Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127:3029–30. https://doi.org/10.1002/cncr.33587.

Article  PubMed  Google Scholar 

Cheng X, et al. Systematic pan-cancer analysis of KLRB1 with prognostic value and immunological activity across human tumors. J Immunol Res. 2022;2022:5254911. https://doi.org/10.1155/2022/5254911.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grech G, et al. EPMA position paper in cancer: current overview and future perspectives. EPMA J. 2015;6:9. https://doi.org/10.1186/s13167-015-0030-6.

Article  PubMed  PubMed Central  Google Scholar 

Hamid O, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013;369:134–44. https://doi.org/10.1056/NEJMoa1305133.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doebele RC, et al. An oncogenic NTRK fusion in a patient with soft-tissue sarcoma with response to the tropomyosin-related kinase inhibitor LOXO-101. Cancer Discov. 2015;5:1049–57. https://doi.org/10.1158/2159-8290.Cd-15-0443.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen F, et al. Pan-cancer analysis of the prognostic and immunological role of HSF1: a potential target for survival and immunotherapy. Oxid Med Cell Longev. 2021;2021:5551036. https://doi.org/10.1155/2021/5551036.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou X, et al. A pan-cancer analysis of CD161, a potential new immune checkpoint. Front Immunol. 2021;12:688215. https://doi.org/10.3389/fimmu.2021.688215.

Weinstein JN, et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013;45:1113–20. https://doi.org/10.1038/ng.2764.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bodrova TA, et al. Introduction into PPPM as a new paradigm of public health service: an integrative view. EPMA J. 2012;3:16. https://doi.org/10.1186/1878-5085-3-16.

Article  PubMed  PubMed Central  Google Scholar 

Malbec L, et al. Dynamic methylome of internal mRNA N(7)-methylguanosine and its regulatory role in translation. Cell Res. 2019;29:927–41. https://doi.org/10.1038/s41422-019-0230-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin S, et al. Mettl1/Wdr4-mediated m(7)G tRNA methylome is required for normal mRNA translation and embryonic stem cell self-renewal and differentiation. Mol Cell. 2018;71:244-255.e245. https://doi.org/10.1016/j.molcel.2018.06.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Zhang Y, Chi Q, Wang Z, Sun B. Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis. Life Sci. 2020;249:117480. https://doi.org/10.1016/j.lfs.2020.117480.

Qin MM, et al. let-7i inhibits proliferation and migration of bladder cancer cells by targeting HMGA1. BMC Urol. 2019;19:53. https://doi.org/10.1186/s12894-019-0485-1.

Article  PubMed  PubMed Central  Google Scholar 

Elghoroury EA, et al. Evaluation of miRNA-21 and miRNA Let-7 as prognostic markers in patients with breast cancer. Clin Breast Cancer. 2018;18:e721–6. https://doi.org/10.1016/j.clbc.2017.11.022.

Article  CAS  PubMed  Google Scholar 

Ma L, Zhao Q, Chen W, Zhang Y. Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner. Oncol Lett. 2018;15:6975–81. https://doi.org/10.3892/ol.2018.8250.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, et al. METTL1 promotes neuroblastoma development through m(7)G tRNA modification and selective oncogenic gene translation. Biomarker research. 2022;10:68. https://doi.org/10.1186/s40364-022-00414-z.

Article  PubMed  PubMed Central  Google Scholar 

Wang C, et al. Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway. Oncol Lett. 2021;21:330. https://doi.org/10.3892/ol.2021.12591.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang T, et al. Comprehensive analysis of nine m7G-related lncRNAs as prognosis factors in tumor immune microenvironment of hepatocellular carcinoma and experimental validation. Front Genet. 2022;13: 929035. https://doi.org/10.3389/fgene.2022.929035.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, et al. m7G regulator-mediated molecular subtypes and tumor microenvironment in kidney renal clear cell carcinoma. Front Pharmacol. 2022;13: 900006. https://doi.org/10.3389/fphar.2022.900006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su C, et al. Single-cell RNA sequencing in multiple pathologic types of renal cell carcinoma revealed novel potential tumor-specific markers. Front Oncol. 2021;11:719564. https://doi.org/10.3389/fonc.2021.719564.

Human genomics. The genotype-tissue expression (GTEx) pilot analysis. Science (New York, NY). 2015;348:648–60. https://doi.org/10.1126/science.1262110.

Article  CAS  Google Scholar 

Linehan WM, Ricketts CJ. The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implications. Nat Rev Urol. 2019;16:539–52. https://doi.org/10.1038/s41585-019-0211-5.

Article  CAS  PubMed  Google Scholar 

Blum A, Wang P, Zenklusen J. C. SnapShot: TCGA-analyzed tumors. Cell. 2018;173:530. https://doi.org/10.1016/j.cell.2018.03.059.

Article  CAS  PubMed  Google Scholar 

Yang W, et al. Genomics of drug sensitivity in cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013;41:D955-961. https://doi.org/10.1093/nar/gks1111.

Article  CAS  PubMed  Google Scholar 

Fu Y, et al. Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis. Nature cancer. 2020;1:800–10. https://doi.org/10.1038/s43018-020-0085-8.

Article  CAS  PubMed  Google Scholar 

Carpenter AE, et al. Cell Profiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 2006;7:R100. https://doi.org/10.1186/gb-2006-7-10-r100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizvi AA, et al. gwasurvivr: an R package for genome-wide survival analysis. Bioinformatics (Oxford, England). 2019;35:1968–70. https://doi.org/10.1093/bioinformatics/bty920.

Article  CAS  PubMed  Google Scholar 

van Dyk E, Reinders MJ, Wessels LF. A scale-space method for detecting recurrent DNA copy number changes with analytical false discovery rate control. Nucleic Acids Res. 2013;41:e100. https://doi.org/10.1093/nar/gkt155.

Liu CJ, et al. GSCALite: a web server for gene set cancer analysis. Bioinformatics (Oxford, England). 2018;34:3771–2. https://doi.org/10.1093/bioinformatics/bty411.

Article  CAS  PubMed  Google Scholar 

Zhuang W, et al. An immunogenomic signature for molecular classification in hepatocellular carcinoma. Molecular therapy Nucleic acids. 2021;25:105–15. https://doi.org/10.1016/j.omtn.2021.06.024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, et al. m7G-Associated subtypes, tumor microenvironment, and validation of prognostic signature in lung adenocarcinoma. Front Genet. 2022;13: 954840. https://doi.org/10.3389/fgene.2022.954840.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao B, et al. Identification and verification of immune-related gene prognostic signature based on ssGSEA for osteosarcoma. Front Oncol. 2020;10: 607622. https://doi.org/10.3389/fonc.2020.607622.

Article  PubMed  PubMed Central  Google Scholar 

Sherif S, et al. The immune landscape of solid pediatric tumors. J Exp Clin Cancer Res: CR. 2022;41:199. https://doi.org/10.1186/s13046-022-02397-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Misund K, et al. Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence. Leukemia. 2022;36:1887–97. https://doi.org/10.1038/s41375-022-01597-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li T, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Can Res. 2017;77:e108–10. https://doi.org/10.1158/0008-5472.Can-17-0307.

Article  CAS  Google Scholar 

Tang Z, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98-w102. https://doi.org/10.1093/nar/gkx247.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan H, et al. CancerSEA: a cancer single-cell state atlas. Nucleic Acids Res. 2019;47:D900-d908. https://doi.org/10.1093/nar/gky939.

Article  CAS  PubMed  Google Scholar 

Patel SS, Lovko VJ, Lockey RF. Red Tide: overview and clinical manifestations. J Allergy Clin Immunol In practice. 2020;8:1219–23. https://doi.org/10.1016/j.jaip.2019.10.030.

Article  Google Scholar