Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders

Parshukova D, Smirnova LP, Ermakov EA, Bokhan NA, Semke AV, Ivanova SA, et al. Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein. J Mol Recogn. 2019;32:e2759.

Article  Google Scholar 

Benedetti F, Aggio V, Pratesi ML, Greco G, Furlan R. Neuroinflammation in Bipolar Depression. Front Psychiatry. 2020;11:71.

Article  PubMed  PubMed Central  Google Scholar 

Resende R, Fernandes T, Pereira AC, De Pascale J, Marques AP, Oliveira P, et al. Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role? Biochim Biophys Acta Mol Basis Dis. 2020;1866:165752.

Article  CAS  PubMed  Google Scholar 

Meltzer A, Van de Water J. The Role of the Immune System in Autism Spectrum Disorder. Neuropsychopharmacology. 2017;42:284–98.

Article  CAS  PubMed  Google Scholar 

Webers A, Heneka MT, Gleeson PA. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer’s disease. Immunol Cell Biol. 2020;98:28–41.

Article  PubMed  Google Scholar 

De Virgilio A, Greco A, Fabbrini G, Inghilleri M, Rizzo MI, Gallo A, et al. Parkinson’s disease: Autoimmunity and neuroinflammation. Autoimmun Rev. 2016;15:1005–11.

Article  PubMed  Google Scholar 

Lu Y, Li K, Hu Y, Wang X. Expression of Immune Related Genes and Possible Regulatory Mechanisms in Alzheimer’s Disease. Front Immunol. 2021;12:768966.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Shao Z, Xu S, Liu Q, Liu C, Luo Y, et al. Immune Profiling of Parkinson’s Disease Revealed Its Association With a Subset of Infiltrating Cells and Signature Genes. Front Aging Neurosci. 2021;13:605970.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horiuchi F, Yoshino Y, Kumon H, Hosokawa R, Nakachi K, Kawabe K, et al. Identification of aberrant innate and adaptive immunity based on changes in global gene expression in the blood of adults with autism spectrum disorder. J Neuroinflammation. 2021;18:102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fillman SG, Sinclair D, Fung SJ, Webster MJ, Shannon, Weickert C. Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Transl Psychiatry. 2014;4:e365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saetre P, Emilsson L, Axelsson E, Kreuger J, Lindholm E, Jazin E. Inflammation-related genes up-regulated in schizophrenia brains. BMC Psychiatry. 2007;7:46.

Article  PubMed  PubMed Central  Google Scholar 

Cai HQ, Catts VS, Webster MJ, Galletly C, Liu D, O’Donnell M, et al. Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation. Mol Psychiatry. 2020;25:761–75.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Catts VS, Sheedy D, McCrossin T, Kril JJ, Shannon Weickert C. Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammation. Transl Psychiatry. 2016;6:e982.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volk DW. Role of microglia disturbances and immune-related marker abnormalities in cortical circuitry dysfunction in schizophrenia. Neurobiol Dis. 2017;99:58–65.

Article  CAS  PubMed  Google Scholar 

Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science. 2018;359:693–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018;362:6420–15.

Yuan N, Chen Y, Xia Y, Dai J, Liu C. Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Transl Psychiatry. 2019;9:233–13.

Hart BAT, den Dunnen WF. Commentary on special issue: CNS diseases and the immune system. J Neuroimmune Pharm. 2013;8:757–9.

Article  Google Scholar 

Gendelman HE. Neural immunity: Friend or foe? J Neurovirol. 2002;8:474–9.

Article  CAS  PubMed  Google Scholar 

Mitra S, Chakrabarti N, Dutta SS, Ray S, Bhattacharya P, Sinha P, et al. Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson’s disease. Neuroscience. 2015;292:46–70.

Article  CAS  PubMed  Google Scholar 

Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation. 2008;15:323–30.

Article  CAS  PubMed  Google Scholar 

Owens T, Wekerle H, Antel J. Genetic models for CNS inflammation. Nat Med. 2001;7:161–6.

Article  CAS  PubMed  Google Scholar 

Dantzer R. Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa. Physiol Rev. 2018;98:477–504.

Article  CAS  PubMed  Google Scholar 

Nasr IW, Chun Y, Kannan S. Neuroimmune responses in the developing brain following traumatic brain injury. Exp Neurol. 2019;320:112957.

Article  CAS  PubMed  Google Scholar 

D’Mello C, Swain MG. Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression. Curr Top Behav Neurosci. 2017;31:73–94.

Article  PubMed  Google Scholar 

Kelley KW, Bluthe RM, Dantzer R, Zhou JH, Shen WH, Johnson RW. et al. Cytokine-induced sickness behavior. Brain Behav Immun. 2003;17 Suppl 1:S112–8.

Article  CAS  PubMed  Google Scholar 

Lyman M, Lloyd DG, Ji X, Vizcaychipi MP, Ma D. Neuroinflammation: the role and consequences. Neurosci Res. 2014;79:1–12.

Article  CAS  PubMed  Google Scholar 

Ozawa K, Hashimoto K, Kishimoto T, Shimizu E, Ishikura H, Iyo M. Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry. 2006;59:546–54.

Article  CAS  PubMed  Google Scholar 

Vuillermot S, Weber L, Feldon J, Meyer U. A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia. J Neurosci. 2010;30:1270–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lammert CR, Lukens JR. Modeling Autism-Related Disorders in Mice with Maternal Immune Activation (MIA). Methods Mol Biol. 2019;1960:227–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volk DW, Chitrapu A, Edelson JR, Roman KM, Moroco AE, Lewis DA. Molecular mechanisms and timing of cortical immune activation in schizophrenia. Am J Psychiatry 2015;172:1112–21.

Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, et al. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation. 2008;5:37.

Article  PubMed  PubMed Central  Google Scholar 

Purves-Tyson TD, Robinson K, Brown AM, Boerrigter D, Cai HQ, Weissleder C, et al. Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia. Front Immunol. 2020;11:2002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. 2012;4:147ra111.

Article  PubMed  PubMed Central  Google Scholar 

Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morey JN, Boggero IA, Scott AB, Segerstrom SC. Current Directions in Stress and Human Immune Function. Curr Opin Psychol. 2015;5:13–7.

Article  PubMed  PubMed Central  Google Scholar 

Kim SY, Buckwalter M, Soreq H, Vezzani A, Kaufer D. Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia. 2012;53 Suppl 6:37–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukherjee S. Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Heliyon. 2021;7:e08518.

Article  CAS  PubMed  PubMed Central 

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