Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis

Al Nimer F, Jelcic I, Kempf C, Pieper T, Budka H, Sospedra M, Martin R (2018) Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis. Neurol Neuroimmunol Neuroinflamm 5:e419. https://doi.org/10.1212/NXI.0000000000000419

Article  PubMed  Google Scholar 

Alquicira-Hernandez J, Powell JE (2021) Nebulosa recovers single-cell gene expression signals by kernel density estimation. Bioinformatics 37:2485–2487. https://doi.org/10.1093/bioinformatics/btab003

Article  CAS  Google Scholar 

Alsegiani AS, Shah ZA (2020) The role of cofilin in age-related neuroinflammation. Neural Regen Res 15:1451–1459. https://doi.org/10.4103/1673-5374.274330

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andoh M, Ikegaya Y, Koyama R (2019) Synaptic pruning by microglia in epilepsy. J Clin Med 8:2170. https://doi.org/10.3390/jcm8122170

Article  CAS  PubMed Central  Google Scholar 

Andoh M, Koyama R (2021) Microglia regulate synaptic development and plasticity. Dev Neurobiol 81:568–590. https://doi.org/10.1002/dneu.22814

Article  PubMed  PubMed Central  Google Scholar 

Audrito V, Messana VG, Deaglio S (2020) NAMPT and NAPRT: two metabolic enzymes with key roles in inflammation. Front Oncol 10:358. https://doi.org/10.3389/fonc.2020.00358

Article  PubMed  PubMed Central  Google Scholar 

Bakken TE, Jorstad NL, Hu Q, Lake BB, Tian W, Kalmbach BE, Crow M, Hodge RD, Krienen FM, Sorensen SA et al (2021) Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature 598:111–119. https://doi.org/10.1038/s41586-021-03465-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barker-Haliski M, White HS (2015) Glutamatergic mechanisms associated with seizures and epilepsy. Cold Spring Harb Perspect Med 5:a022863. https://doi.org/10.1101/cshperspect.a022863

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benmamar-Badel A, Owens T, Wlodarczyk A (2020) Protective microglial subset in development, aging, and disease: lessons from transcriptomic studies. Front Immunol 11:430. https://doi.org/10.3389/fimmu.2020.00430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bien CG, Tiemeier H, Sassen R, Kuczaty S, Urbach H, von Lehe M, Becker AJ, Bast T, Herkenrath P, Karenfort M et al (2013) Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. Epilepsia 54:543–550. https://doi.org/10.1111/epi.12042

Article  CAS  PubMed  Google Scholar 

Cepeda C, Chang JW, Owens GC, Huynh MN, Chen JY, Tran C, Vinters HV, Levine MS, Mathern GW (2015) In Rasmussen encephalitis, hemichannels associated with microglial activation are linked to cortical pyramidal neuron coupling: a possible mechanism for cellular hyperexcitability. CNS Neurosci Ther 21:152–163. https://doi.org/10.1111/cns.12352

Article  PubMed  Google Scholar 

Chitnis T, Khoury SJ (2003) Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. J Allergy Clin Immunol 112(837–849):850. https://doi.org/10.1016/j.jaci.2003.08.025

Article  Google Scholar 

Clarner T, Janssen K, Nellessen L, Stangel M, Skripuletz T, Krauspe B, Hess F-M, Denecke B, Beutner C, Linnartz-Gerlach B et al (2015) CXCL10 triggers early microglial activation in the cuprizone model. J Immunol 194:3400–3413. https://doi.org/10.4049/jimmunol.1401459

Article  CAS  PubMed  Google Scholar 

Czapski GA, Strosznajder JB (2021) Glutamate and GABA in microglia-neuron cross-talk in Alzheimer’s disease. Int J Mol Sci 22:11677. https://doi.org/10.3390/ijms222111677

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eden E, Navon R, Steinfeld I, Lipson D, Yakhini Z (2009) GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 10:48. https://doi.org/10.1186/1471-2105-10-48

Article  PubMed  PubMed Central  Google Scholar 

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ (2014) Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci 34:10528–10540. https://doi.org/10.1523/JNEUROSCI.0416-14.2014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fauser S, Elger CE, Woermann F, Bien CG (2022) Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality. Epilepsia 63:108–119. https://doi.org/10.1111/epi.17131

Article  PubMed  Google Scholar 

Finak G, McDavid A, Yajima M, Deng J, Gersuk V, Shalek AK, Slichter CK, Miller HW, McElrath MJ, Prlic M et al (2015) MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol 16:278. https://doi.org/10.1186/s13059-015-0844-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Moller T, Biber K et al (2021) Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer’s disease. Acta Neuropathol 141:681–696. https://doi.org/10.1007/s00401-021-02263-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA (2015) IQ motif-containing GTPase-activating protein 2 (IQGAP2) Is a novel regulator of colonic inflammation in mice. PLoS ONE 10:e0129314. https://doi.org/10.1371/journal.pone.0129314

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grajchen E, Hendriks JJA, Bogie JFJ (2018) The physiology of foamy phagocytes in multiple sclerosis. Acta Neuropathol Commun 6:124. https://doi.org/10.1186/s40478-018-0628-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hafemeister C, Satija R (2019) Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol 20:296. https://doi.org/10.1186/s13059-019-1874-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M et al (2021) Integrated analysis of multimodal single-cell data. Cell 184(3573–3587):e3529. https://doi.org/10.1016/j.cell.2021.04.048

Article  CAS  Google Scholar 

Janova H, Bottcher C, Holtman IR, Regen T, van Rossum D, Gotz A, Ernst AS, Fritsche C, Gertig U, Saiepour N et al (2016) CD14 is a key organizer of microglial responses to CNS infection and injury. Glia 64:635–649. https://doi.org/10.1002/glia.22955

Article  PubMed  Google Scholar 

Kanehisa M, Sato Y, Kawashima M (2022) KEGG mapping tools for uncovering hidden features in biological data. Protein Sci 31:47–53. https://doi.org/10.1002/pro.4172

Article  CAS  PubMed  Google Scholar 

Karagiannis TT, Monti S, Sebastiani P (2022) Cell type diversity statistic: an entropy-based metric to compare overall cell type composition across samples. Front Genet 13:855076. https://doi.org/10.3389/fgene.2022.855076

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kenkhuis B, Somarakis A, de Haan L, Dzyubachyk O, ME IJ, de Miranda N, Lelieveldt BPF, Dijkstra J, van Roon-Mom WMC, Hollt T, et al (2021) Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients. Acta Neuropathol Commun 9:27. https://doi.org/10.1186/s40478-021-01126-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JE, Ryu HJ, Kim MJ, Kang TC (2014) LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. Cell Death Differ 21:1036–1049. https://doi.org/10.1038/cdd.2014.17

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S et al (2021) PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain 144:2971–2978. https://doi.org/10.1093/brain/awab173

Article  PubMed  PubMed Central  Google Scholar 

Kowal K, Silver R, Slawinska E, Bielecki M, Chyczewski L, Kowal-Bielecka O (2011) CD163 and its role in inflammation. Folia Histochem Cytobiol 49:365–374. https://doi.org/10.5603/fhc.2011.0052

Article  CAS  PubMed  Google Scholar 

Lee-Sayer SSM, Maeshima N, Dougan MN, Dahiya A, Arif AA, Dosanjh M, Maxwell CA, Johnson P (2018) Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells. Eur J Immunol 48:803–814. https://doi.org/10.1002/eji.201747263

Article  CAS  PubMed  Google Scholar 

Liu T, Zhang L, Joo D, Sun SC (2017) NF-kappaB signaling in inflammation. Signal Transduct Target Ther 2:17023. https://doi.org/10.1038/sigtrans.2017.23

Article  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https://doi.org/10.1186/s13059-014-0550-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luan G, Gao Q, Zhai F, Chen Y, Li T (2016) Upregulation of HMGB1, toll-like receptor and RAGE in human Rasmussen’s encephaliti

留言 (0)

沒有登入
gif