Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.

Article  PubMed  Google Scholar 

Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell. 2010;18:11–22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chung JH, Dewal N, Sokol E, Mathew P, Whitehead R, Millis SZ, et al. Prospective comprehensive genomic profiling of primary and metastatic prostate tumors. JCO Precis Oncol. 2019;3:PO.18.00283. https://doi.org/10.1200/PO.18.00283.

Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer. 2006;6:184–92.

Article  PubMed  CAS  Google Scholar 

Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Disco. 2009;8:627–44.

Article  CAS  Google Scholar 

Courtney KD, Corcoran RB, Engelman JA. The PI3K pathway as drug target in human cancer. J Clin Oncol. 2010;28:1075–83.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell. 2011;19:575–86.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 2008;26:1148–59.

Article  PubMed  Google Scholar 

Nakabayashi M, Werner L, Courtney KD, Buckle G, Oh WK, Bubley GJ, et al. Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer. BJU Int. 2012;110:1729–35.

Article  PubMed  CAS  Google Scholar 

Chow H, Ghosh PM, deVere White R, Evans CP, Dall’Era MA, Yap SA, et al. A phase 2 clinical trial of everolimus plus bicalutamide for castration-resistant prostate cancer. Cancer. 2016;122:1897–904.

Article  PubMed  CAS  Google Scholar 

George DJ, Halabi S, Healy P, Jonasch D, Anand M, Rasmussen J, et al. Phase 2 clinical trial of TORC1 inhibition with everolimus in men with metastatic castration-resistant prostate cancer. Urol Oncol. 2020;38:79.e15–22.

Article  CAS  Google Scholar 

Templeton AJ, Dutoit V, Cathomas R, Rothermundt C, Bartschi D, Droge C, et al. Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08). Eur Urol. 2013;64:150–8.

Article  PubMed  CAS  Google Scholar 

Singal G, Miller PG, Agarwala V, Li G, Kaushik G, Backenroth D, et al. Association of patient characteristics and tumor genomics with clinical outcomes among patients with non-small cell lung cancer using a clinicogenomic database. JAMA. 2019;321:1391–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Frampton GM, Fichtenholtz A, Otto GA, Wang K, Downing SR, He J, et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol. 2013;31:1023–31.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zurita AJ, Graf RP, Villacampa G, Raskina K, Sokol E, Jin D, et al. Genomic biomarkers and genome-wide loss-of-heterozygosity scores in metastatic Prostate Cancer following progression on Androgen-Targeting therapies. JCO Precis Oncol. 2022;6:e2200195.

Article  PubMed  PubMed Central  Google Scholar 

Sayegh N, Swami U, Agarwal N. Recent advances in the management of metastatic prostate cancer. JCO Oncol Pr. 2022;18:45–55.

Google Scholar 

Koshkin VS, Mir MC, Barata P, Gul A, Gupta R, Stephenson AJ, et al. Randomized phase II trial of neoadjuvant everolimus in patients with high-risk localized prostate cancer. Invest N. Drugs. 2019;37:559–66.

Article  CAS  Google Scholar 

Azad AA, Beardsley EK, Hotte SJ, Ellard SL, Klotz L, Chin J, et al. A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naive castration-resistant prostate cancer. Invest N. Drugs. 2014;32:746–52.

Article  CAS  Google Scholar 

Culig Z, Hoffmann J, Erdel M, Eder IE, Hobisch A, Hittmair A, et al. Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. Br J Cancer. 1999;81:242–51.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ku SY, Rosario S, Wang Y, Mu P, Seshadri M, Goodrich ZW, et al. Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance. Science. 2017;355:78–83.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nyquist MD, Corella A, Coleman I, De Sarkar N, Kaipainen A, Ha G, et al. Combined TP53 and RB1 loss promotes prostate cancer resistance to a spectrum of therapeutics and confers vulnerability to replication stress. Cell Rep. 2020;31:107669.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, et al. Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: a multi-institutional prospective study. J Clin Oncol. 2018;36:2492–503.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sweeney C, Bracarda S, Sternberg CN, Chi KN, Olmos D, Sandhu S, et al. Ipatasertib plus abiraterone and prednisolone in metastatic castration-resistant prostate cancer (IPATential150): a multicentre, randomised, double-blind, phase 3 trial. Lancet. 2021;398:131–42.

Article  PubMed  CAS  Google Scholar 

Bono JSD, Sweeney C, Bracarda S, Sternberg CN, Chi KN, Olmos D, et al. PI3K/AKT pathway biomarkers analysis from the phase III IPATential150 trial of ipatasertib plus abiraterone in metastatic castration-resistant prostate cancer. J Clin Oncol. 2021;39:13–13.

Article  Google Scholar 

Choudhury AD. PTEN-PI3K pathway alterations in advanced prostate cancer and clinical implications. Prostate. 2022;82:S60–72.

Article  PubMed  CAS  Google Scholar