Pathology - Research Article
Botega A.A.R.a· Amorim C.V.a· Teixeira F.a· Borges Figueira de Mello C.D.b· Stelini R.F.a· Velho P.E.N.F.b· Cintra M.L.aaDepartment of Pathology, School of Medical Sciences, State University of Campinas, Campinas, Brazil
bDepartment of Dermatology, School of Medical Sciences, State University of Campinas, Campinas, Brazil
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Article / Publication DetailsFirst-Page Preview
Received: May 01, 2022
Accepted: July 04, 2022
Published online: November 25, 2022
Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3
ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)
For additional information: https://www.karger.com/SAD
AbstractIntroduction: Distinguishing scarring (SA) versus non-scarring alopecia (NSA) may not be a simple procedure on either clinical or histopathological views. Aims: We sought to study the interobserver variability in the histopathological assessment of SA versus NSA, including clinical-pathological considerations. Methods: Two dermatopathologists independently interpreted the same set of 100 specimens (89 patients). The samples were serial sectioned and stained by hematoxylin and eosin and Verhöeff methods. The patients’ mean age was 46 years, with 13 being males and 76 females. Results: In 16/100 samples, there was no consensus among the two examiners regarding SA versus NSA (weighted kappa = 0.6583; 95% CI); 3/16 patients were re-biopsied, and in the second sample, consensus was reached. In 76/89 patients, the anatomopathological examination was helpful in defining the SA versus NSA subtype. Of the 84 samples in which there was interobserver agreement, 4 which had been considered scarring in the routine pathological report were re-classified as non-scarring, whereas one biopsy, previously diagnosed as non-scarring, was now considered cicatricial due to the newly found areas of lichenoid inflammation in the infundibular epithelium. Discussion: The ideal scalp examination may require deep serial biopsy sectioning, elastic tissue stain, re-biopsy, and strict clinical-evolutive correlation.
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References Griggs J, Trüeb RM, Gavazzoni Dias MFR, Hordinsky M, Tosti A. Fibrosing alopecia in a pattern distribution. J Am Acad Dermatol. 2021;85(6):1557–64. Wu WY, Otberg N, McElwee KJ, Shapiro J. Diagnosis and management of primary cicatricial alopecia: Part II. Skinmed. 2008;7(2):78–83. Sperling LC. Scarring alopecia and the dermatopathologist. J Cutan Pathol. 2001;28(7):333–42. Tan T, Guitart J, Gerami P, Yazdan P. Elastic staining in differentiating between follicular streamers and follicular scars in horizontal scalp biopsy sections. Am J Dermatopathol. 2018;40(4):254–8. Pinkus H. Differential patterns of elastic fibers in scarring and non-scarring alopecias. J Cutan Pathol. 1978;5(3):93–104. Fung MA, Sharon VR, Ratnarathorn M, Konia TH, Barr KL, Mirmirani P. Elastin staining patterns in primary cicatricial alopecia. J Am Acad Dermatol. 2013;69(5):776–82. Ross EK, Tan E, Shapiro J. Update on primary cicatricial alopecias. J Am Acad Dermatol. 2005;53:1–37. Bolduc C, Sperling LC, Shapiro J. Primary cicatricial alopecia: lymphocytic primary cicatricial alopecias, including chronic cutaneous lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, and Graham-Little syndrome. J Am Acad Dermatol. 2016;75(6):1081–99. Miteva M, Romanelli P, Tosti A. Pigmented casts. Am J Dermatopathol. 2014;36(1):58–63. Du X, Li Z, Xu W, Zhou X, Tang S, Song C, et al. Diagnostic value of horizontal versus vertical sections for scarring and non-scarring alopecia: a systematic review and meta-analysis. Eur J Dermatol. 2016;26(4):361–9. Mehregan AH, Mehregan DA. Syringoma-like sweat duct proliferation in scalp alopecias. J Cutan Pathol. 1990;17(6):355–7. Chung HJ, Goldberg LJ. Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: emphasis on follicular findings. J Am Acad Dermatol. 2017;77(2):349–55. Doytcheva K, Tan T, Guitart J, Gerami P, Yazdan P. Naked hair shafts as a marker of cicatricial alopecia. Am J Dermatopathol. 2018;40(7):498–501. Pierard-Franchimont C, Pierard GE. Corroborative evidence that alopecia areata involves the epidermis and the sebaceous glands. Am J Dermatopathol. 1987;9(2):111–3. Rittié L, Tejasvi T, Harms PW, Xing X, Nair RP, Gudjonsson JE, et al. Sebaceous gland atrophy in psoriasis: an explanation for psoriatic alopecia? J Invest Dermatol. 2016;136(9):1792–800. Harries MJ, Trueb RM, Tosti A, Messenger AG, Chaudhry I, Whiting DA, et al. How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. Br J Dermatol. 2009;160(3):482–501. Kolivras A, Thompson C. Primary scalp alopecia: new histopathological tools, new concepts and a practical guide to diagnosis. J Cutan Pathol. 2017;44(1):53–69. Zembowicz A, Ahmad A, Lyle SR. A comprehensive analysis of a web-based dermatopathology second opinion consultation practice. Arch Pathol Lab Med. 2011;135(3):379–83. Wohltmann WE, Sperling L. Histopathologic diagnosis of multifactorial alopecia. J Cutan Pathol. 2016;43(6):483–91. Fukuyama M, Ohyama M. Use of trichoscopy for the diagnosis of alopecia areata coexisting with primary scarring alopecia in a female hair loss patient. J Dermatol. 2019;46(5):418–21. McElwee KJ. Etiology of cicatricial alopecias : a basic science point of view. Dermatol Ther. 2008;21(4):212–20. Article / Publication DetailsFirst-Page Preview
Received: May 01, 2022
Accepted: July 04, 2022
Published online: November 25, 2022
Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3
ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)
For additional information: https://www.karger.com/SAD
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