Safety and Potential Efficacy of Escalating Dose of Ustekinumab in Pediatric Crohn Disease (the Speed-up Study): A Multicenter Study from the Pediatric IBD Porto Group of ESPGHAN

From the *Pediatric Gastroenterology Institute, “Dana-Dwek” Children’s Hospital, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

the †Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain

the ‡Department of Paediatric Gastroenterology, Children’s Hospital and University of Helsinki, Helsinki, Finland and Tampere University, Tampere, Finland

the §Pediatric Gastroenterology Unit, PIBD Research Center, Wolfson Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

the ‖Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway

the ¶Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, Israel

the #Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

the **Gastroenterology, Digestive Endoscopy and Nutrition Unit, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Trieste, Italy

the ††Department of Clinical Science and Education, Karolinska Institute, and Department of Gastroenterology, Sachs’ Children and Youth Hospital, Stockholm, Sweden

the ‡‡Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska University Hospital, Stockholm, Sweden

the §§Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic

the ‖‖Gastroenterology and Nutrition Unit, Meyer Children’s Hospital, Florence, Italy

the ¶¶Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

the ##Pediatric Gastroenterology and Nutrition Institute, Ruth Children’s Hospital of Haifa, Rambam Medical Center, Faculty of Medicine, The Technion, Haifa, Israel

the ***Paediatric Gastroenterology Unit, Ha’Emek Medical Centre, Afula, Faculty of Medicine, The Technion, Haifa, Israel

the †††The Jecheskiel Sigi Gonczarowski Pediatric Gastroenterology Unit, Shamir Medical Center, Zerifin, Israel

‡‡‡The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel

the §§§Department of Pediatric Gastroenterology, Amsterdam University Medical Centre, Amsterdam, the Netherlands

the ‖‖‖Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Umberto I Hospital, Sapienza University of Rome, Rome, Italy

the ¶¶¶Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Niño Jesús, Madrid, Spain

the ###Pediatric Gastroenterology Unit, Department of Pediatrics, Maggiore Hospital, Bologna, Italy

the ****Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria

the ††††Paediatric Gastroenterology, University Medical Centre Groningen Beatrix Childrens Hospital, Groningen, the Netherlands

the ‡‡‡‡Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, Málaga, Spain

the §§§§Department of Pediatric Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, United Kingdom

the ‖‖‖‖Department of Paediatrics, Hospital Universitario de Fuenlabrada, Madrid, Spain

the ¶¶¶¶The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, and the Hebrew University of Jerusalem, Jerusalem, Israel.

Received June 2, 2022; accepted July 31, 2022.

GPM has received speakers fees and congress support from Abbvie, Nestlé Health Science, Janssen and Nutricia. KLK has received consultancy fees from Abbvie, Biocodex, Ferring and Tillotts Pharma and funding for research from Pediatric Research Foundation and Helsinki University Hospital Research Fund. OH reports lectures/congress fees/consultancy (outside the submitted work): MSD, AbbVie, Takeda, Nutricia, Nestlé and Ferring. OH reports lectures/congress fees/consultancy (outside the submitted work): MSD, AbbVie, Takeda, Nutricia, Nestlé and Ferring. The remaining authors report no conflicts of interest.

Although this paper is produced by the ESPGHAN PORTO IBDWG it does not necessarily represent ESPGHAN policy and is not endorsed by ESPGHAN.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.jpgn.org).

The data underlying this article will be shared on reasonable request to the corresponding author.

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