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The ability to modulate what enters and exits living cells is a key goal of the biological sciences. The development of new delivery platforms for cargo molecules, such as cell-penetrating peptides (CPPs), has captured a lot of attention, but so far, endocytosis has only been induced with positively charged CPPs. Now, Kai Chen, Min Xue and co-workers have developed a new category of effective CPPs, rich in hydroxyl groups and with no positive charge, opening up a new avenue for drug delivery vehicles.

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