Available online 16 November 2022, 101810

Endoscopic Retrograde Cholangiopancreatography (ERCP), even in expert hands, may fail in 5–10% of cases, especially in cases of papillary infiltration, malignant gastric outlet obstruction, or surgically altered anatomy. Percutaneous transhepatic biliary drainage (PTBD) has represented the traditional rescue therapy, despite associated with high rate of adverse events, need for re-interventions and an inferior quality of life. The evolution of Endoscopic Ultrasound (EUS) from a diagnostic to a therapeutic tool offers an effective and safe alternative for internal biliary drainage (BD) into the stomach or the duodenum. EUS-BD is reported to have similar or even improved efficacy and increased safety when compared to PTBD and can be performed in the same session of a failed ERCP.

This review summarizes technical aspects of intra-hepatic and extra-hepatic EUS-BD (including hepatico-gastrostomy, choledocho-duodenostomy and rendezvous) together with current evidence and future perspectives that steadily cements EUS-BD's place in multidisciplinary management of bilio-pancreatic diseases.

Endoscopic retrograde cholangiopancreatography

Biliary drainage

Biliary obstruction

EUS-Guided biliary drainage

EUS-Guided choledocho-duodenostomy (EUS CDS)

EUS-Guided hepatico-gastrostomy (EUS-HGS)

EUS-Guided rendezvous (EUS RV)

EUS-Guided antegrade stenting (EUS AS)

© 2022 Published by Elsevier Ltd.