Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, et al. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst). 2007;6:1243–54.

Article  CAS  PubMed  Google Scholar 

Bartova E, Legartova S, Dundr M, Suchankova J. A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair. Aging (Albany NY). 2019;11:2488–511.

Article  CAS  PubMed  Google Scholar 

Blanpain C, Mohrin M, Sotiropoulou PA, Passegue E. DNA-damage response in tissue-specific and cancer stem cells. Cell Stem Cell. 2011;8:16–29.

Article  CAS  PubMed  Google Scholar 

Chatterjee N, Walker GC. Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen. 2017;58:235–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong CM, Wang XL, Wang GM, Zhang WJ, Zhu L, Gao S, Yang DJ, Qin Y, Liang QJ, Chen YL, et al. A stress-induced cellular aging model with postnatal neural stem cells. Cell Death Dis. 2014;5:e1116.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Georgoulis A, Vorgias CE, Chrousos GP, Rogakou EP. Genome instability and γH2AX. Int J Mol Sci. 2017;18(9):1979. https://doi.org/10.3390/ijms18091979.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh R, Das D, Franco S. The role for the DSB response pathway in regulating chromosome translocations. Adv Exp Med Biol. 2018;1044:65–87.

Article  CAS  PubMed  Google Scholar 

Gunes S, Al-Sadaan M, Agarwal A. Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility. Reprod Biomed Online. 2015;31:309–19.

Article  CAS  PubMed  Google Scholar 

Habas K, Brinkworth MH, Anderson D. Diethylstilbestrol induces oxidative DNA damage, resulting in apoptosis of spermatogonial stem cells in vitro. Toxicology. 2017;382:117–21.

Article  CAS  PubMed  Google Scholar 

Hamer G, Roepers-Gajadien HL, van Duyn-Goedhart A, Gademan IS, Kal HB, van Buul PP, de Rooij DG. DNA double-strand breaks and gamma-H2AX signaling in the testis. Biol Reprod. 2003;68:628–34.

Article  CAS  PubMed  Google Scholar 

Her J, Ray C, Altshuler J, Zheng H, Bunting SF. 53BP1 mediates ATR-Chk1 signaling and protects replication forks under conditions of replication stress. Mol Cell Biol. 2018;38(8):e00472-17. https://doi.org/10.1128/MCB.00472-17.

Article  PubMed  PubMed Central  Google Scholar 

Kanatsu-Shinohara M, Ogonuki N, Inoue K, Miki H, Ogura A, Toyokuni S, Shinohara T. Long-term proliferation in culture and germline transmission of mouse male germline stem cells. Biol Reprod. 2003;69:612–6.

Article  CAS  PubMed  Google Scholar 

Le W, Qi L, Xu C, Xiang Z, Mao Z, Zhang J, Xu J, Wu D. Preliminary study of the homologous recombination repair pathway in mouse spermatogonial stem cells. Andrology. 2018;6:488–97.

Article  CAS  PubMed  Google Scholar 

Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A. 2007;104:13068–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marjault HB, Allemand I. Consequences of irradiation on adult spermatogenesis: between infertility and hereditary risk. Mutat Res. 2016;770:340–8.

Article  CAS  Google Scholar 

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, et al. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016;214:155–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parnandi N, Rendo V, Cui G, Botuyan MV, Remisova M, Nguyen H, Drane P, Beroukhim R, Altmeyer M, Mer G, et al. TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs. Mol Cell. 2021;81(2583–2595):e2586.

Google Scholar 

Rube CE, Zhang S, Miebach N, Fricke A, Rube C. Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells. DNA Repair (Amst). 2011;10:159–68.

Article  PubMed  Google Scholar 

Sabatella M, Thijssen KL, Davo-Martinez C, Vermeulen W, Lans H. Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1. Cell Rep. 2021;34:108608.

Article  CAS  PubMed  Google Scholar 

Singh P, Aggarwal LM, Parry SA, Raman MJ. Radiation dosimetry and repair kinetics of DNA damage foci in mouse pachytene spermatocyte and round spermatid stages. Mutagenesis. 2018;33:231–9.

Article  CAS  PubMed  Google Scholar 

Sun S, Osterman MD, Li M. Tissue specificity of DNA damage response and tumorigenesis. Cancer Biol Med. 2019;16:396–414.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vallabhaneni H, Lynch PJ, Chen G, Park K, Liu Y, Goehe R, Mallon BS, Boehm M, Hursh DA. High basal levels of gammaH2AX in human induced pluripotent stem cells are linked to replication-associated DNA damage and repair. Stem Cells. 2018;36:1501–13.

Article  CAS  PubMed  Google Scholar 

van Jaarsveld MTM, Deng D, Wiemer EAC, Zi Z. Tissue-specific Chk1 activation determines apoptosis by regulating the balance of p53 and p21. iScience. 2019;12:27–40.

Article  PubMed  PubMed Central  Google Scholar 

West SC, Chan YW. Genome instability as a consequence of defects in the resolution of recombination intermediates. Cold Spring Harb Symp Quant Biol. 2017;82:207–12. https://doi.org/10.1101/sqb.2017.82.034256.

Article  PubMed  Google Scholar 

Yang J, Jing L, Liu CJ, Bai WW, Zhu SC. 53BP1 regulates cell cycle arrest in esophageal cancer model. Eur Rev Med Pharmacol Sci. 2019;23:604–12.

CAS  PubMed  Google Scholar 

Yao J, Huang A, Zheng X, Liu T, Lin Z, Zhang S, Yang Q, Zhang T, Ma H. 53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway. J Cancer Res Clin Oncol. 2017;143:419–31.

Article  CAS  PubMed  Google Scholar