Purpose: To evaluate the association between surgically acquired neurological deficits and mortality among patients who underwent surgical resection of brain metastases. Methods: Patients who underwent surgical resection of brain metastases at our institution between 2011 and 2019 were included. Surgically acquired neurological deficits were defined as dysarthria/aphasia, ataxia, hemiparesis, and visual field loss. A Cox proportional hazards model adjusting for potential confounders was constructed to evaluate whether surgically acquired neurological deficits were independently associated with a higher risk of overall mortality. Results: A total of 153 patients were included in the analysis. 3.3% (5 patients) had a surgically acquired neurological deficit. On univariate time-to-event analysis, there was no statistically significant association between the development of a surgically acquired neurological deficit and mortality (HR=1.12; 95% CI=0.15, 8.24; p=0.910). On multivariate time-to-event analysis adjusting for potential confounders, there was also no statistically significant association between the development of a surgically acquired neurological deficit and mortality (HR=1.53; 95% CI=0.20, 11.9; p=0.683). Conclusion: The development of a surgically acquired neurological deficit was not associated with overall mortality. Although this conclusion differs from other studies in the literature, the goal of surgical resection remains unchanged; to resect as much tumor as possible while still preserving neurological function.
Competing Interest StatementThe authors have declared no competing interest.
Funding StatementNone
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Yes
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
National healthcare group; domain-specific review board
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Data AvailabilityAll data produced in the present study are available upon reasonable request to the authors
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