Barriers to IOP-independent treatments in glaucoma clinical trials

Lee PP. A multicenter, Retrospective Pilot Study of resource use and costs associated with severity of disease in glaucoma. Arch Ophthalmol. 2006;124:12–9.

Article  PubMed  Google Scholar 

Leske MC, Connell AM, Wu SY, Hyman LG, Schachat AP. Risk factors for open-angle glaucoma: The Barbados eye Study. Arch Ophthalmol. 1995;113:918–24.

Article  CAS  PubMed  Google Scholar 

Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA. The ocular hypertension treatment study. Arch Ophthalmol. 2002;120:714.

Article  PubMed  Google Scholar 

Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma. JAMA 2014;311:1901–11.

Article  PubMed  PubMed Central  Google Scholar 

Garway-Heath DF, Lascaratos G, Bunce C, Crabb DP, Russell RA, Shah A. The United Kingdom Glaucoma Treatment Study. Ophthalmology. 2013;120:68–76.

Article  PubMed  Google Scholar 

Schehlein EM, Kaleem MA, Swamy R, Saeedi OJ. Microinvasive glaucoma surgery: An evidence-based assessment. Expert Rev Ophthalmol. 2017;12:331–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cvenkel B, Kolko M. Current medical therapy and future trends in the management of glaucoma treatment. J Ophthalmol. 2020:6138132. https://doi.org/10.1155/2020/6138132.

Corral-Domenge C, de la Villa P, Mansilla A, Germain F. Tools and biomarkers for the study of retinal ganglion cell degeneration. Int J Mol Sci. 2022;23:4287.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gracitelli CP, Tatham AJ, Zangwill LM, Weinreb RN, Liu T, Medeiros FA Estimated rates of retinal ganglion cell loss in glaucomatous eyes with and without optic disc hemorrhages. PLoS ONE. 2014;9. https://doi.org/10.1371/journal.pone.0105611.

Wu Z, Medeiros FA. Sample size requirements of glaucoma clinical trials when using combined optical coherence tomography and visual field endpoints. Sci Rep. 2019;9:18886.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girard MJA, Schmetterer L. Artificial Intelligence and deep learning in glaucoma: Current state and future prospects. Prog Brain Res. 2020;257:37–64.

Article  PubMed  Google Scholar 

Hood DC, La Bruna S, Tsamis E, Thakoor KA, Rai A, Leshno A, et al. Detecting glaucoma with only Oct: Implications for the clinic, research, screening, and AI development. Prog Retinal Eye Res. 2022;90:101052.

Article  CAS  Google Scholar 

Zawadzki RJ, Jones SM, Olivier SS, Zhao M, Bower BA, Izatt JA, et al. Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. Opt Express. 2005;13:8532–46.

Article  PubMed  Google Scholar 

Zollet P, Yap TE, Cordeiro MF. Detecting apoptosis as a clinical endpoint for proof of a clinical principle. Ophthalmologica 2021;244:408–17.

Article  PubMed  Google Scholar 

Fang CEH, Guo L, Hill D, Yap TE, Cordeiro MF. Neuroprotective Strategies in Glaucoma - Translation to Clinical Trials. OBM Neurobiology. 2020;4:062. https://doi.org/10.21926/obm.neurobiol.2002062.

Almasieh M, Levin LA. Neuroprotection in glaucoma: Animal Models and clinical trials. Annu Rev Vis Sci. 2017;3:91–120.

Article  PubMed  Google Scholar 

Hare WA, WoldeMussie E, Lai RK, Ton H, Ruiz G, Chun T, et al. Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures. Investig Opthalmol Vis Sci. 2004;45:2625–39.

Article  Google Scholar 

Tribble JR, Otmani A, Sun S, Ellis SA, Cimaglia G, Vohra R, et al. Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction. Redox Biol. 2021;43:101988.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans DW, Hosking SL, Gherghel D, Bartlett JD. Contrast sensitivity improves after brimonidine therapy in primary open-angle glaucoma: A case for neuroprotection. Br J Ophthalmol. 2003;87:1463–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krupin T, Liebmann JM, Greenfield DS, Ritch R, Gardiner S. A randomized trial of brimonidine versus timolol in preserving visual function: Results from the low-pressure glaucoma treatment study. Am J Ophthalmol. 2011;151:671–81.

Article  CAS  PubMed  Google Scholar 

Eckert A, Keil U, Scherping I, Hauptmann S, Muller WE. Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by ginkgo biloba extract EGB 761. Ann N. Y Acad Sci. 2005;1056:474–85.

Article  PubMed  Google Scholar 

Parisi V, Centofanti M, Gandolfi S, Marangoni D, Rossetti L, Tanga L, et al. Effects of coenzyme Q10 in conjunction with vitamin E on retinal-evoked and cortical-evoked responses in patients with open-angle glaucoma. J Glaucoma. 2014;23:391–404.

Article  PubMed  Google Scholar 

Citicoline. Alternative Medicine Review. 2008;13:50–7. https://altmedrev.com/wp-content/uploads/2019/02/v13-1-50.pdf.

Parisi V, Centofanti M, Ziccardi L, Tanga L, Michelessi M, Roberti G, et al. Treatment with Citicoline Eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma. Graefe’s Arch Clin Exp Ophthalmol. 2015;253:1327–40.

Article  CAS  Google Scholar 

Pasquin S, Sharma M, Gauchat J-F. Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. Cytokine Growth Factor Rev. 2015;26:507–15.

Article  CAS  PubMed  Google Scholar 

Takahama S, Adetunji MO, Zhao T, Chen S, Li W, Tomarev SI. Retinal astrocytes and GABAergic wide-field amacrine cells express pdgfrα: Connection to retinal ganglion cell neuroprotection by PDGF-AA. Investig Ophthalmol Vis Sci. 2017;58:4703–11.

Article  CAS  Google Scholar 

Holan V, Hermankova B, Krulova M, Zajicova A. Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy. World J Stem Cells. 2019;11:957–67.

Article  PubMed  PubMed Central  Google Scholar 

Gupta V, Mahalingam K, Chaurasia AK, Gowtham L, Gupta S, Somarajan BI, et al. Therapeutic potential of valproic acid in advanced glaucoma: A pilot study. Indian J Ophthalmol. 2018;66:1104–8.

Article  PubMed  PubMed Central  Google Scholar 

Ratican SE, Osborne A, Martin KR. Progress in gene therapy to prevent retinal ganglion cell loss in glaucoma and Leber’s hereditary optic neuropathy. Neural Plast. 2018;2018:11.

Article  Google Scholar 

留言 (0)

沒有登入
gif