Granito A, Guidetti E, Gramantieri L. c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma. J Hepatocell Carcinoma. 2015;2:29–38. https://doi.org/10.2147/JHC.S77038
Article PubMed PubMed Central Google Scholar
Gentile A, Trusolino L, Comoglio PM. The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev. 2008;27:85–94. https://doi.org/10.1007/s10555-007-9107-6
Article CAS PubMed Google Scholar
Kim ES, Salgia R. MET pathway as a therapeutic target. J Thorac Oncol. 2009;4:444–7. https://doi.org/10.1097/JTO.0b013e31819d6f91
Article PubMed PubMed Central Google Scholar
Zhang Y, Xia M, Jin K, Wang S, Wei H, Fan C, Wu Y, Li X, Li X, Li G, Zeng Z, Xiong W. Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities. Mol Cancer. 2018;17:45 https://doi.org/10.1186/s12943-018-0796-y
Article CAS PubMed PubMed Central Google Scholar
Ghiso E, Giordano S. Targeting MET: why, where and how. Curr Opin Pharm. 2013;13:511–8. https://doi.org/10.1016/j.coph.2013.05.018
Fu J, Su X, Li Z, Deng L, Liu X, Feng X, Peng J. HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence. Oncogene. 2021;40:4625–51. https://doi.org/10.1038/s41388-021-01863-w
Article CAS PubMed Google Scholar
Parikh PK, Ghate MD. Recent advances in the discovery of small molecule c-Met Kinase inhibitors. Eur J Med Chem. 2018;143:1103–38. https://doi.org/10.1016/j.ejmech.2017.08.044
Article CAS PubMed Google Scholar
Ko B, He T, Gadgeel S, Halmos B. MET/HGF pathway activation as a paradigm of resistance to targeted therapies. Ann Transl Med. 2017;5:4. https://doi.org/10.21037/atm.2016.12.09
Article CAS PubMed PubMed Central Google Scholar
Botting GM, Rastogi I, Chhabra G, Nlend M, Puri N. Mechanism of resistance and novel targets mediating resistance to EGFR and c-Met tyrosine kinase inhibitors in non-small cell lung cancer. PLoS One. 2015;10:e0136155. https://doi.org/10.1371/journal.pone.0136155
Article CAS PubMed PubMed Central Google Scholar
Constantinescu T, Lungu CL. Anticancer activity of natural and synthetic chalcones. Int J Mol Sci. 2021;22:11306 https://doi.org/10.3390/ijms222111306
Article CAS PubMed PubMed Central Google Scholar
Oh HN, Lee MH, Kim E, Yoon G, Chae JI, Shim JH. Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET. Phytomedicine. 2019;63:153014. https://doi.org/10.1016/j.phymed.2019.153014
Article CAS PubMed Google Scholar
Jung SK, Lee MH, Lim DY, Lee SY, Jeong CH, Kim JE, Lim TG, Chen H, Bode AM, Lee HJ, Lee KW, Dong Z. Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. Mol Carcinog. 2015;54:322–31. https://doi.org/10.1002/mc.22191
Article CAS PubMed Google Scholar
Salehi B, Varoni EM, Sharifi-Rad M, Rajabi S, Zucca P, Iriti M, Sharifi-Rad J. Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis. Phytomedicine. 2019;55:125–36. https://doi.org/10.1016/j.phymed.2018.07.001
Article CAS PubMed Google Scholar
Oh HN, Lee MH, Kim E, Kwak AW, Yoon G, Cho SS, Liu K, Chae JI, Shim JH. Licochalcone D induces ROS-dependent apoptosis in gefitinib-sensitive or resistant lung cancer cells by targeting EGFR and MET. Biomolecules. 2020;10:297. https://doi.org/10.3390/biom10020297
Article CAS PubMed PubMed Central Google Scholar
Purnama A, Mardina V, Puspita K, et al. Molecular docking of two cytotoxic compounds from Calotropis gigantea leaves against therapeutic molecular target of pancreatic cancer. Narra J. 2021;1. https://doi.org/10.52225/narraj.v1i2.37
Begum S, Bharathi K, Prasad KVSRG. Mini review on therapeutic profile of phenoxy acids and thier derivatives. Int J Pharm Pharm Sci. 2016;8:66–71. https://doi.org/10.22159/ijpps.2016v8i10.5005
Rani P, Pal D, Hegde RR, Hashim SR. Leuckart synthesis and pharmacological assessment of novel acetamide derivatives. Anticancer Agents Med Chem. 2016;16:898–906. https://doi.org/10.2174/1871520616666151111115327
Article CAS PubMed Google Scholar
Patil V, Tilekar K, Mehendale-Munj S, Mohan R, Ramaa CS. Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2,4-thiazolidinedione derivatives. Eur J Med Chem. 2010;45:4539–44. https://doi.org/10.1016/j.ejmech.2010.07.014
Article CAS PubMed Google Scholar
Bhanushali U, Rajendran S, Sarma K, Kulkarni P, Chatti K, Chatterjee S, Ramaa CS. 5-Benzylidene-2,4-thiazolidenedione derivatives: design, synthesis and evaluation as inhibitors of angiogenesis targeting VEGR-2. Bioorg Chem. 2016;67:139–47. https://doi.org/10.1016/j.bioorg.2016.06.006
Article CAS PubMed Google Scholar
Prabhakar BT, Khanum SA, Shashikanth S, Salimath BP. Antiangiogenic effect of 2-benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1 alpha and down regulation of VEGF of in-vivo. Investig N Drugs. 2006;24:471–78. https://doi.org/10.1007/s10637-006-6587-0
Wang C, Gao H, Dong J, Wang F, Li P, Zhang J. Insight into the medicinal chemistry of EGFR and HER-2 inhibitors. Curr Med Chem. 2014;21:1336–50. https://doi.org/10.2174/0929867320666131119124646
Article CAS PubMed Google Scholar
Lee K, Roh SH, Xia Y, Kang KW. Synthesis and biological evaluation of phenoxy-N-phenylacetamide derivatives as novel P-glycoprotein inhibitors. Bull Korean Chem Soc. 2011;32:3666–74. https://doi.org/10.5012/bkcs.2011.32.10.3666
Jung SK, Lee MH, Lim DY, Lee SY, Jeong CH, Kim JE, Lim TG, Chen H, Bode AM, Lee HJ, Lee KW. Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib‐resistant lung cancer growth. Mol Carcinog. 2015;54:322–31. https://doi.org/10.1002/mc.22191
Article CAS PubMed Google Scholar
Joshi A, Bhojwani H, Wagal O, Begwani K, Joshi U, Sathaye S, Kanchan D. Evaluation of benzamide-chalcone derivatives as EGFR/CDK2 inhibitor: synthesis, in-vitro inhibition, and molecular modeling studies. Anticancer Agents Med Chem. 2022;22:328–43. https://doi.org/10.2174/1871520621666210415091359
Article CAS PubMed Google Scholar
Karthikeyan C, Narayana Moorthy NSH, Ramasamy S, Vanam U, Manivannan E, Karunagaran D, Trivedi P. Advances in chalcones with anticancer activities. Recent Pat Anticancer Drug Discov 2014;10:97–115
Silverstein RM, Webster FX. Spectrometric identification of organic compounds, 6th ed. 2006
Parr C, Jiang WG. Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. Int J Oncol. 2001;19:857–63. https://doi.org/10.3892/ijo.19.4.857
Article CAS PubMed Google Scholar
Wang J, Anderson MG, Oleksijew A, Vaidya KS, Boghaert ER, Tucker L, Zhang Q, Han EK, Palma JP, Naumovski L, Reilly EB. ABBV-399, a c-Met antibody-drug conjugate that targets both MET-amplified and c-Met-overexpressing tumors, irrespective of MET pathway dependence. Clin Cancer Res. 2017;23:992–1000. https://doi.org/10.1158/1078-0432.CCR-16-1568
Article CAS PubMed Google Scholar
Kammula US, Kuntz EJ, Francone TD, Zeng Z, Shia J, Landmann RG, Paty PB, Weiser MR. Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett. 2007;248:219–28. https://doi.org/10.1016/j.canlet.2006.07.007
Article CAS PubMed Google Scholar
Liu Y, Shi QF, Qi M, Tashiro S, Onodera S, Ikejima T. Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways. Biol Pharm Bull. 2012;35:1150–58. https://doi.org/10.1248/bpb.b12-00197
Article CAS PubMed Google Scholar
Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA, Hansen M, Schaefer E, Naoki K, Lader A, Richards W, Sugarbaker D, Husain AN, Christensen JG, Salgia R. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res. 2005;65:1479–88. https://doi.org/10.1158/0008-5472.CAN-04-2650
Article CAS PubMed Google Scholar
Humphrey PA, Zhu X, Zarnegar R, Swanson PE, Ratliff TL, Vollmer RT, Day ML. Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Am J Pathol. 1995;147:386–96.
CAS PubMed PubMed Central Google Scholar
Wu JF, Liu MM, Huang SX, Wang Y. Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461. Bioorg Med Chem Lett. 2015;25:3251–55. https://doi.org/10.1016/j.bmcl.2015.05.082
Article CAS PubMed Google Scholar
Yang Y, Zhang Y, Yang L, Zhao L, Si L, Zhang H, Liu Q, Zhou J. Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. Bioorg Chem. 2017;70:126–32. https://doi.org/10.1016/j.bioorg.2016.12.002
Article CAS PubMed Google Scholar
Zhai X, Bao G, Wang L, Cheng M, Zhao M, Zhao S, Zhou H, Gong P. Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors. Bioorg Med Chem. 2016;24:1331–45. https://doi.org/10.1016/j.bmc.2016.02.003
留言 (0)