Effect of Surgically Acquired Neurological Deficits on Mortality Among Patients with Brain Metastases

Abstract

Purpose: To evaluate the association between surgically acquired neurological deficits and mortality among patients who underwent surgical resection of brain metastases. Methods: Patients who underwent surgical resection of brain metastases at our institution between 2011 and 2019 were included. Surgically acquired neurological deficits were defined as dysarthria/aphasia, ataxia, hemiparesis, and visual field loss. A Cox proportional hazards model adjusting for potential confounders was constructed to evaluate whether surgically acquired neurological deficits were independently associated with a higher risk of overall mortality. Results: A total of 153 patients were included in the analysis. 3.3% (5 patients) had a surgically acquired neurological deficit. On univariate time-to-event analysis, there was no statistically significant association between the development of a surgically acquired neurological deficit and mortality (HR=1.12; 95% CI=0.15, 8.24; p=0.910). On multivariate time-to-event analysis adjusting for potential confounders, there was also no statistically significant association between the development of a surgically acquired neurological deficit and mortality (HR=1.53; 95% CI=0.20, 11.9; p=0.683). Conclusion: The development of a surgically acquired neurological deficit was not associated with overall mortality. Although this conclusion differs from other studies in the literature, the goal of surgical resection remains unchanged; to resect as much tumor as possible while still preserving neurological function.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

None

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

National healthcare group; domain-specific review board

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

All data produced in the present study are available upon reasonable request to the authors

留言 (0)

沒有登入
gif