Abdelgawad IA. Epithelial cell adhesion molecule mRNA can be a potential marker to predict metastasis in hepatocellular carcinoma patients. Asian Pac J Cancer Prev. 2020;21:861–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anastasopoulos NT, Lianos GD, Tatsi V, Karampa A, Goussia A, Glantzounis GK. Clinical heterogeneity in patients with non-alcoholic fatty liver disease-associated hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol. 2020;14:1025–33.

Article  CAS  PubMed  Google Scholar 

Baskiran A, Akbulut S. Effect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantation. Hepatol Int. 2020;14:869–80.

Chen Y, Hao X, Sun R, Wei H, Tian Z. Natural killer cell-derived interferon-gamma promotes hepatocellular carcinoma through the epithelial cell adhesion molecule-epithelial-to-mesenchymal transition axis in hepatitis B virus transgenic mice. Hepatology. 2019;69:1735–50.

Article  CAS  PubMed  Google Scholar 

Corso-Díaz X, Jaeger C, Chaitankar V, Swaroop A. Epigenetic control of gene regulation during development and disease: a view from the retina. Prog Retin Eye Res. 2018;65:1–27.

Article  PubMed  PubMed Central  Google Scholar 

Gao S, Gang J, Yu M, Xin G, Tan H. Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer. BMC Cancer. 2021;21:791.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao XY, Li AQ, Shi H, Guo TK, Shen YF, Deng Y, et al. A novel DNA methylation-based model that effectively predicts prognosis in hepatocellular carcinoma. Biosci Rep. 2021;41:BSR20203945.

Hozyasz KK, Mostowska A, Kowal A, Mydlak D, Tsibulski A, Jagodzinski PP. Further evidence of the Association of the Diacylglycerol Kinase Kappa (DGKK) gene with hypospadias. Urol J. 2018;15:272–6.

PubMed  Google Scholar 

Kanda T, Goto T, Hirotsu Y, Masuzaki R, Moriyama M, Omata M. Molecular mechanisms: connections between nonalcoholic fatty liver disease, Steatohepatitis and Hepatocellular Carcinoma. Int J Mol Sci. 2020;21:1525.

Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, et al. Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. World J Gastroenterol. 2015;21:3960–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laugsand EA, Skorpen F, Kaasa S, Sabatowski R, Strasser F, Fayers P, et al. Genetic and non-genetic factors associated with constipation in cancer patients receiving opioids. Clin Transl Gastroenterol. 2015;6:e90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Farmer RW, Yang Y, Martin RC. Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence. BMC Cancer. 2016;16:228.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lima LDP, Machado CJ, Rodrigues J, Vasconcellos LS, Junior EP, Vidigal PVT, et al. Immunohistochemical coexpression of epithelial cell adhesion molecule and alpha-fetoprotein in hepatocellular carcinoma. Can J Gastroenterol Hepatol. 2018;2018:5970852.

Article  PubMed  PubMed Central  Google Scholar 

Liu B, Xiang L, Ji J, Liu W, Chen Y, Xia M, et al. Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2. J Clin Invest. 2021;131:e144801.

Liu JH, Chen PW, Asch SM, Busuttil RW, Ko CY. Surgery for hepatocellular carcinoma: does it improve survival? Ann Surg Oncol. 2004;11:298–303.

Article  PubMed  Google Scholar 

Liu X, Hu X, Kuang Y, Yan P, Li L, Li C, et al. BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade. Cancer Lett. 2017;395:63–71.

Article  CAS  PubMed  Google Scholar 

Long J, Zhang L, Wan X, Lin J, Bai Y, Xu W, et al. A four-gene-based prognostic model predicts overall survival in patients with hepatocellular carcinoma. J Cell Mol Med. 2018;22:5928–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loomba R, Friedman SL, Shulman GI. Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell. 2021;184:2537–64.

Article  CAS  PubMed  Google Scholar 

Lv X, Li L, Lv L, Qu X, Jin S, Li K, et al. HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma. J Exp Clin Cancer Res. 2015;34:133.

Article  PubMed  PubMed Central  Google Scholar 

Mao XH, Ye Q, Zhang GB, Jiang JY, Zhao HY, Shao YF, et al. Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer. World J Surg Oncol. 2021;19:29.

Article  PubMed  PubMed Central  Google Scholar 

Marzese DM, Scolyer RA, Huynh JL, Huang SK, Hirose H, Chong KK, et al. Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis. Hum Mol Genet. 2014;23:226–38.

Article  CAS  PubMed  Google Scholar 

McPherson S, McMullin MF, Mills K. Epigenetics in myeloproliferative neoplasms. J Cell Mol Med. 2017;21:1660–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pal J, Patil V, Mondal B, Shukla S, Hegde AS, Arivazhagan A, et al. Epigenetically silenced GNG4 inhibits SDF1α/CXCR4 signaling in mesenchymal glioblastoma. Genes Cancer. 2016;7:136–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plaz Torres MC, Bodini G, Furnari M, Marabotto E, Zentilin P, Strazzabosco M, et al. Surveillance for hepatocellular carcinoma in patients with non-alcoholic fatty liver disease: universal or selective? Cancers. 2020;12:1422.

Satilmis B, Sahin TT. Hepatocellular carcinoma tumor microenvironment and its implications in terms of anti-tumor immunity: future perspectives for new therapeutics. J Gastrointest Cancer. 2021;52:1198–205.

Shen J, Liu B, Sinclair A, Cunha G, Baskin LS, Choudhry S. Expression analysis of DGKK during external genitalia formation. J Urol. 2015;194:1728–36.

Article  CAS  PubMed  Google Scholar 

Shionoya T, Usuki T, Komenoi S, Isozaki T, Sakai H, Sakane F. Distinct expression and localization of the type II diacylglycerol kinase isozymes δ, η and κ in the mouse reproductive organs. BMC Dev Biol. 2015;15:6.

Article  PubMed  PubMed Central  Google Scholar 

Simon TG, Roelstraete B, Sharma R, Khalili H, Hagström H, Ludvigsson JF. Cancer risk in patients with biopsy-confirmed nonalcoholic fatty liver disease: a population-based cohort study. Hepatology. 2021;74:2410–23.

Article  CAS  PubMed  Google Scholar 

Stravitz RT, Heuman DM, Chand N, Sterling RK, Shiffman ML, Luketic VA, et al. Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome. Am J Med. 2008;121:119–26.

Article  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Tabuse M, Ohta S, Ohashi Y, Fukaya R, Misawa A, Yoshida K, et al. Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. Mol Cancer. 2011;10:60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanaka H, Kanda M, Miwa T, Umeda S, Sawaki K, Tanaka C, et al. G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer. Br J Cancer. 2021;125:220–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Udali S, Guarini P, Ruzzenente A, Ferrarini A, Guglielmi A, Lotto V, et al. DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma. Clin Epigenetics. 2015;7:43.

Article  PubMed  PubMed Central  Google Scholar 

Wang H, Feng C, Lu M, Zhang B, Xu Y, Zeng Q, et al. Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients. Transl Oncol. 2021;14:100981.

Article  CAS  PubMed  Google Scholar 

Wang J, Ding ZW, Chen K, Liu YZ, Li N, Hu MG. A predictive and prognostic model for hepatocellular carcinoma with microvascular invasion based TCGA database genomics. BMC Cancer. 2021;21:1337.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen D, Wang L, Tan S, Tang R, Xie W, Liu S, et al. HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1. Panminerva Med. 2020. https://doi.org/10.23736/S0031-0808.20.03911-7.

Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 2008;68:1451–61.

Article  CAS  PubMed  Google Scholar 

Younossi ZM, Otgonsuren M, Henry L, Venkatesan C, Mishra A, Erario M, et al. Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009. Hepatology. 2015;62:1723–30.

Article  CAS  PubMed  Google Scholar 

Zhang T, Yuan K, Wang Y, Xu M, Cai S, Chen C, et al. Identification of candidate biomarkers and prognostic analysis in colorectal cancer liver metastases. Front Oncol. 2021;11:652354.

Article  PubMed  PubMed Central