cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3

Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995;83:1243–52.

Hrdinka M, Yabal M. Inhibitor of apoptosis proteins in human health and disease. Genes Immun. 2019;20:641–50.

PubMed  Google Scholar 

Dumetier B, Zadoroznyj A, Dubrez L IAP-mediated protein ubiquitination in regulating cell signaling. Cells 2020;9:1118.

Zadoroznyj A, Dubrez L Cytoplasmic and nuclear functions of cIAP1. Biomolecules 2022;12:322.

Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 2006;125:1253–67.

CAS  PubMed  PubMed Central  Google Scholar 

Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, et al. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. Cancer Res. 2009;69:2559–67.

CAS  PubMed  PubMed Central  Google Scholar 

Cheng L, Zhou Z, Flesken-Nikitin A, Toshkov IA, Wang W, Camps J, et al. Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2, and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene 2010;29:5700–11.

CAS  PubMed  PubMed Central  Google Scholar 

Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, et al. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun. 2015;6:5930.

CAS  PubMed  Google Scholar 

Yin Q, Lamothe B, Darnay BG, Wu H. Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry. 2009;48:10558–67.

CAS  PubMed  Google Scholar 

Dhillon B, Aleithan F, Abdul-Sater Z, Abdul-Sater AA. The evolving role of TRAFs in mediating inflammatory responses. Front Immunol. 2019;10:104.

CAS  PubMed  PubMed Central  Google Scholar 

Marivin A, Berthelet J, Cartier J, Paul C, Gemble S, Morizot A, et al. cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene 2014;33:5534–45.

CAS  PubMed  Google Scholar 

Vischioni B, Giaccone G, Span SW, Kruyt FA, Rodriguez JA. Nuclear shuttling and TRAF2-mediated retention in the cytoplasm regulate the subcellular localization of cIAP1 and cIAP2. Exp Cell Res. 2004;298:535–48.

CAS  PubMed  Google Scholar 

Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, et al. IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Rep. 2013;3:724–33.

CAS  PubMed  PubMed Central  Google Scholar 

Dupoux A, Cartier J, Cathelin S, Filomenko R, Solary E, Dubrez-Daloz L. cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand. Blood 2009;113:175–85.

CAS  PubMed  PubMed Central  Google Scholar 

Kreckel J, Anany MA, Siegmund D, Wajant H. TRAF2 controls death receptor-induced Caspase-8 processing and facilitates proinflammatory signaling. Front Immunol. 2019;10:2024.

CAS  PubMed  PubMed Central  Google Scholar 

Mace PD, Smits C, Vaux DL, Silke J, Day CL. Asymmetric recruitment of cIAPs by TRAF2. J Mol Biol. 2010;400:8–15.

CAS  PubMed  Google Scholar 

Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell. 2010;38:101–13.

PubMed  PubMed Central  Google Scholar 

Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999;13:1297–308.

CAS  PubMed  PubMed Central  Google Scholar 

Tang Z, Li C, Kang B, Gao G, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98–102.

CAS  PubMed  PubMed Central  Google Scholar 

Csomos RA, Brady GF, Duckett CS. Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem. 2009;284:20531–9.

CAS  PubMed  PubMed Central  Google Scholar 

Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008;9:1364–70.

CAS  PubMed  PubMed Central  Google Scholar 

Li X, Yang Y, Ashwell JD. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 2002;416:345–7.

PubMed  Google Scholar 

Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, et al. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008;321:663–8.

CAS  PubMed  PubMed Central  Google Scholar 

Shu HB, Takeuchi M, Goeddel DV. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc Natl Acad Sci USA. 1996;93:13973–8.

CAS  PubMed  PubMed Central  Google Scholar 

Borghi A, Verstrepen L, Beyaert R. TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death. Biochem Pharm. 2016;116:1–10.

CAS  PubMed  Google Scholar 

Ceccarelli A, Di Venere A, Nicolai E, De Luca A, Minicozzi V, Rosato N, et al. TNFR-associated Factor-2 (TRAF2): Not only a trimer. Biochemistry 2015;54:6153–61.

CAS  PubMed  Google Scholar 

Ye H, Park YC, Kreishman M, Kieff E, Wu H. The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell. 1999;4:321–30.

CAS  PubMed  Google Scholar 

Park HH. Structure of TRAF family: Current understanding of receptor recognition. Front Immunol. 2018;9:1999.

PubMed  PubMed Central  Google Scholar 

Peng C, Zhu F, Wen W, Yao K, Li S, Zykova T, et al. Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway. J Biol Chem. 2012;287:25881–92.

CAS  PubMed  PubMed Central  Google Scholar 

Dubrez L, Berthelet J, Glorian V. IAP proteins as targets for drug development in oncology. OncoTargets Ther. 2013;9:1285–304.

Google Scholar 

Park MH, Hong JT. Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches. Cells 2016;5:15.

Vu NT, Park MA, Shultz MD, Bulut GB, Ladd AC, Chalfant CE. Caspase-9b interacts directly with cIAP1 to drive agonist-independent activation of NF-κB and lung tumorigenesis. Cancer Res. 2016;76:2977–89.

CAS  PubMed  PubMed Central  Google Scholar 

Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, et al. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell. 2007;28:914–22.

CAS  PubMed  Google Scholar 

Li H, Fang Y, Niu C, Cao H, Mi T, Zhu H, et al. Inhibition of cIAP1 as a strategy for targeting c-MYC-driven oncogenic activity. Proc Natl Acad Sci USA. 2018;115:E9317–24.

CAS  PubMed  PubMed Central  Google Scholar 

Bishop GA, Abdul-Sater AA, Watts TH. Editorial: TRAF proteins in health and disease. Front Immunol. 2019;10:326.

CAS  PubMed  PubMed Central  Google Scholar 

Sondarva G, Kundu CN, Mehrotra S, Mishra R, Rangasamy V, Sathyanarayana P, et al. TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation. Cell Res. 2010;20:89–98.

CAS  PubMed  Google Scholar 

Korchnak AC, Zhan Y, Aguilar MT, Chadee DN. Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. Cell Signal. 2009;21:1620–5.

CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Conze DB, Hanover JA, Ashwell JD. Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling. J Biol Chem. 2007;282:7777–82.

CAS  PubMed  Google Scholar 

Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, et al. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell. 1998;2:389–95.

CAS  PubMed  Google Scholar 

Chadee DN, Yuasa T, Kyriakis JM. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol. 2002;22:737–49.

CAS  PubMed  PubMed Central  Google Scholar 

Annibaldi A, Meier P. Checkpoints in TNF-induced cell death: implications in inflammation and cancer. Trends Mol Med. 2018;24:49–65.

CAS  PubMed  Google Scholar 

Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, et al. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat Cell Biol. 2008;10:1447–55.

CAS  PubMed  Google Scholar 

Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, and TRAF3 and the kinase NIK. Nat Immunol. 2008;9:1371–8.

CAS  PubMed  PubMed Central  Google Scholar 

Johnson DE, O’Keefe RA, Grandis JR. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15:234–48.

CAS  PubMed  PubMed Central 

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