofylline 1 μg, (4) morphine and propentofylline 10 μg1 μg, 10 μg i.t. daily for 5 daysCDogrul et al. (2005) [48]Amlodipine (1) Saline, (2) morphine, (3) amlodipine and morphine10 μg i.t. twice a day for 8 daysCVan Elstraete et al. (2005) [77]Ketamine (1) Saline, (2) morphine, (2) ketamine and morphine10 mg/kg s.c.AJuni et al. (2006) [78]MK-801(1) Placebo pellets and morphine, (2) placebo pellets and MK-801 and morphine0.05 mg/kg MK-801 s.c.CDunbar et al. (2007) [44]Ketorolac (1) Saline, (2) morphine, (3) morphine and ketorolac, (4) morphine and naloxone, (5) morphine and ketorolac and naloxone5 mg/kg s.c. daily for 4 daysCEsmaeili-Mahani et al. (2007) [79]Nifedipine (1) Vehicle, (2) morphine 1 μg/kg, (3) nifedipine 2 mg/kg and morphine 1 μg/kg, (4) morphine 0.01 μg/kg, (5) nifedipine 10 μg/kg and morphine 0.01 μg/kg2 mg/kg i.p., 10 μg/kg i.t.ATumati et al. (2008) [55]Raf-1 siRNA(1) Vehicle, (2) morphine, (3) morphine and non-targeting dsRNA, (4) morphine and Raf-1 siRNA2 µg i.t. once a day for 3 daysCEsmaeili-Mahani et al. (2010) [80]Olive leaf extract (1) Vehicle, (2) morphine, (3) morphine and OLE 6 mg/kg, (4) morphine and OLE 12 mg/kg6 mg/kg, 12 mg/kg i.p.ATumati et al. (2010) [49]Raf-1 siRNA(1) Vehicle, (2) morphine, (3) non-targeting dsRNA and morphine, (4) Raf-1 siRNA and morphine2 µg i.t. once a day for 3 daysCGupta et al. (2011) [81]Magnesium or dextromethorphan or d-serine (1) Saline, (2) morphine, (3) morphine and magnesium 2 mg/kg, (4) morphine and magnesium 5 mg/kg, (5) morphine and dextromethorphan 2 mg/kg, (6) morphine and dextromethorphan 5 mg/kg, (7) morphine and dextromethorphan 10 mg/kg, (8) morphine and d-serine 2 mg/kg, (9) morphine and d-serine 5 mg/kg, (10) morphine and d-serine 10 mg/kgMagnesium: 2 mg/kg, 5 mg/kg i.p. Dextromethorphan: 2 mg/kg, 5 mg/kg, 10 mg/kg i.p. D-serine: 2 mg/kg, 5 mg/kg, 10 mg/kg i.p.ALiang et al. (2011) [82]Ondansetron (1) Morphine, (2) morphine and ondansetron s.c., (3) morphine and ondansetron s.c. twice a day for 4 days, (4) morphine and ondansetron i.t., (5) morphine and ondansetron 1 μg peripheral injection #, (6) morphine and ondansetron 10 μg peripheral injection #2 mg/kg s.c. or 1 mg/kg s.c. twice a day for 4 days or 1 μg i.t. or 1 μg, 10 μg peripheral hind paw injectionCTumati et al. (2011) [56]PKA siRNA(1) Vehicle, (2) morphine, (3) PKA siRNA and morphine2 µg i.t. once a day for 3 daysCChen et al. (2012) [45]Ceftriaxone(1) Saline, (2) morphine, (3) ceftriaxone and morphine200 mg/kg i.p. daily for 7 daysCTumati et al. (2012) [83]L-732,138 (1) Saline, (2) morphine, (3) morphine and L-732,13820 μg/5 μL i.t. twice a day for 6 daysCWei and Wei (2012) [20]Gabapentin (1) Saline, (2) morphine, (3) gabapentin 25 mg/kg and morphine, (4) gabapentin 50 mg/kg and morphine25 mg/kg, 50 mg/kg i.p.CXin et al. (2012) [84]Melatonin (1) Saline, (2) morphine, (3) morphine and melatonin 25 mg/kg #, (4) morphine and melatonin 50 mg/kg, (5) morphine and melatonin 100 mg/kg25 mg/kg, 50 mg/kg, 100 mg/kg i.g. once a day for 7 daysCMilne et al. (2013) [46]Efaroxan or atipamezole or yohimbine (1) Saline, (2) morphine, (3) morphine and (+) efaroxan, (4) morphine and (-) efaroxan #, (5) morphine and atipamezole, (6) morphine and yohimbineEfaroxan: 1.3 ng i.t. Atipamezole: 0.08 ng i.t. Yohimbine: 0.02 ng i.t.AOrrù et al. (2014) [85]Withania somnifera root extract (1) Saline, (2) morphine, (3) WSE and morphine100 mg/kg i.p.ALi et al. (2014) [86]Re or Rg1 or Rb1 ginsenosides(1) Saline, (2) morphine, (3) morphine and Re 100 mg/kg #, (4) morphine and Re 200 mg/kg #, (5) morphine and Re 300 mg/kg, (6) morphine and Rg1 100 mg/kg #, (7) morphine and Rg1 200 mg/kg #, (8) morphine and Rg1 300 mg/kg #, (9) morphine and 100 mg/kg Rb1 #, (10) morphine and Rg1 200 mg/kg #, (11) morphine and Rg1 300 mg/kg #100 mg/kg, 200 mg/kg, 300 mg/kg i.g. twice a day for 2 daysCSanna et al. (2015) [50]CTOP or PD98059 (1) Saline, (2) morphine, (3) morphine and CTOP, (4) PD98059 and morphinePD98059: 20 µg i.t. CTOP: 0.1 mg i.t.ASong et al. (2015) [87]Melatonin (1) Saline, (2) morphine, (3) morphine and melatonin10 mg/kg i.p.CHu et al. (2016) [88]PLGA curcumin nanoformulation or unformulated curcumin(1) Vehicle i.t., (2) morphine, (3) morphine and unformulated curcumin [6], (4) vehicle oral, (5) morphine and PLGA curcumin 2 mg/kg #, (6) morphine and PLGA curcumin 6 mg/kg, (7) morphine and PLGA curcumin 20 mg/kg Unformulated curcumin: 30 μg i.t. PLGA curcumin: 2 mg/kg, 6 mg/kg, 20 mg/kg oral administration.CHua et al. (2016) [57]MSC(1) Saline, (2) morphine, (3) MSC i.t. 1 day before and morphine, (4) MSC i.v. 1 day before and morphine, (5) MSC i.t. 7 day before and morphine, (6) MSC i.v. 7 day before and morphine, (7) morphine and MSC i.t. on day 14, (8) morphine and MSC i.v. on day 140.5 million MSCs i.t. or 0.5 million MSCs i.v.CCorder et al. (2017) [53]Methylnaltrexone bromide (1) Saline, (2) morphine, (3) morphine and methylnaltrexone bromide 10 mg/kg s.c. once a day for 7 daysCFerrini et al. (2017) [54]CLP257 or CLP290 (1) Saline, (2) morphine, (3) morphine and CLP290, (4) morphine and CLP257 on day 9, (5) morphine and CLP257 on day 7 and 8CLP290: 100 mg/kg orally twice a day for 7 days. CLP257: 100 mg/kg i.p. on day 7 and 8 or only day 9CHaleem and Nawas (2017) [51]Buspirone (1) Saline, (2) morphine, (3) morphine and buspirone 1 mg/kg, (4) morphine and buspirone 2 mg/kg1 mg/kg or 2 mg/kg i.p.CDatta et al. (2020) [89]DAMGO or GAT211 (1) Saline, (2) morphine, (3) morphine and DAMGO 0.03 μg, (4) morphine and DAMGO 0.1 μg, (5) morphine and DAMGO 0.3 μg, (6) morphine and DAMGO 1 μg, (7) morphine and GAT211 1 μg #, (8) morphine and GAT211 1 μg #, (9) morphine and GAT211 5 μg #, (10) morphine and GAT211 10 μg #, (11) morphine and GAT211 20 μg #DAMGO: 0.03 μg, 0.1 μg, 0.3 μg, 1 μg. GAT211: 1 μg, 5 μg, 10 μg, 20 μgCDoyle et al. (2020) [27]W146 or JTE-013 or CAY10444 or NIBR-14 or SEW2871 or S1pr1 siRNA or NIBR-15 or fingolimod or ponesimod (1) Saline, (2) morphine, (3) morphine and W140, (4) morphine and W146 0.2 nmol/day, (5) morphine and W146 0.7 nmol/day, (6) morphine and W146 2 nmol/day, (7) morphine and JTE-013 #, (8) morphine and CAY1044 #, (9) morphine and NIBR-14 i.t. 3 nmol/day, (10) morphine and SEW2871 2 nmol/day #, (11) morphine and SEW2871 20 mg/kg/day #, (12) morphine and non-targeting siRNA, (13) morphine and S1pr1 siRNA, (14) morphine and oral NIBR-14 0.3 mg/kg/day #, (15) morphine and oral NIBR-14 1 mg/kg/day, (16) morphine and oral NIBR-14 3 mg/kg/day, (17) morphine and oral NIBR-15 3 mg/kg/day, (18) morphine and fingolimod 0.03 mg/kg/day #, (19) morphine and fingolimod 0.01 mg/kg/day, (20) morphine and fingolimod 0.1 mg/kg/day male rats, (21) morphine and fingolimod 0.1 mg/kg/day female rats, (22) morphine and ponesimod, (23) CCI and saline and vehicle, (24) CCI and morphine and vehicle, 25) CCI and morphine and fingolimodW146: 0.2 nmol/day, 0.7 nmol/day, 2 nmol/day. JTE-013: 2 nmol/day. CAY1044: 2 nmol/day. NIBR-14: 3 nmol/day i.t., 0.3 mg/kg/day oral, 1 mg/kg/day oral, 3 mg/kg/day. NIBR-15: 3 mg/kg/day oral. SEW2871: 2 nmol/day i.t., 20 mg/kg/day i.p. S1pr1 siRNA: 2 μg i.t. Fingolimod: 0.03 mg/kg/day oral, 0.01 mg/kg/day oral, 0.1 mg/kg/day oral. Ponesimod: 3 mg/kg/day. CLin et al. (2020) [58]TUDCA or AEBSF or 4μ8C or salubrinal or adenovirus-HSP70 or glibenclamide(1) Vehicle, (2) morphine, (3) TUDCA and morphine, (4) AEBSF and morphine, (5) 4μ8C and morphine, (6) salubrinal and morphine #, (7) adenovirus-HSP70 and morphine, (8) glibenclamide 0.08 μg and morphine, (9) glibenclamide 0.4 μg and morphine, (10) glibenclamide 2 μg and morphineTUDCA: 100 μg/10 μL i.t. Glibenclamide or TUDCA or AEBSF or 4μ8C or salubrinal or adenovirus-HSP70. Glibenclamide: 0.08 μg, 0.4 μg, 2 μg. C

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