Available online 21 November 2022

Silanized hydroxyapatite nanofibers loaded with erythromycin ([email protected]) show excellent antibacterial activity.

Resin contained with [email protected] presented mechanical property, antibacterial activity, and remineralization capability.

This new multifunctional dental resin is a promising material to inhibit recurrent caries and restore the minerals.

Secondary caries is the primary issue that causes restoration failure. The objectives of this study were to: (1) synthesize silanized hydroxyapatite nanofibers loaded with erythromycin ([email protected]); (2) evaluate the mechanical property, antibacterial activity, and remineralization capability of the novel dental resin containing [email protected]

s-HAFs were prepared by the solvothermal approach and loaded with EM. Characterization and antibacterial activity were evaluated. Subsequently, [email protected] were incorporated into dental resin at different mass fractions (5 %, 10 %, 15 %, and 20 %), and then they were submitted to characterization, including mechanical property, antibacterial activity, remineralization capability, and cytotoxicity.

[email protected] were successfully synthesized, and they exhibited excellent antibacterial activity. Resin containing 15 % [email protected] exhibited the best flexural strength (118.67 ± 15.71 MPa) and elastic modulus (2.02 ± 0.30 GPa) (P < 0.05), which were increased by 65.43 % and 90.7 %, compared to those of neat resin, respectively. Resin with 15–20 % [email protected] showed high antibacterial rate (>85 %) when compared control group (P < 0.05). Furthermore, resin also exhibited a definite remineralization capability and good biosafety in vitro.

This novel multifunctional resin with improved mechanical property, desirable antibacterial activity and remineralization capability is promising to combat secondary caries.

Hydroxyapatite nanofibers

Silanization

Erythromycin

Resin

Mechanical property

Antibacterial

Remineralization

© 2022 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.