Okusu H, Ma D, Nikaido H. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J Bacteriol. 1996;178:306 https://doi.org/10.1128/jb.178.1.306-308.1996

Article  CAS  PubMed  PubMed Central  Google Scholar 

Isturiz RE. Optimizing antimicrobial prescribing. Int J Antimicrob Agents. 2010;36:S19–S22. https://doi.org/10.1016/S0924-8579(10)70006-6

Article  CAS  PubMed  Google Scholar 

Peterson E, Kaur P. Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol. 2018;9:2928 https://doi.org/10.3389/fmicb.2018.02928

Article  PubMed  PubMed Central  Google Scholar 

Guyton KZ, Kensler TW. Oxidative mechanism in carcinogenesis. Br Med Bull. 1993;49:523–44. https://doi.org/10.1093/oxfordjournals.bmb.a072628

Article  CAS  PubMed  Google Scholar 

Singh A, Fong G, Liu J, Wu YH, Chang K, Park W, et al. Synthesis and preliminary antimicrobial analysis of isatin−ferrocene and isatin−ferrocenyl chalcone conjugates. ACS Omega. 2018;3:5808–5813. https://doi.org/10.1021/acsomega.8b00553

Article  CAS  PubMed  PubMed Central  Google Scholar 

Recnik LM, Kandioller W, Mindt TL. 1, 4-Disubstituted 1, 2, 3-triazoles as amide bond surrogates for the stabilisation of linear peptides with biological activity. Molecules. 2020;25:3576 https://doi.org/10.3390/molecules25163576

Article  CAS  PubMed Central  Google Scholar 

Whiting M, Muldoon J, Lin YC, Silverman SM, Lindstron W, Olson AJ, et al. Inhibitors of HIV-1 protease by using in situ click chemistry. Angew Chem. 2006;118:1463–7. https://doi.org/10.1002/ange.200502161

Article  Google Scholar 

Sampat S, Vadivelu M, Ravindran R, Perumal PT, Velkannan V, Karthikeyan K. Synthesis of 1,2,3-triazole tethered 3-hydroxy-2-oxindoles: promising corrosion inhibitors for steel in acidic medium and their anti-microbial evaluation. ChemistrySelect. 2020;5:2130–4. https://doi.org/10.1002/slct.201904320

Article  CAS  Google Scholar 

Deswal S, Naveen, Tittal RK, Ghule VD, Lal K, Kumar A. 5-Fluoro-1H-indole-2,3-dione-triazoles- synthesis, biological activity, molecular docking, and DFT study. J Mol Struct. 2020;1209:127982 https://doi.org/10.1016/j.molstruc.2020.127982

Article  CAS  Google Scholar 

Mazzotta S, Cebrero-Cangueiro T, Frattaruolo L, Vega-Holm M, CarreteroLedesma M, Sánchez-Céspedes J, et al. Exploration of piperazine-derived thioureas as antibacterial and anti-inflammatory agents. In vitro evaluation against clinical isolates of colistin-resistant Acinetobacter baumannii. Bioorg Med Chem Lett. 2020;30:127411 https://doi.org/10.1016/j.bmcl.2020.127411

Article  CAS  PubMed  Google Scholar 

Poonia N, Lal K, Kumar A. Design, synthesis, antimicrobial evaluation and in silico studies of symmetrical bis (urea-1,2,3-triazole) hybrids. Res Chem Intermed. 2021;47:1087–10103. https://doi.org/10.1007/s11164-020-04318-1

Article  CAS  Google Scholar 

Moussaoui O, Bhadane R, Sghyar R, Ilas J, Hadrami EME, Chakroune S et al. Design, synthesis, in vitro and in silico characterization of new 2‐quinolone‐L‐alaninate‐1, 2, 3‐triazoles as novel antimicrobial agents. ChemMedChem. 2022;17:e202100714 https://doi.org/10.1002/cmdc.202100714

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shafie A, Mohammadi-Khanaposhtani M, Asadi M, Rahimi N, Ranjbar PR, Ghasemi JB, et al. Novel fused 1, 2, 3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations. Mol Divers. 2020;24:179–89. https://doi.org/10.1007/s11030-019-09940-9

Article  CAS  PubMed  Google Scholar 

Patil PS, Kasare SL, Haval NB, Khedkar VM, Dixit PP, Rekha EM, et al. Novel isoniazid embedded triazole derivatives: synthesis, antitubercular and antimicrobial activity evaluation. Bioorg Med Chem Lett. 2020;30:127434 https://doi.org/10.1016/j.bmcl.2020.127434

Article  CAS  PubMed  Google Scholar 

Garg A, Borah D, Trivedi P, Gogoi D, Chaliha AK, Ali AA, et al. A simple work-up-free, solvent-free approach to novel amino acid linked 1,4-disubstituted 1,2,3-triazoles as potent antituberculosis agents. ACS Omega. 2020;5:29830–29837. https://doi.org/10.1021/acsomega.0c03862

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girase PS, Dhawan S, Kumar V, Shinde SR, Palkar MB, Karpoormath R. An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: a review. Eur J Med Chem. 2021;210:112967 https://doi.org/10.1016/j.ejmech.2020.112967

Article  CAS  PubMed  Google Scholar 

Deswal L, Verma V, Kumar D, Kaushik CP, Kumar A, Deswal Y, et al. Synthesis and antidiabetic evaluation of benzimidazole‐tethered 1, 2, 3‐triazoles. Arch Pharm. 2020;2020:e2000090 https://doi.org/10.1002/ardp.202000090

Article  CAS  Google Scholar 

Theeramunkong S, Thiengsusuk A, Vajragupta O, Muhamad P. Synthesis, characterization and antimalarial activity of isoquinoline derivatives. Med Chem Res 2021;30:109–19. https://doi.org/10.1007/s00044-020-02642-0

Article  CAS  Google Scholar 

Kaushik CP, Chahal M. Synthesis, antimalarial and antioxidant activity of coumarin appended 1, 4-disubstituted 1, 2, 3-triazoles. Monatsh Chem. 2021;152:1001–12. https://doi.org/10.1007/s00706-021-02821-8

Article  CAS  Google Scholar 

Kandula MKR, Gundluru M, Nemallapudi BR, Gundala S, Kotha P, Zyryanov GV, et al. Synthesis, antioxidant activity, and α-glucosidase enzyme inhibition of α-aminophosphonate derivatives bearing piperazine-1,2,3-triazole moiety. J Heterocycl Chem. 2021;58:172–81. https://doi.org/10.1002/jhet.4157

Article  CAS  Google Scholar 

Reddivari CKR, Devineni SR, Nemallapudi BR, Sravya G, Avula B, Shaik N, et al. Design, synthesis, biological evaluation and molecular docking studies of 1,4-disubstituted 1,2,3-triazoles: peg-400:h2o mediated click reaction of fluorescent organic probes under ultrasonic irradiation. Polycycl Aromat Compd. 2021. https://doi.org/10.1080/10406638.2021.1878246

Nural Y, Ozdemir S, Yalcin MS, Demir B, Atabey H, Seferoglu Z, et al. New bis-and tetrakis-1, 2, 3-triazole derivatives: synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants. Bioorg Med Chem Lett. 2022;55:128453 https://doi.org/10.1016/j.bmcl.2021.128453

Article  CAS  PubMed  Google Scholar 

Shinoda K, Kanai M, Sohma Y. Design, synthesis, and properties of a chemically-tethered amyloid-# segment trimer resistant to inter-trimer mis-aggregation. J Org Chem. 2020;85:1635–43. https://doi.org/10.1021/acs.joc.9b02612

Article  CAS  PubMed  Google Scholar 

Kaushik CP, Sangwan J, Luxmi R, Kumar D, Kumar D, Das A, et al. Design, synthesis, anticancer and antioxidant activities of amide linked 1,4-disubstituted 1,2,3-triazoles. J Mol Struct. 2021;1226:129255 https://doi.org/10.1016/j.molstruc.2020.129255

Article  CAS  Google Scholar 

Suryanarayana K, Robert AR, Kerru N, Pooventhiran T, Thomas R, Maddila S, et al. Design, synthesis, anticancer activity and molecular docking analysis of novel dinitrophenylpyrazole bearing 1, 2, 3-triazoles. J Mol Struct. 2021;1243:130865 https://doi.org/10.1016/j.molstruc.2021.130865

Article  CAS  Google Scholar 

Begam R, Shajahan A, Vadivelu M. Synthesis of novel naphthalimide tethered 1, 2, 3-triazoles: in vitro biological evaluation and docking study of anti-inflammatory inhibitors. J Mol Struct. 2022;1254:132364 https://doi.org/10.1016/j.molstruc.2022.132364

Article  CAS  Google Scholar 

Pertino MW, Torre AFDL, Hirschmann GS, Vega C, Rolon M, Coronel C, et al. Synthesis, trypanocidal and anti-leishmania activity of new triazole-lapachol and nor-lapachol hybrids. Bioorg Chem. 2020;103:104122 https://doi.org/10.1016/j.bioorg.2020.104122

Article  CAS  PubMed  Google Scholar 

El-Sayed WA, Khalaf HS, Mohamed SF, Hussien HA, Kutkat OM, Amr AE. Synthesis and antiviral activity of 1, 2, 3-triazole glycosides based substituted pyridine via click cycloaddition. Russ J Gen Chem. 2017;87:2444–53. https://doi.org/10.1134/S1070363217100279

Article  CAS  Google Scholar 

Kumar H, Devaraji V, Joshi R, Jadhao M, Ahirkar P, Prasath R, et al. Antihypertensive activity of a quinoline appended chalcone derivative and its site specific binding interaction with a relevant target carrier protein. RSC Adv. 2015;5:65496–513. https://doi.org/10.1039/C5RA08778C

Article  CAS  Google Scholar 

Cherif M, Horchani M, Ghamdi YOA, Almalki SG, Alqurashi YE, Jannet HB, et al. New pyrano-1,2,3-triazolopyrimidinone derivatives as anticholinesterase and antibacterial agents: Design, microwave-assisted synthesis and molecular docking study. J Mol Struct. 2020;1220:128685 https://doi.org/10.1016/j.molstruc.2020.128685

Article  CAS  Google Scholar 

Igual MO, Nunes PSG, Costa RMD, Mantoani SP, Tostes RC, Carvalho I.Novel glucopyranoside C2-derived 1,2,3-triazoles displaying selective inhibition of O-GlcNAcase (OGA).Carbohydr Res.2019;471:43–55. https://doi.org/10.1016/j.carres.2018.10.007

Article  CAS  PubMed  Google Scholar 

Saghanezhad SJ, Buhamidi MM, Ebadi S, Taheri N, Sayyahi S. Entangled nanofbrous copper: an effcient and high performance nanostructured catalyst in azide-alkyne cycloaddition reaction and reduction of nitroarenes and aromatic aldehydes. React Kinet Mech Catal. 2021;133:897–911. https://doi.org/10.1007/s11144-021-02011-x

Article  CAS  Google Scholar 

Barman K, Dutta P, Chowdhury D, Baruah PK. Green biosynthesis of copper oxide nanoparticles using waste colocasia esculenta leaves extract and their application as recyclable catalyst towards the synthesis of 1,2,3-triazoles. Bionanoscience. 2021;11:189–99. https://doi.org/10.1007/s12668-021-00826-5

Article  Google Scholar 

Huisgen R, Szeimies G, Mobius L. 1.3-Dipolare cycloadditionen, XXXII. Kinetik der additionen organischer azide an CC-mehrfachbindungen. Chem Ber. 1967;100:2494–507. https://doi.org/10.1002/cber.19671000806

Article  CAS  Google Scholar 

Tornøe CW, Christensen C, Meldal M. Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. J Org Chem. 2002;67:3057–64. https://doi.org/10.1021/jo011148j

Article  CAS  PubMed  Google Scholar 

Rostovtsev VV, Green LG, Fokin VV, Sharpless KB. A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective “ligation” of azides and terminal alkynes. Angew Chem Int Ed. 2002;41:2596–9. https://doi.org/10.1002/1521-3773(20020715)41:14%3C2596::aid-anie2596%3E3.0.co;2-4

Article  CAS