*Department of Pharmacy, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands;

†Department of Clinical Pharmacy, Bernhoven Hospital, Uden, the Netherlands;

Departments of ‡Clinical Pharmacy, Clinical Pharmacology and Toxicology and

§Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre, Sittard-Geleen/Heerlen, the Netherlands;

¶Division of Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, the Netherlands;

‖Department of Methodology and Statistics, Maastricht University Medical Centre, Maastricht, the Netherlands;

**Department of Gastroenterology and Hepatology, Laurentius Hospital, Roermond, the Netherlands; and

††Department of Gastroenterology and Hepatology, AGEM Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Correspondence: Sofia A. W. van Moorsel, PharmD, Department of Pharmacy, Jeroen Bosch Hospital, P.O. box 90153, 5200 ME Den Bosch, the Netherlands (e-mail: [email protected]).

N. K. H. de Boer has served as a speaker for AbbVie and MSD and has served as a consultant and principal investigator for TEVA Pharma BV and Takeda; he has received an (unrestricted) research grant from Falk, TEVA Pharma BV, MLDS, and Takeda. A. A. van Bodegraven served as a speaker, advisor, and/or PI for AbbVie, Arendal, ARENA, Celgene, Ferring, Galapagos, Janssen, MSD, Pfizer, Roche, Takeda, BMS, and TEVA and has received research grants from TEVA, Eurostar funding, ZonMW, and Pfizer. The authors have no other relevant affiliations or involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript, apart from those disclosed.

This study was approved by the Medical Ethics Committee of the Zuyderland Medical Centre, and Zuyd Hogeschool conformed to the ethical guidelines of the Declaration of Helsinki (2013), as reflected in a prior approval by the institution's human research committee (METC number 15T148). Written informed consent was obtained from all patients.