Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131:803–20.

Article  PubMed  Google Scholar 

Donaldson SS, Laningham F, Fisher PG. Advances toward an understanding of brainstem gliomas. J Clin Oncol. 2006;24(8):1266–72.

Article  PubMed  Google Scholar 

Ferris SP, Hofmann JW, Solomon DA, Perry A. Characterization of gliomas: from morphology to molecules. Virchows Arch. 2017;471(2):257–69. https://doi.org/10.1007/s00428-017-2181-4.

Article  PubMed  Google Scholar 

Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro Oncol. 2013;15:ii1.

Article  PubMed  PubMed Central  Google Scholar 

Hoffman LM, Van Zanten SEMV, Colditz N, Baugh J, Chaney B, Hoffmann M, et al. Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of Diffuse Intrinsic Pontine Glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries. J Clin Oncol. 2018;36(19):1963–72.

Article  PubMed  PubMed Central  Google Scholar 

Robison NJ, Kieran MW. Diffuse intrinsic pontine glioma: a reassessment. J Neurooncol. 2014;119:7–15.

Article  PubMed  Google Scholar 

Gallitto M, Lazarev S, Wasserman I, Stafford JM, Wolden SL, Terezakis SA, et al. Role of radiation therapy in the management of diffuse intrinsic pontine glioma: a systematic review. Adv Radiat Oncol. 2019;4:520–31.

Article  PubMed  PubMed Central  Google Scholar 

Lassman LP, Arjona VE. Pontine gliomas of childhood. Lancet. 1967;289(7496):913–5.

Article  Google Scholar 

Vanan MI, Eisenstat DD. DIPG in children—What can we learn from the past? Front Oncol. 2015. https://doi.org/10.3389/fonc.2015.00237.

Article  PubMed  PubMed Central  Google Scholar 

Koshy M, Villano JL, Dolecek TA, Howard A, Mahmood U, Chmura SJ, et al. Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Neurooncol. 2012;107(1):207–12.

Article  PubMed  Google Scholar 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–96.

Article  PubMed  Google Scholar 

Ross JL, Velazquez Vega J, Plant A, MacDonald TJ, Becher OJ, Hambardzumyan D. Tumour immune landscape of paediatric high-grade gliomas. Brain. 2021;144:2594–609.

Article  PubMed  PubMed Central  Google Scholar 

Price G, Bouras A, Hambardzumyan D, Hadjipanayis CG. Current knowledge on the immune microenvironment and emerging immunotherapies in diffuse midline glioma. EBioMedicine. 2021;69: 103453.

Article  PubMed  PubMed Central  Google Scholar 

Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H. The brain tumor microenvironment. Glia. 2011;59(8):1169–80.

Article  PubMed  Google Scholar 

Loveson KF, Fillmore HL. Intersection of brain development and paediatric diffuse midline gliomas: potential role of microenvironment in tumour growth. Brain Sci. 2018. https://doi.org/10.3390/brainsci8110200.

Article  PubMed  PubMed Central  Google Scholar 

Mackay A, Burford A, Molinari V, Jones DTW, Izquierdo E, Brouwer-Visser J, et al. Molecular, pathological, radiological, and immune profiling of non-brainstem pediatric high-grade glioma from the HERBY phase II randomized trial. Cancer Cell. 2018;33(5):829-842.e5.

Article  PubMed  PubMed Central  Google Scholar 

Grégoire H, Roncali L, Rousseau A, Chérel M, Delneste Y, Jeannin P, et al. Targeting tumor associated macrophages to overcome conventional treatment resistance in glioblast. Front Pharmacol. 2020. https://doi.org/10.3389/fphar.2020.00368.

Article  PubMed  PubMed Central  Google Scholar 

Kennedy BC, Showers CR, Anderson DE, Anderson L, Canoll P, Bruce JN, et al. Tumor-associated macrophages in glioma: friend or foe? J Oncol. 2013. https://doi.org/10.21037/atm-2020-tam-05.

Article  PubMed  PubMed Central  Google Scholar 

Lieberman NAP, DeGolier K, Kovar HM, Davis A, Hoglund V, Stevens J, et al. Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy. Neuro Oncol. 2019;21(1):83.

Article  PubMed  Google Scholar 

Lin GL, Nagaraja S, Filbin MG, Suvà ML, Vogel H, Monje M. Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma. Acta Neuropathol Commun. 2018;6(1):51. https://doi.org/10.1186/s40478-018-0553-x.

Article  PubMed  PubMed Central  Google Scholar 

Rashed WM, Maher E, Adel M, Saber O, Zaghloul MS. Pediatric diffuse intrinsic pontine glioma: where do we stand? Cancer Metastasis Rev. 2019;38:759–70.

Article  PubMed  Google Scholar 

Warren KE. Diffuse intrinsic pontine glioma: poised for progress. Front Oncol. 2012. https://doi.org/10.3389/fonc.2012.00205.

Article  PubMed  PubMed Central  Google Scholar 

Tisnado J, Young R, Peck KK, Haque S. Conventional and advanced imaging of diffuse intrinsic pontine glioma. J Child Neurol. 2016;31:1386–93.

Article  PubMed  PubMed Central  Google Scholar 

Buczkowicz P, Bartels U, Bouffet E, Becher O, Hawkins C. Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications. Acta Neuropathol. 2014;128(4):573–81. https://doi.org/10.1007/s00401-014-1319-6.

Article  PubMed  PubMed Central  Google Scholar 

Albright AL, Packer RJ, Zimmerman R, Rorke LB, Boyett J, Hammond GD. Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the children’s cancer group. Neurosurgery. 1993;33(6):1026–30.

PubMed  Google Scholar 

Broniscer A, Baker JN, Baker SJ, Chi SN, Geyer JR, Morris EB, et al. Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma. Cancer. 2010;116(19):4632–7.

Article  PubMed  Google Scholar 

Li D, Bonner ER, Wierzbicki K, Panditharatna E, Huang T, Lulla R, et al. Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR. Sci Rep. 2021;11(1):1–10.

Google Scholar 

Pan C, Diplas BH, Chen X, Wu Y, Xiao X, Jiang L, et al. Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA. Acta Neuropathol. 2019;137(2):297–306.

Article  PubMed  Google Scholar 

Stallard S, Savelieff MG, Wierzbicki K, Mullan B, Miklja Z, Bruzek A, et al. CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response. Acta Neuropathol Commun. 2018. https://doi.org/10.1186/s40478-018-0580-7.

Article  PubMed  PubMed Central  Google Scholar 

Azad TD, Jin MC, Bernhardt LJ, Bettegowda C. Liquid biopsy for pediatric diffuse midline glioma: A review of circulating tumor DNA and cerebrospinal fluid tumor DNA. Neurosurg Focus. 2020;48(1):E9.

Article  PubMed  PubMed Central  Google Scholar 

Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A. 2011;108(11):4453.

Article  PubMed  PubMed Central  Google Scholar 

Caretti V, Jansen MHA, van Vuurden DG, Lagerweij T, Bugiani M, Horsman I, et al. Implementation of a multi-institutional diffuse intrinsic pontine glioma autopsy protocol and characterization of a primary cell culture. Neuropathol Appl Neurobiol. 2013;39(4):426–36.

Article  PubMed  Google Scholar 

Cartmill M, Punt J. Diffuse brain stem glioma: A review of stereotactic biopsies. Child’s Nerv Syst. 1999;15(5):235–7.

Article  Google Scholar 

Roujeau T, Machado G, Garnett MR, Miquel C, Puget S, Geoerger B, et al. Stereotactic biopsy of diffuse pontine lesions in children. J Neurosurg. 2007;107(1 SUPPL.):1–4.

PubMed  Google Scholar 

Nikbakht H, Panditharatna E, Mikael LG, Li R, Gayden T, Osmond M, et al. Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nat Commun. 2016. https://doi.org/10.1038/ncomms11185.

Article  PubMed  PubMed Central  Google Scholar 

Caretti V, Bugiani M, Freret M, Schellen P, Jansen M, van Vuurden D, et al. Subventricular spread of diffuse intrinsic pontine glioma. Acta Neuropathol. 2014;128:605–7.

Article  PubMed  PubMed Central  Google Scholar 

Ramón y Cajal S, Sesé M, Capdevila C, Aasen T, De Mattos-Arruda L, Diaz-Cano SJ, et al. Clinical implications of intratumor heterogeneity: challenges and opportunities. J Mol Med. 2020;98:161–77.

Article  PubMed  Google Scholar 

DeCordova S, Shastri A, Tsolaki AG, Yasmin H, Klein L, Singh SK, et al. Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma. Front Immunol. 2020. https://doi.org/10.3389/fimmu.2020.01402.

Article  PubMed  PubMed Central  Google Scholar 

Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND, et al. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science (80-). 2018;360(6386):331–5.

Article