SARS-CoV-2 down-regulates ACE2 through lysosomal degradation

We thank James H. Hurley for providing cDNAs of the AP2 complex and Nevan Krogan for the pLVX-IRES-Puro construct; Suifang Mao for technical assistance and helpful advice on immunohistochemistry analysis of lung tissue and imaging; and Qiang Zhou for helpful suggestions and discussions. We are also grateful to the Centers for Disease Control and Prevention (Atlanta, GA), the California Department of Public Health (Richmond, CA), and Catherine Blish, Stanford University School of Medicine, for providing SARS-CoV-2 strains. This study was supported by the COVID-19 Catalyst Fund from the Center for Emerging and Neglected Diseases at UC Berkeley to K.L. and by the Fast Grants, a part of Emergent Ventures, a project of the Mercatus Center at George Mason University, to S.A.S. Y.L. is supported by the Berkeley Scholars program.

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