Mayer, S., Metzger, R. & Kluth, D. The embryology of the diaphragm. Semin. Pediatr. Surg. 20, 161–169 (2011).
Deprest, J. A. et al. Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe. Clin. Perinatol. 36, 329–347 (2009).
Hagadorn, J. I. et al. Trends in treatment and in-hospital mortality for neonates with congenital diaphragmatic hernia. J. Perinatol. 35, 748–754 (2015).
Article CAS PubMed Google Scholar
Gien, J. & Kinsella, J. P. Management of pulmonary hypertension in infants with congenital diaphragmatic hernia. J. Perinatol. 36, S28–S31 (2016).
Deprest, J. A. et al. Randomized trial of fetal surgery for severe left diaphragmatic hernia. N. Engl. J. Med. 385, 107–118 (2021).
Article PubMed PubMed Central Google Scholar
Kashyap, A. et al. Antenatal medical therapies to improve lung development in congenital diaphragmatic hernia. Am. J. Perinatol. 35, 823–836 (2018).
Kitagawa, M., Hislop, A., Boyden, E. A. & Reid, L. Lung hypoplasia in congenital diaphragmatic hernia a quantitative study of airway, artery, and alveolar development. Br. J. Surg. 58, 342–346 (1971).
Article CAS PubMed Google Scholar
Shinkai, M., Shinkai, T., Montedonico, S. & Puri, P. Effect of VEGF on the branching morphogenesis of normal and nitrofen-induced hypoplastic fetal rat lung explants. J. Pediatr. Surg. 41, 781–786 (2006).
Oue, T., Shima, H., Taira, Y. & Puri, P. Administration of antenatal glucocorticoids upregulates peptide growth factor gene expression in nitrofen-induced congenital diaphragmatic hernia in rats. J. Pediatr. Surg. 35, 109–112 (2000).
Article CAS PubMed Google Scholar
Keller, R. L. et al. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am. J. Respir. Crit. Care Med. 182, 555–561 (2010).
Article CAS PubMed PubMed Central Google Scholar
Sood, B. G., Wykes, S., Landa, M., De Jesus, L. & Rabah, R. Expression of eNOS in the lungs of neonates with pulmonary hypertension. Exp. Mol. Pathol. 90, 9–12 (2011).
Article CAS PubMed Google Scholar
Cabral, J. E. B. & Belik, J. Persistent pulmonary hypertension of the newborn: recent advances in pathophysiology and treatment. J. Pediatr. (Rio. J.). 89, 226–242 (2013).
Lemus-Varela, M. et al. Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphragmatic hernia. World J. Pediatr. 10, 354–359 (2014).
Article CAS PubMed Google Scholar
Kattan, J., Céspedes, C., González, A. & Vio, C. P. Sildenafil stimulates and dexamethasone inhibits pulmonary vascular development in congenital diaphragmatic hernia rat lungs. Neonatology 106, 74–80 (2014).
Article CAS PubMed Google Scholar
Burgos, C. M. et al. Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr. Res. 80, 577–585 (2016).
Article CAS PubMed Google Scholar
Durante, W. Role of arginase in vessel wall remodeling. Front. Immunol. 4, 111 (2013).
Article PubMed PubMed Central Google Scholar
Yang, Z. & Ming, X.-F. Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation. Front. Immunol. 4, 149 (2013).
Article PubMed PubMed Central Google Scholar
Belik, J., Shehnaz, D., Pan, J. & Grasemann, H. Developmental changes in arginase expression and activity in the lung. Am. J. Physiol. Lung Cell Mol. Physiol. 294, 498–504 (2008).
Krause, B. J. et al. Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia. J. Hypertens. 33, 515–524 (2015).
Article CAS PubMed Google Scholar
Chen, B., Calvert, A. E., Cui, H. & Nelin, L. D. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase. Blood Cells Mol. Dis. 31, 1151–1159 (2003).
XU, W. et al. Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J. 18, 1746–1748 (2004).
Article CAS PubMed Google Scholar
Manson, J. M. Mechanism of nitrofen teratogenesis. Environ. Health Perspect. 70, 137–147 (1986).
Article CAS PubMed PubMed Central Google Scholar
Krause, B. J. et al. Chronic intermittent hypoxia-induced vascular dysfunction in rats is reverted by N-acetylcysteine supplementation and arginase inhibition. Front. Physiol. 9, 901 (2018).
Article PubMed PubMed Central Google Scholar
Grasemann, H. et al. Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 308, L503–L510 (2015).
Article CAS PubMed Google Scholar
Kim, J. H. et al. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J. Appl. Physiol. 107, 1249–1257 (2009).
Article CAS PubMed PubMed Central Google Scholar
Mehl, A. et al. Effect of arginase inhibition on pulmonary L-arginine metabolism in murine pseudomonas pneumonia. PLoS One 9, e90232 (2014).
Article PubMed PubMed Central Google Scholar
Xu, L. et al. Arginase and autoimmune inflammation in the central nervous system. Immunology 110, 141–148 (2003).
Article CAS PubMed PubMed Central Google Scholar
Corraliza, I. M., Campo, M. L., Soler, G. & Modolell, M. Determination of arginase activity in macrophages: a micromethod. J. Immunol. Methods 174, 231–235 (1994).
Article CAS PubMed Google Scholar
Marulanda, K., Tsihlis, N. D., McLean, S. E. & Kibbe, M. R. Emerging antenatal therapies for congenital diaphragmatic hernia-induced pulmonary hypertension in preclinical models. Pediatr. Res. 89, 1641–1649 (2021).
Luong, C. et al. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 123, 2120–2131 (2011).
Article CAS PubMed Google Scholar
Mous, D. S. et al. Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag’s active compound, at the pseudoglandular stage improves lung vasculature. Am. J. Physiol. Lung Cell. Mol. Physiol. 315, L276–L285 (2018).
Article CAS PubMed Google Scholar
Yamamoto, Y. et al. Doppler parameters of fetal lung hypoplasia and impact of sildenafil. Am. J. Obstet. Gynecol. 211, 263.e1–8 (2014).
Article CAS PubMed Google Scholar
Russo, F. M. et al. Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia. Thorax 71, 517–525 (2016).
Rabelo, L. A., Ferreira, F. O., Nunes-Souza, V., da Fonseca, L. J. S. & Goulart, M. O. F. Arginase as a critical prooxidant mediator in the binomial endothelial dysfunction-atherosclerosis. Oxid. Med. Cell. Longev. 2015, 924860 (2015).
Article PubMed PubMed Central Google Scholar
Durante, W., Johnson, F. K. & Johnson, R. A. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin. Exp. Pharmacol. Physiol. 34, 906–911 (2007).
Article CAS PubMed PubMed Central Google Scholar
Sasaki, A., Doi, S., Mizutani, S. & Azuma, H. Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L1480–L1487 (2007).
Article CAS PubMed Google Scholar
Pernow, J. & Jung, C. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Cardiovasc. Res. 98, 334–343 (2013).
Article CAS PubMed Google Scholar
Hochstedler, C. M., Leidinger, M. R., Maher-Sturm, M. T., Gibson-Corley, K. N. & Meyerholz, D. K. Immunohistochemical detection of arginase-I expression in formalin-fixed lung and other tissues. J. Histotechnol. 36, 128–134 (2013).
留言 (0)