The Evolving Landscape of Viral, Immune, and Molecular Biomarkers in Penile Cancer

Douglawi A. Masterson T.A.

Updates on the epidemiology and risk factors for penile cancer.

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Advances in understanding of penile carcinogenesis: the search for actionable targets.

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Novel targeted therapies for the treatment of penile cancer.

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.

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Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus.

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Human papillomavirus prevalence in invasive penile cancer and association with clinical outcome.

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Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival.

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Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy.

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Human papilloma virus: prevalence, distribution and predictive value to lymphatic metastasis in penile carcinoma.

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The role of histologic subtype, p16(INK4a) expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma.

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Expansion of tumor-infiltrating lymphocytes (TIL) from penile cancer patients.

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Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas.

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The epidermal growth factor receptor is frequently overexpressed in penile squamous cell carcinomas: a tissue microarray and digital image analysis study of 112 cases.

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Genomic profiling of penile squamous cell carcinoma reveals new opportunities for targeted therapy.

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Cytosolic phosphorylated EGFR is predictive of recurrence in early stage penile cancer patients: a retropective study.

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First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: results of an open-label, single-arm, single-centre, phase 2 study.

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Assessment of PI3K/mTOR/AKT pathway elements to serve as biomarkers and therapeutic targets in penile cancer.

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Value of c-MET and associated signaling elements for predicting outcomes and targeted therapy in penile cancer.

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Whole-exome sequencing in penile squamous cell carcinoma uncovers novel prognostic categorization and drug targets similar to head and neck squamous cell carcinoma.

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The prognostic value of immune factors in the tumor microenvironment of penile squamous cell carcinoma.

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Pathologic and imunohistochemical characterization of tumoral inflammatory cell infiltrate in invasive penile squamous cell carcinomas: Fox-P3 expression is an independent predictor of recurrence.

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The immune microenvironment in penile cancer and rationale for immunotherapy.

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Systematic review and meta-analysis-is there a benefit in using neoadjuvant systemic chemotherapy for locally advanced penile squamous cell carcinoma?.

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Frequent PD-L1 expression in primary and metastatic penile squamous cell carcinoma: potential opportunities for immunotherapeutic approaches.

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Pembrolizumab for advanced penile cancer: a case series from a phase II basket trial.

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Case report: two cases of chemotherapy refractory metastatic penile squamous cell carcinoma with extreme durable response to pembrolizumab.

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