Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, Li P, Zhou Y, Lin YF, Duan Q, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. J Infect. 2020;80(6):656–65.

Article  PubMed  PubMed Central  Google Scholar 

Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, Kim BT, Kim SJ. Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel Coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol. 2020;30(3):313–24.

Article  PubMed  Google Scholar 

Schmalz G, Jakubovics N, Schwendicke F. Normative approaches for oral health: standards, specifications, and guidelines. J Dent Res. 2022;101(5):489–94.

Article  PubMed  Google Scholar 

Bhat RA, Maqbool S, Rathi A, Ali SM, Hussenbocus Y, Wentao X, Qu Y, Zhang Y, Sun Y, Fu HX, et al. The effects of the SARS-CoV-2 virus on the cardiovascular system and coagulation state leading to cardiovascular diseases: a narrative review. Inquiry. 2022;59:469580221093442.

PubMed  Google Scholar 

Costa CA, Vilela ACS, Oliveira SA, Gomes TD, Andrade AAC, Leles CR, Costa NL. Poor oral health status and adverse COVID-19 outcomes: a preliminary study in hospitalized patients. J Periodontol. 2022. https://doi.org/10.1002/JPER.21-0624.

Article  PubMed  PubMed Central  Google Scholar 

Patel J, Woolley J. Necrotizing periodontal disease: oral manifestation of COVID-19. Oral Dis. 2021;27(Suppl 3):768–9.

Article  PubMed  Google Scholar 

Anand PS, Jadhav P, Kamath KP, Kumar SR, Vijayalaxmi S, Anil S. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J Periodontol. 2022;93(4):584–90.

Article  PubMed  Google Scholar 

Nijakowski K, Wyzga S, Singh N, Podgorski F, Surdacka A. Oral manifestations in SARS-CoV-2 positive patients: a systematic review. J Clin Med. 2022;11(8):2202.

Article  PubMed  PubMed Central  Google Scholar 

Boyapati R, Dhulipalla R, Kolaparthy LK, Bodduru R. COVID-19 and oral implications: an updated review. J Oral Maxillofac Pathol. 2021;25(3):400–3.

Article  PubMed  Google Scholar 

Zhang D, Liu W, Peng L, Wang H, Lin M, Li Y, Wang Z. Difference in oral microbial composition between chronic periodontitis patients with and without diabetic nephropathy. BMC Oral Health. 2022;22(1):12.

Article  PubMed  PubMed Central  Google Scholar 

Hwang SY, Oh H, Rhee MY, Kang S, Kim HY. Association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension in middle-aged and older adults in Korea: A 10-year follow-up study. J Periodontol. 2022. https://doi.org/10.1002/JPER.21-0706.

Article  PubMed  Google Scholar 

Eke PI, Borgnakke WS, Genco RJ. Recent epidemiologic trends in periodontitis in the USA. Periodontol. 2020;82(1):257–67. https://doi.org/10.1111/prd.12323.

Article  Google Scholar 

Zhan J, Zhang Y, Wang X, Tai B, Hu D, Lin H, Wang B, Si Y, Wang C, Zheng S, et al. Related factors of periodontal health among Chinese middle school students, findings from a national cross-sectional survey. BMC Oral Health. 2021;21(1):517.

Article  PubMed  PubMed Central  Google Scholar 

Van Dyke TE, Sima C. Understanding resolution of inflammation in periodontal diseases: is chronic inflammatory periodontitis a failure to resolve? Periodontol. 2020;82(1):205–13.

Article  Google Scholar 

Febbraio M, Roy CB, Levin L. Is there a causal link between periodontitis and cardiovascular disease? A concise review of recent findings. Int Dent J. 2022;72(1):37–51.

Article  PubMed  Google Scholar 

Berglundh T, Donati M. Aspects of adaptive host response in periodontitis. J Clin Periodontol. 2005;32(Suppl 6):87–107.

Article  PubMed  Google Scholar 

Gomez-Costa D, Ramirez JM, Garcia Guerrero I, Giovannini G, Rojo R, Gomez-de Diego R. A retrospective study on the effect of the COVID-19 pandemic on dental treatments in adults. BMC Oral Health. 2022;22(1):122.

Article  PubMed  PubMed Central  Google Scholar 

Jin SH, Zhou RH, Guan XY, Zhou JG, Liu JG. Identification of novel key lncRNAs involved in periodontitis by weighted gene co-expression network analysis. J Periodontal Res. 2020;55(1):96–106.

Article  PubMed  Google Scholar 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.

Article  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Furumichi M, Sato Y, Ishiguro-Watanabe M, Tanabe M. KEGG: integrating viruses and cellular organisms. Nucleic Acids Res. 2021;49(D1):D545–51.

Article  PubMed  Google Scholar 

Chen Y, Wang X. miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res. 2020;48(D1):D127–31.

Article  PubMed  Google Scholar 

Huang HY, Lin YC, Li J, Huang KY, Shrestha S, Hong HC, Tang Y, Chen YG, Jin CN, Yu Y, et al. miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database. Nucleic Acids Res. 2020;48(D1):D148–54.

PubMed  Google Scholar 

McGeary SE, Lin KS, Shi CY, Pham TM, Bisaria N, Kelley GM, Bartel DP. The biochemical basis of microRNA targeting efficacy. Science. 2019. https://doi.org/10.1126/science.aav1741.

Article  PubMed  PubMed Central  Google Scholar 

Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, Hackl H, Trajanoski Z. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. 2017;18(1):248–62.

Article  PubMed  Google Scholar 

Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis. Int Dent J. 2021;71(6):462–76.

Article  PubMed  PubMed Central  Google Scholar 

Melo P, Barbosa JM, Jardim L, Carrilho E, Portugal J. COVID-19 management in clinical dental care part I: epidemiology public health implications and risk assessment. Int Dent J. 2021;71(3):251–62.

Article  PubMed  PubMed Central  Google Scholar 

Aquino-Martinez R, Hernandez-Vigueras S. Severe COVID-19 lung infection in older people and periodontitis. J Clin Med. 2021;10(2):279.

Article  PubMed Central  Google Scholar 

Ohnishi T, Nakamura T, Shima K, Noguchi K, Chiba N, Matsuguchi T. Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). J Oral Biosci. 2022;64(2):229–36.

Article  PubMed  PubMed Central  Google Scholar 

Peng D, Gao Y, Zhang L, Liu Z, Wang H, Liu Y. The relationship between hepcidin-mediated iron dysmetabolism and COVID-19 severity: a meta-analysis. Front Public Health. 2022;10: 881412.

Article  PubMed  PubMed Central  Google Scholar 

Han Y, Huang W, Meng H, Zhan Y, Hou J. Pro-inflammatory cytokine interleukin-6-induced hepcidin, a key mediator of periodontitis-related anemia of inflammation. J Periodontal Res. 2021;56(4):690–701.

Article  PubMed  Google Scholar 

Osman IO, Garrec C, de Souza GAP, Zarubica A, Belhaouari DB, Baudoin JP, Lepidi H, Mege JL, Malissen B, Scola B, et al. Control of CDH1/E-cadherin gene expression and release of a soluble form of E-cadherin in SARS-CoV-2 infected caco-2 intestinal cells: physiopathological consequences for the intestinal forms of COVID-19. Front Cell Infect Microbiol. 2022;12: 798767.

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Zhang T, Zhang Z, Wang Z, Zhou YJ, Wang Z. B cell activating factor regulates periodontitis development by suppressing inflammatory responses in macrophages. BMC Oral Health. 2021;21(1):426.

Article  PubMed  PubMed Central  Google Scholar 

Li F, Fountzilas C, Puzanov I, Attwood KM, Morrison C, Ling X. Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5 a superior oncogenic biomarker and target for targeted cancer therapy. Am J Cancer Res. 2021;11(10):5190–213.

PubMed  PubMed Central  Google Scholar 

Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW. Adenylyl cyclase 5 regulation by gbetagamma involves isoform-specific use of multiple interaction sites. Mol Pharmacol. 2015;88(4):758–67.

Article  PubMed  PubMed Central  Google Scholar 

Zhou S, Zhang J, Xu J, Zhang F, Li P, He Y, Wu J, Wang C, Wang X, Zhang W, et al. An epigenome-wide DNA methylation study of patients with COVID-19. Ann Hum Genet. 2021;85(6):221–34.

Article  PubMed  PubMed Central  Google Scholar 

Matosin N, Newell KA, Quide Y, Andrews JL, Teroganova N, Green MJ, Fernandez F. Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia. Brain Imaging Behav. 2018;12(2):509–17.

Article  PubMed  Google Scholar 

Zeng Z, Lan T, Wei Y, Wei X. CCL5/CCR5 axis in human diseases and related treatments. Genes Dis. 2022;9(1):12–27.

Article  PubMed  Google Scholar 

Fageeh HN, Fageeh HI, Khan SS, Maganur PC, Vyas N, Patil VR, Raj AT, Baeshen HA, Patil S. Gingival crevicular fluid infiltrating CD14+ monocytes promote inflammation in periodontitis. Saudi J Biol Sci. 2021;28(5):3069–75.

Article  PubMed  PubMed Central  Google Scholar 

Guo X, Semerci N, De Assis V, Kayisli UA, Schatz F, Steffensen TS, Guzeloglu-Kayisli O, Lockwood CJ. Regulation of proinflammatory molecules and tissue factor by SARS-CoV-2 spike protein in human placental cells: implications for SARS-CoV-2