Pathophysiology and Clinical Biomarkers in Interstitial Cystitis

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Comorbidity of interstitial cystitis with other unexplained clinical conditions.

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Antecedent nonbladder syndromes in case-control study of interstitial cystitis/painful bladder syndrome.

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Urinary tract infection and inflammation at onset of interstitial cystitis/painful bladder syndrome.

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Role of the immune response in interstitial cystitis.

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Decreased urinary uronic acid levels in individuals with interstitial cystitis.

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Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study.

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The vesical blood-urine barrier: a relevant and dynamic interface between renal function and nervous bladder control.

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Leaky urothelium and/or vesical ischemia enable urinary potassium to cause idiopathic urgency/frequency syndrome and urge incontinence.

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The role of the mast cell in interstitial cystitis.

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Does the mast cell have an intrinsic role in the pathogenesis of interstitial cystitis?.

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The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.

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Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis.

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Interstitial cystitis: correlation with nerve fibres, mast cells and histamine.

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Critical role of mast cells in inflammatory diseases and the effect of acute stress.

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Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

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Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study.

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The MAPP research network: design, patient characterization and operations.

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Pain and Urinary Symptoms Should Not be Combined into a Single Score: Psychometric Findings from the MAPP Research Network.

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Validation of a modified National Institutes of Health chronic prostatitis symptom index to assess genitourinary pain in both men and women.

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The interstitial cystitis symptom index and problem index.

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Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study.

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Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder.

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O-antigen modulates infection-induced pain states.

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Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network.

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Urological chronic pelvic pain syndrome symptom flares: characterisation of the full range of flares at two sites in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.

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Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network.

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Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions.

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The management of interstitial cystitis or painful bladder syndrome in women.

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A prospective, double-blind, randomized cross-over study evaluating changes in urinary pH for relieving the symptoms of interstitial cystitis.

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Caffeine ingestion and lower urinary tract symptoms in healthy volunteers.

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Caffeine intake, and the risk of stress, urgency and mixed urinary incontinence.

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Dietary consumption triggers in interstitial cystitis/bladder pain syndrome patients.

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Effect of comestibles on symptoms of interstitial cystitis.

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Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.

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Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort.

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Toll-like receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study.

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Pathology of interstitial cystitis.

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A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome.

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Urinary proteomics evaluation in interstitial cystitis/painful bladder syndrome: a pilot study.

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Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor: sensitive and specific urine markers for interstitial cystitis.

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Decreased 3H-thymidine incorporation by human bladder epithelial cells following exposure to urine from interstitial cystitis patients.

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A hypothesis for the etiology of interstitial cystitis based upon inhibition of bladder epithelial repair.

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Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis.

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Antiproliferative factor signaling and interstitial cystitis/painful bladder syndrome.

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Quantitative proteomics identifies a beta-catenin network as an element of the signaling response to Frizzled-8 protein-related antiproliferative factor.

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Painful Bladder Filling and Painful Urgency are Distinct Characteristics in Men and Women with Urological Chronic Pelvic Pain Syndromes: A MAPP Research Network Study.

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Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome.

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Anesthetic Bladder Capacity is a Clinical Biomarker for Interstitial Cystitis/Bladder Pain Syndrome Subtypes.

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Histological evidence supports low anesthetic bladder capacity as a marker of a bladder-centric disease subtype in interstitial cystitis/bladder pain syndrome.

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Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion.

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Changes in uroplakin expression in the urothelium of patients with ulcerative interstitial cystitis/bladder pain syndrome.

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Uroplakins in the lower urinary tract.

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Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice.

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Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux.

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Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability.

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Expression profile of urothelial transcription factors in bladder biopsies with interstitial cystitis.

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Alteration of Urothelial Inflammation, Apoptosis, and Junction Protein in Patients with Various Bladder Conditions and Storage Bladder Symptoms Suggest Common Pathway Involved in Underlying Pathophysiology.

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Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome.

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Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome.

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Urine cytokines as biomarkers for diagnosing interstitial cystitis/bladder pain syndrome and mapping its clinical characteristics.

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Urine biomarkers in ESSIC type 2 interstitial cystitis/bladder pain syndrome and overactive bladder with developing a novel diagnostic algorithm.

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A multiplexed analysis approach identifies new association of inflammatory proteins in patients with overactive bladder.

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Elevated Urine Levels of Macrophage Migration Inhibitory Factor in Inflammatory Bladder Conditions: A Potential Biomarker for a Subgroup of Interstitial Cystitis/Bladder Pain Syndrome Patients.

Urology. 116: 55-62

Abnormal functional connectivity within the prefrontal cortex in interstitial cystitis/bladder pain syndrome (IC/BPS): A pilot study using resting state functional near-infrared spectroscopy (rs-fNIRS).

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Are the metabolic alterations associated with critical illness related to the hormonal environment?.

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Bioinformatics Approach for Identifying Novel Biomarkers and Their Signaling Pathways Involved in Interstitial Cystitis/Bladder Pain Syndrome with Hunner Lesion.

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A Randomized, Double-blind, Placebo-controlled Trial of Certolizumab Pegol in Women with Refractory Interstitial Cystitis/Bladder Pain Syndrome.

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Exploration of the core genes in ulcerative interstitial cystitis/bladder pain syndrome.

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Repeated intravesical injections of platelet-rich plasma improve symptoms and alter urinary functional proteins in patients with refractory interstitial cystitis.

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Down regulation of vascular endothelial growth factor is associated with decreased inflammation after intravesical OnabotulinumtoxinA injections combined with hydrodistention for patients with interstitial cystitis--clinical results and immunohistochemistry analysis.

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Effect of Sacral Neuromodulation on Outcome Measures and Urine Chemokines in Interstitial Cystitis/Painful Bladder Syndrome Patients.

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