Splenic irradiation combined with plasmapheresis and rituximab: a new option reducing donor-specific antibody in haploidentical hematopoietic stem cell transplantation

Mhandire K, Saggu K, Buxbaum NP. Immunometabolic therapeutic targets of graft-versus-host disease (GvHD). Metabolites. 2021;11. https://doi.org/10.3390/metabo11110736.

Ciurea SO, Al Malki MM, Kongtim P, Zou J, Aung FM, Rondon G, et al. Treatment of allosensitized patients receiving allogeneic transplantation. Blood Adv. 2021;5:4031–43. https://doi.org/10.1182/bloodadvances.2021004862.

Article  PubMed  PubMed Central  Google Scholar 

Yoshihara S, Maruya E, Taniguchi K, Kaida K, Kato R, Inoue T, et al. Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated haploidentical SCT. Bone Marrow Transpl. 2012;47:508–15. https://doi.org/10.1038/bmt.2011.131.

Article  Google Scholar 

Ciurea SO, Cao K, Fernandez-Vina M, Kongtim P, Malki MA, Fuchs E, et al. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. Bone Marrow Transpl. 2018;53:521–34. https://doi.org/10.1038/s41409-017-0062-8.

Article  Google Scholar 

Sicard A, Phares TW, Yu H, Fan R, Baldwin WM 3rd, Fairchild RL, et al. The spleen is the major source of antidonor antibody-secreting cells in murine heart allograft recipients. Am J Transpl. 2012;12:1708–19. https://doi.org/10.1111/j.1600-6143.2012.04009.x.

Article  Google Scholar 

Richard C, Romón I, Perez-Encinas M, Baro J, Rabuñal MJ, Mazorra F, et al. Splenectomy for poor graft function after allogeneic bone marrow transplantation in patients with chronic myeloid leukemia. Leukemia. 1996;10:1615–8.

PubMed  Google Scholar 

Orandi BJ, Lonze BE, Jackson A, Terezakis S, Kraus ES, Alachkar N, et al. Splenic irradiation for the treatment of severe antibody-mediated rejection. Am J Transpl. 2016;16:3041–5. https://doi.org/10.1111/ajt.13882.

Article  Google Scholar 

Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W, et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transpl. 2006;38:291–7. https://doi.org/10.1038/sj.bmt.1705445.

Article  Google Scholar 

Zhu L, Guo Z, Sa R, Guo H, Li J, Chen G. Case report: splenic irradiation for the treatment of chronic active antibody-mediated rejection in kidney allograft recipients with de novo donor-specific antibodies. Front Immunol. 2021;12:661614. https://doi.org/10.3389/fimmu.2021.661614.

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto T, Watarai Y, Takeda A, Tsujita M, Hiramitsu T, Goto N, et al. De novo anti-HLA DSA characteristics and subclinical antibody-mediated kidney allograft injury. Transplantation. 2016;100:2194–202. https://doi.org/10.1097/tp.0000000000001012.

Article  PubMed  Google Scholar 

McManigle W, Youssef A, Sarantopoulos S. B cells in chronic graft-versus-host disease. Hum Immunol. 2019;80:393–9. https://doi.org/10.1016/j.humimm.2019.03.003.

Article  PubMed  PubMed Central  Google Scholar 

Weinmann M, Becker G, Einsele H, Bamberg M. Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases. Strahlenther Onkol. 2001;177:105–11. https://doi.org/10.1007/pl00002384.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif