Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clinicians. 2018;68:394–424.

Article  Google Scholar 

Ferrone C, Dranoff G. Dual roles for immunity in gastrointestinal cancers. JCO. 2010;28:4045–51.

Article  CAS  Google Scholar 

Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, et al. Inhibition of hematopoietic cell kinase activity suppresses myeloid cell-mediated colon cancer progression. Cancer Cell. 2017;31:563–575.e5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, et al. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. J Clin Investig. 2015;125:739–51.

Article  PubMed  Google Scholar 

Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020;20:662–80.

Article  CAS  PubMed  Google Scholar 

Saito T, Nishikawa H, Wada H, Nagano Y, Sugiyama D, Atarashi K, et al. Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers. Nat Med. 2016;22:679–84.

Article  CAS  PubMed  Google Scholar 

Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer. Cancer Res. 2011;71:1263–71.

Article  CAS  PubMed  Google Scholar 

Amicarella F, Muraro MG, Hirt C, Cremonesi E, Padovan E, Mele V, et al. Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. Gut. 2017;66:692–704.

Article  CAS  PubMed  Google Scholar 

Maciel TT, Moura IC, Hermine O. The role of mast cells in cancers. F1000Prime Rep. 2015;7. https://facultyopinions.com/prime/reports/m/7/9/.

Malfettone A, Silvestris N, Saponaro C, Ranieri G, Russo A, Caruso S, et al. High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression. J Cell Mol Med. 2013;17:1025–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehdawi L, Osman J, Topi G, Sjölander A. High tumor mast cell density is associated with longer survival of colon cancer patients. Acta Oncol. 2016;55:1434–42.

Article  CAS  PubMed  Google Scholar 

Nielsen HJ, Hansen U, Christensen IJ, Reimert CM, Brünner N, Moesgaard F. Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue. J Pathol. 1999;189:487–95.

Article  CAS  PubMed  Google Scholar 

Mao Y, Feng Q, Zheng P, Yang L, Zhu D, Chang W, et al. Low tumor infiltrating mast cell density confers prognostic benefit and reflects immunoactivation in colorectal cancer: Tumor infiltrating mast cell in colorectal cancer. Int J Cancer. 2018;143:2271–80.

Article  CAS  PubMed  Google Scholar 

Gulubova M, Vlaykova T. Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer. J Gastroenterol Hepatol. 2009;24:1265–75.

Article  PubMed  Google Scholar 

Dudeck A, Köberle M, Goldmann O, Meyer N, Dudeck J, Lemmens S, et al. Mast cells as protectors of health. J Allergy Clin Immunol. 2019;144:S4–18.

Article  CAS  PubMed  Google Scholar 

Yodavudh S, Tangjitgamol S, Puangsa-art S. Prognostic significance of microvessel density and mast cell density for the survival of Thai patients with primary colorectal cancer. J Med Assoc Thai. 2008;91:723–32.

PubMed  Google Scholar 

Blatner NR, Bonertz A, Beckhove P, Cheon EC, Krantz SB, Strouch M, et al. In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci USA 2010;107:6430–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marichal T, Tsai M, Galli SJ. Mast cells: potential positive and negative roles in tumor biology. Cancer Immunol Res. 2013;1:269–79.

Article  CAS  PubMed  Google Scholar 

Tan SY. Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer. World J Gastroenterol. 2005;11:1210.

Article  PubMed  PubMed Central  Google Scholar 

Dabiri S, Huntsman D, Makretsov N, Cheang M, Gilks B, Bajdik C, et al. The presence of stromal mast cells identifies a subset of invasive breast cancers with a favorable prognosis. Mod Pathol. 2004;17:690–5.

Article  PubMed  Google Scholar 

della Rovere F, Granata A, Familiari D, D’Arrigo G, Mondello B, Basile G. Mast cells in invasive ductal breast cancer: different behavior in high and minimum hormone-receptive cancers. Anticancer Res. 2007;27:2465–71.

PubMed  Google Scholar 

Rajput AB, Turbin DA, Cheang MC, Voduc DK, Leung S, Gelmon KA, et al. Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases. Breast Cancer Res Treat. 2008;107:249–57.

Article  PubMed  Google Scholar 

Shikotra A, Ohri CM, Green RH, Waller DA, Bradding P. Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer. Sci Rep. 2016;6. http://www.nature.com/articles/srep38352.

Hempel HA, Cuka NS, Kulac I, Barber JR, Cornish TC, Platz EA, et al. Low intratumoral mast cells are associated with a higher risk of prostate cancer recurrence: mast cells and prostate cancer recurrence. Prostate 2017;77:412–24.

Article  CAS  PubMed  Google Scholar 

Fu H, Zhu Y, Wang Y, Liu Z, Zhang J, Wang Z, et al. Tumor infiltrating mast cells (TIMs) confers a marked survival advantage in nonmetastatic clear-cell renal cell carcinoma. Ann Surg Oncol. 2017;24:1435–42.

Article  PubMed  Google Scholar 

Dantas RCM, de Souza RO, Valverde L de F, Vidal MTA, Sales CBS, et al. Evaluation of mast cell density in the tumor microenvironment in oral epithelial dysplasia and oral squamous cell carcinoma. Appl Immunohistochem Mol Morphol. 2017;25:e83–8.

Lin C, Liu H, Zhang H, Cao Y, Li R, Wu S, et al. Tryptase expression as a prognostic marker in patients with resected gastric cancer. Br J Surg. 2017;104:1037–44.

Article  CAS  PubMed  Google Scholar 

Chan JK, Magistris A, Loizzi V, Lin F, Rutgers J, Osann K, et al. Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer. Gynecol. Oncol. 2005;99:20–5.

Article  CAS  PubMed  Google Scholar 

da Silva EZM, Jamur MC, Oliver C. Mast cell function: a new vision of an old cell. J Histochem Cytochem. 2014;62:698–738.

Article  PubMed  Google Scholar 

Ribatti D. Mast cells and macrophages exert beneficial and detrimental effects on tumor progression and angiogenesis. Immunol Lett. 2013;152:83–8.

Article  CAS  PubMed  Google Scholar 

Rigoni A, Colombo MP, Pucillo C. The role of mast cells in molding the tumor microenvironment. Cancer Microenviron. 2015;8:167–76.

Article  CAS  PubMed  Google Scholar 

Dowling P, Clynes M. Conditioned media from cell lines: a complementary model to clinical specimens for the discovery of disease-specific biomarkers. Proteomics. 2011;11:794–804.

Article  CAS  PubMed  Google Scholar 

Vis MAM, Ito K, Hofmann S. Impact of culture medium on cellular interactions in in vitro co-culture systems. Front Bioeng Biotechnol. 2020;8:911.

Article  PubMed  PubMed Central  Google Scholar 

Kyritsi K, Kennedy L, Meadows V, Hargrove L, Demieville J, Pham L, et al. Mast cells induce ductular reaction mimicking liver injury in mice through mast cell–derived transforming growth factor beta 1 signaling. Hepatology. 2021;73:2397–410.

Article  CAS  PubMed  Google Scholar 

Ma Y, Hwang RF, Logsdon CD, Ullrich SE. Dynamic mast cell–stromal cell interactions promote growth of pancreatic cancer. Cancer Res. 2013;73:3927–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Segura-Villalobos D, Ramírez-Moreno IG, Martínez-Aguilar M, Ibarra-Sánchez A, Muñoz-Bello JO, Anaya-Rubio I, et al. Mast cell–tumor interactions: molecular mechanisms of recruitment, intratumoral communication and potential therapeutic targets for tumor growth. Cells. 2022;11:349.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes MR, McNagny KM. Preface. Mast cells. Methods Mol Biol. 2015;1220:vii–viii.

PubMed  Google Scholar 

Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:220.

Article  PubMed  PubMed Central  Google Scholar 

Hetz C, Papa FR. The unfolded protein response and cell fate control. Mol Cell. 2018;69:169–81.

Article  CAS  PubMed  Google Scholar 

Zhu P, Hu S, Jin Q, Li D, Tian F, Toan S, et al. Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: a mechanism involving calcium overload/XO/ROS/mPTP pathway. Redox Biol. 2018;16:157–68.

Article  CAS