How effective are commercialized products used in the treatment of superficial partial-thickness burn injuries? - Systematic Review with Meta-analysis

Abstract

Burns are an important public health issue, related to 11 million cases annually around the world and up to 180 thousand direct or indirect deaths. Thus, it is vitally important to understand the effectiveness of the different products commercialized for the treatment of burn injuries. Objectives: To analyze the effectiveness of products used in the treatment of superficial-type partial-thickness burn injuries. Methods: This is a systematic review, using the PICO strategy, with a search period between 2004 and 2020, consulting the COCHRANE Library, Lilacs, Medline, PubMed and Scielo databases. The inclusion criteria were studies that used commercialized products for the treatment of superficial-type partial-thickness burn injuries in humans. To assess the quality and risk of bias of the studies, the Oxford scale and criteria from the Cochrane Guidelines were used. Results: 19 eligible studies were selected, most of the products were presented as an alternative to the traditional treatment that involves the use of the silver sulfadiazine product. The methodological quality of the studies allowed performing a meta-analysis of only 2 studies, evaluating the healing outcome, the low number of studies included for statistical analysis suggests that it is not possible to conclude which product is more effective. Conclusions: There is a limitation in the available studies that address the costs and outcomes of existing interventions for the treatment of burns. Future research should develop systematic, valid measures in order to obtain an analytically and statistically adequate result.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

N/A systematic review does not need an ethics committee

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Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

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I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

All relevant data are within the manuscript and its Supporting Information files.

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