Clinical Neurology: Research Article

Kumar S.a· Raina J.K.c· Sudershan A.b,d· Mahajan K.b· Jasrotia R.a· Maharana C.a· Panjalia R.K.a· Kumar P.a,b

Author affiliations

aDepartment of Zoology, University of Jammu, Jammu, India
bInstitute of Human Genetics, University of Jammu, Jammu, India
cDepartment of Human Genetics, Govt. Gandhi Memorial Science College, Cluster University of Jammu, Jammu, India
dDepartment of Human Genetics, Sri Pratap College Srinagar, Cluster University of Srinagar, Kashmir, India

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Article / Publication Details

First-Page Preview

Received: May 27, 2022
Accepted: September 21, 2022
Published online: November 25, 2022

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 6

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Introduction: Migraine is a neurovascular disorder and is clinically characterized by episodic attacks of mild to severe headaches. Due to the involvement of multiple environmental and genetic factors, it has become a much more complex neurological condition to understand. Apart from the environmental variables, a plethora of genes have been implicated, and one such example is ESR1. The present study was focused to find out the association of two important polymorphisms, namely, PvuII and XbaI of the ESR1 with migraine in the population of Jammu and Kashmir (UT). Methods: The PCR-RFLP genotyping method was utilized to detect PvuII and XbaI polymorphism, and the result was confirmed by statistical analysis. Results: Although we did not find a signification association of ESR-PvuII polymorphism with migraine susceptibility , a strong association was found with the clinical subtype of migraine; migraine with aura (MA) . Furthermore, a significant association of ESR-XbaI polymorphism was observed with migraine and MA . Conclusion: In conclusion, ESR1-XbaI polymorphism is significantly associated with migraine risk including both subtypes (MA and MO) in the North Indian population of Jammu.

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First-Page Preview

Received: May 27, 2022
Accepted: September 21, 2022
Published online: November 25, 2022

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 6

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

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