Mitochondrial remodeling in cardiovascular disease: Therapeutic potential

In recent years, the mortality rate associated with cardiovascular diseases (CVDs) has consistently increased and has emerged as the primary cause of death worldwide. It is a serious threat to humans, especially in the western world. CVDs are multifactorial disorders including several conditions, such as hypertension, obesity, and diabetes. The patient’s lifestyle, smoking, and consumption of alcohol are the main risk factors for this disease. CVDs comprise several diseases of the heart and blood vessels, such as cardiac hypertrophy, cerebrovascular disease, coronary heart disease, rheumatic heart disease, heart failure, and other conditions. There are various cellular and molecular mechanisms underlying cardiac pathogenesis. Generally, the heart consumes high-energy molecules for its function, which utilizes large amounts of ATP molecules. These molecules are produced by mitochondria through an oxidative phosphorylation mechanism [1, 2].

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