Abdel-Rahman A, Anyangwe N, Carlacci L, Casper S, Danam RP, Enongene E, Erives G, Fabricant D, Gudi R, Hilmas CJ, Hines F, Howard P, Levy D, Lin Y, Moore RJ, Pfeiler E, Thurmond TS, Turujman S, Walker NJ. The safety and regulation of natural products used as foods and food ingredients. Toxicol Sci. 2011;123(2):333–48.

CAS  PubMed  Google Scholar 

Ahmed HA, Ali HA, Mutar TF. Protective effects of olive leaf extract against reproductive toxicity of the lead acetate in rats. Environ Sci Pollut Res Int. 2021;28(44):63102–10.

Ahn SH, Monsanto SP, Miller C, Singh SS, Thomas R, Tayade C. Pathophysiology and immune dysfunction in endometriosis. Biomed Res Int. 2015;2015: 795976.

PubMed  PubMed Central  Google Scholar 

An KC. Selective estrogen receptor modulators. Asian Spine J. 2016;10(4):787–91.

PubMed  PubMed Central  Google Scholar 

Atanaskova N, Keshamouni VG, Krueger JS, Schwartz JA, Miller F, Reddy KB. MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene. 2002;21(25):4000–8.

CAS  PubMed  Google Scholar 

Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis? Fertil Steril. 2006;85(5):1307–18.

CAS  PubMed  Google Scholar 

Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW. QuPath: open source software for digital pathology image analysis. Sci Rep. 2017;7(1):16878.

PubMed  PubMed Central  Google Scholar 

Bilotas MA, Olivares CN, Ricci AG, Baston JI, Bengochea TS, Meresman GF, Barañao RI. Interplay between endometriosis and pregnancy in a mouse model. PLoS ONE. 2015;10(4):e0124900–e0124900.

PubMed  PubMed Central  Google Scholar 

Borjan D, Leitgeb M, Knez Ž, Hrnčič MK. Microbiological and antioxidant activity of phenolic compounds in olive leaf extract. Molecules (Basel, Switzerland). 2020;25(24):5946.

Boss A, Bishop KS, Marlow G, Barnett MP, Ferguson LR. Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients. 2016;8(8):513.

Brosens I, Derwig I, Brosens J, Fusi L, Benagiano G, Pijnenborg R. The enigmatic uterine junctional zone: the missing link between reproductive disorders and major obstetrical disorders? Hum Reprod. 2010;25(3):569–74.

PubMed  Google Scholar 

Brosens JJ, Hayashi N, White JO. Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells. Endocrinology. 1999;140(10):4809–20.

CAS  PubMed  Google Scholar 

Bulun SE. Endometriosis. N Engl J Med. 2009;360(3):268–79.

CAS  PubMed  Google Scholar 

Bulun SE, Cheng YH, Pavone ME, Yin P, Imir G, Utsunomiya H, Thung S, Xue Q, Marsh EE, Tokunaga H, Ishikawa H, Kurita T, Su EJ. 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. Semin Reprod Med. 2010;28(1):44–50.

CAS  PubMed  PubMed Central  Google Scholar 

Burns KA, Rodriguez KF, Hewitt SC, Janardhan KS, Young SL, Korach KS. Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology. 2012;153(8):3960–71.

CAS  PubMed  PubMed Central  Google Scholar 

Buxani N, Mehta D, Gupta M, Mehta B. Natural products: source of potential drugs. Afr JBasic Appl Sci. 2014;6(6):171–86.

Google Scholar 

Casamenti F, Stefani M. Olive polyphenols: new promising agents to combat aging-associated neurodegeneration. Expert Rev Neurother. 2017;17(4):345–58.

CAS  PubMed  Google Scholar 

Cruz-Lozano M, González-González A, Marchal JA, Muñoz-Muela E, Molina MP, Cara FE, Brown AM, García-Rivas G, Hernández-Brenes C, Lorente JA, Sanchez-Rovira P, Chang JC, Granados-Principal S. Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways. Eur J Nutr. 2019;58(8):3207–19.

CAS  PubMed  Google Scholar 

de Bock M, Thorstensen EB, Derraik JG, Henderson HV, Hofman PL, Cutfield WS. Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Mol Nutr Food Res. 2013;57(11):2079–85.

CAS  PubMed  Google Scholar 

Dodds KN, Beckett EAH, Evans SF, Hutchinson MR. Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally invasive model of endometriosis. Biol Reprod. 2017;97(6):810–21.

PubMed  Google Scholar 

Duong BN, Elliott S, Frigo DE, Melnik LI, Vanhoy L, Tomchuck S, Lebeau HP, David O, Beckman BS, Alam J, Bratton MR, McLachlan JA, Burow ME. AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. Can Res. 2006;66(17):8373–81.

CAS  Google Scholar 

Ebert AD, Bartley J, David M. Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: new questions–old answers? Eur J Obstet Gynecol Reprod Biol. 2005;122(2):144–50.

CAS  PubMed  Google Scholar 

Euhus DM, Hudd C, LaRegina MC, Johnson FE. Tumor measurement in the nude mouse. J Surg Oncol. 1986;31(4):229–34.

CAS  PubMed  Google Scholar 

Fazleabas AT, Brudney A, Chai D, Langoi D, Bulun SE. Steroid receptor and aromatase expression in baboon endometriotic lesions. Fertil Steril. 2003;80(Supplement 2(0)):820–7.

PubMed  Google Scholar 

Ferrero S, Gillott DJ, Venturini PL, Remorgida V. Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review. Reprod Biol Endocrinol RB&E. 2011;9:89.

Google Scholar 

Fu S, Arráez-Roman D, Segura-Carretero A, Menéndez JA, Menéndez-Gutiérrez MP, Micol V, Fernández-Gutiérrez A. Qualitative screening of phenolic compounds in olive leaf extracts by hyphenated liquid chromatography and preliminary evaluation of cytotoxic activity against human breast cancer cells. Anal Bioanal Chem. 2010;397(2):643–54.

CAS  PubMed  Google Scholar 

Fujimoto J, Hirose R, Sakaguchi H, Tamaya T. Expression of oestrogen receptor-α and -β in ovarian endometriomata. Mol Hum Reprod. 1999;5(8):742–7.

CAS  PubMed  Google Scholar 

Gellersen B, Brosens J. Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair. J Endocrinol. 2003;178(3):357–72.

CAS  PubMed  Google Scholar 

Hagiwara K, Goto T, Araki M, Miyazaki H, Hagiwara H. Olive polyphenol hydroxytyrosol prevents bone loss. Eur J Pharmacol. 2011;662(1):78–84.

CAS  PubMed  Google Scholar 

Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O’Malley BW. Estrogen receptor beta modulates apoptosis complexes and the inflammasome to drive the pathogenesis of endometriosis. Cell. 2015;163(4):960–74.

CAS  PubMed  PubMed Central  Google Scholar 

Han SJ, Lee JE, Cho YJ, Park MJ, O’Malley BW. Genomic function of estrogen receptor β in endometriosis. Endocrinology. 2019;160(11):2495–516.

CAS  PubMed  PubMed Central  Google Scholar 

Hartz AM, Madole EK, Miller DS, Bauer B. Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J Pharmacol Exp Ther. 2010;334(2):467–76.

CAS  PubMed  PubMed Central  Google Scholar 

Hioki T, Tokuda H, Kuroyanagi G, Kim W, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O. Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: suppression of Akt and p44/p42 MAP kinase signaling pathways. Biomed Pharmacother. 2021;141: 111816.

CAS  PubMed  Google Scholar 

Hsu I, Chuang K-L, Slavin S, Da J, Lim W-X, Pang S-T, O’Brien JH, Yeh S. Suppression of ERβ signaling via ERβ knockout or antagonist protects against bladder cancer development. Carcinogenesis. 2014;35(3):651–61.

CAS  PubMed  Google Scholar 

Juhasz-Boss I, Fischer C, Lattrich C, Skrzypczak M, Malik E, Ortmann O, Treeck O. Endometrial expression of estrogen receptor beta and its splice variants in patients with and without endometriosis. Arch Gynecol Obstet. 2011;284(4):885–91.

PubMed  Google Scholar 

Karaman K, Pala EE, Bayol U, Akman O, Olmez M, Unluoglu S, Ozturk S. Endometriosis of the terminal ileum: a diagnostic dilemma. Case Rep Pathol. 2012;2012: 742035.

PubMed  PubMed Central  Google Scholar 

Khan S, Khan SA, Luo X, Fattah FJ, Saltarski J, Gloria-McCutchen Y, Lu R, Xie Y, Li Q, Wakeland E, Gerber DE. Immune dysregulation in cancer patients developing immune-related adverse events. Br J Cancer. 2019;120(1):63–8.

CAS  PubMed  Google Scholar 

Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009;139(11):2079–86.

CAS  PubMed  Google Scholar 

Klemmt PAB, Carver JG, Kennedy SH, Koninckx PR, Mardon HJ. Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity. Fertil Steril. 2006;85:564–72.

CAS  PubMed  PubMed Central  Google Scholar 

Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA. 1998;95(26):15677–82.

CAS  PubMed  PubMed Central  Google Scholar 

Lahlou M. Screening of natural products for drug discovery. Expert Opin Drug Discov. 2007;2(5):697–705.

CAS  PubMed  Google Scholar 

Le Tutour B, Guedon D. Antioxidative activities of Olea europaea leaves and related phenolic compounds. Phytochemistry. 1992;31(4):1173–8.

Google Scholar 

Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril. 2001;75(1):1–10.

CAS  PubMed  Google Scholar 

Lin Y-H, Chen Y-H, Chang H-Y, Au H-K, Tzeng C-R, Huang Y-H. Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies. Int J Mol Sci. 2018;19(8):2385.

PubMed  PubMed Central  Google Scholar