Please visit the ASCB website for PAIR-UP ( https://ascb.org/pair-up/) to learn more about our activities and to join our efforts to change the DEI landscape. I am grateful to the scientists who have joined PAIR-UP and my co-founder, Torsten Woellert. I give special thanks to the Gordon and Betty Moore Foundation, the Burroughs Wellcome Fund, and the Chan Zuckerberg Initiative, which awarded grants to fund the program. I dedicate this article to my granddaughter Mia Langford, who is a constant source of inspiration and joy. The future of science is bright if we seize this moment of reckoning to ensure that scientific careers are available and fulfilling to everyone.