Ferreira D, Nordberg A, Westman E (2020) Biological subtypes of Alzheimer’s disease: a systematic review and meta-analysis. Neurology 94:436–448
Article PubMed PubMed Central Google Scholar
Graff-radford J, Yong KXX, Apostolova LG, Bouwman FH, Carrillo M, Dickerson BC et al (2021) New insights into atypical Alzheimer’s disease in the era of biomarkers. Lancet Neurol 20:222–234
Article PubMed PubMed Central Google Scholar
Habes M, Grothe MJ, Tunc B, Mcmillan C, Wolk DA, Davatzikos C (2020) Disentangling heterogeneity in Alzheimer’s disease and related dementias using data-driven methods. Biol Psychiatry 88:70–82
Article PubMed PubMed Central Google Scholar
Hanna Al-Shaikh FS, Duara R, Crook JE, Lesser ER, Schaeverbeke J, Hinkle KM et al (2020) Selective vulnerability of the nucleus basalis of meynert among neuropathologic subtypes of alzheimer disease. JAMA Neurol 77:225–233
Jellinger KA (2021) Pathobiological subtypes of alzheimer disease. Dement Geriatr Cogn Disord 49:321–333
Charil A, Shcherbinin S, Southekal S, Devous MD, Mintun M, Murray ME et al (2019) Tau subtypes of Alzheimer’s disease determined in vivo using flortaucipir PET imaging. J Alzheimer’s Dis 71:1037–1048
Murray ME, Graff-Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW (2011) Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 10:785–796
Article PubMed PubMed Central Google Scholar
Mohanty R, Mårtensson G, Poulakis K, Muehlboeck J-S, Rodriguez-Vieitez E, Chiotis K et al (2020) Comparison of subtyping methods for neuroimaging studies in Alzheimer’s disease: a call for harmonization. Brain Commun 2:192
Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML et al (2012) Neuroimaging correlates of pathologically defined subtypes of Alzheimer’s disease: a case-control study. Lancet Neurol 11:868–877
Article PubMed PubMed Central Google Scholar
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259
Article CAS PubMed Google Scholar
Whitwell JL, Graff-Radford J, Tosakulwong N, Weigand SD, Machulda M, Senjem ML et al (2018) [18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer’s disease. Ann Neurol 83:248–257
Article CAS PubMed PubMed Central Google Scholar
Young CB, Winer JR, Younes K, Cody KA, Betthauser TJ, Johnson SC et al (2022) Divergent cortical tau positron emission tomography patterns among patients with preclinical alzheimer disease. JAMA Neurol 79:592–603
Mueller SG, Weiner MW, Thal LJ, Petersen RC, Jack C, Jagust W et al (2005) The Alzheimer’s disease neuroimaging initiative. Neuroimaging Clin N Am 15:869–877
Article PubMed PubMed Central Google Scholar
Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS et al (2019) The bivariate distribution of amyloid-β and tau: Relationship with established neurocognitive clinical syndromes. Brain 142:3230–3242
Article PubMed PubMed Central Google Scholar
Byun MS, Kim SE, Park J, Yi D, Choe YM, Sohn BK et al (2015) Heterogeneity of regional brain atrophy patterns associated with distinct progression rates in Alzheimer’s disease. PLoS ONE 10:e0142756
Article PubMed PubMed Central Google Scholar
Jack CR, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS et al (2017) Defining imaging biomarker cut points for brain aging and Alzheimer’s disease. Alzheimer’s Dement 13:205–216
Tudorascu D, Ikonomovic MD, Burnham S, Minhas D, Pascoal TA, Mason NS et al (2021) What Is T+? A gordian knot of tracers, thresholds, and topographies. J Nucl Med 62:614–619
Schöll M, Lockhart SN, Schonhaut DR, Neil JPO, Ossenkoppele R, Baker SL et al (2016) PET imaging of tau deposition in the aging human brain Michael. Neuron 89:971–982
Article PubMed PubMed Central Google Scholar
Maass A, Landau S, Baker SL, Horng A, Lockhart SN, La R et al (2017) Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer’s disease. Neuroimage 157:448–463
Article CAS PubMed Google Scholar
Risacher SL, Anderson WH, Charil A, Castelluccio PF, Shcherbinin S, Saykin AJ et al (2017) Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline. Neurology 89:2176–2186
Article PubMed PubMed Central Google Scholar
Leuzy A, Chiotis K, Lemoine L, Gillberg PG, Almkvist O, Rodriguez-Vieitez E et al (2019) Tau PET imaging in neurodegenerative tauopathies—still a challenge. Mol Psychiatry 24:1112–1134
Article CAS PubMed PubMed Central Google Scholar
Vogel JW, Young AL, Oxtoby NP, Smith R, Ossenkoppele R, Strandberg OT et al (2021) Four distinct trajectories of tau deposition identified in Alzheimer’s disease. Nat Med 27:871–881
Article CAS PubMed PubMed Central Google Scholar
Muehlboeck J-S, Westman E, Simmons A (2014) TheHiveDB image data management and analysis framework. Front Neuroinform 7:49
Article PubMed PubMed Central Google Scholar
Sahoo A, Bejanin A, Murray ME, Tosakulwong N, Weigand SD, Serie AM et al (2018) TDP-43 and Alzheimer’s disease pathologic subtype in non-amnestic Alzheimer’s disease dementia. J Alzheimer’s Dis 64:1227–1233
Petersen C, Nolan AL, de Paula-França-Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML et al (2019) Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta Neuropathol 138:597–612
Article CAS PubMed PubMed Central Google Scholar
Uretsky M, Gibbons LE, Mukherjee S, Trittschuh EH, Fardo DW, Boyle PA et al (2021) Longitudinal cognitive performance of Alzheimer’s disease neuropathological subtypes. Alzheimer’s Dement Transl Res Clin Interv 7:1–13
Smirnov DS, Salmon DP, Galasko D, Goodwill VS, Hansen LA, Zhao Y et al (2022) Association of neurofibrillary tangle distribution with age at onset-related clinical heterogeneity in Alzheimer disease. Neurology 98:E506-517
Article CAS PubMed Google Scholar
Corder EH, Woodbury MA, Volkmann I, Madsen DK, Bogdanovic N, Winblad B (2000) Density profiles of Alzheimer disease regional brain pathology for the Huddinge brain bank: Pattern recognition emulates and expands upon Braak staging. Exp Gerontol 35:851–864
Article CAS PubMed Google Scholar
Schwarz AJ, Yu P, Miller BB, Shcherbinin S, Dickson J, Navitsky M et al (2016) Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages. Brain 139:1539–1550
Schwarz AJ, Shcherbinin S, Slieker LJ, Risacher SL, Charil A, Irizarry MC et al (2018) Topographic staging of tau positron emission tomography images. Alzheimer’s Dement Diagnosis Assess Dis Monit 10:221–231
Toledo JB, Liu H, Grothe MJ, Rashid T, Launer L et al (2022) Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer’s disease continuum. Alzheimer’s Dement 8:1–14
Palleis C, Brendel M, Finze A, Weidinger E, Bötzel K, Danek A et al (2021) Cortical [18F]PI-2620 binding differentiates corticobasal syndrome subtypes. Mov Disord 36:2104–2115
Article CAS PubMed Google Scholar
Rullmann M, Brendel M, Schroeter M, Saur D, Levin J, Perneczky R et al (2022) Multicenter F-18-PI-2620 PET for in vivo Braak staging of tau pathology in Alzheimer’s disease. Biomolecules 12:458
Article CAS PubMed PubMed Central Google Scholar
Krishnadas N, Huang K, Schultz SA, Doré V, Bourgeat P, Goh AMY et al (2022) Visually identified Tau 18F-MK6240 PET patterns in symptomatic Alzheimer’s disease. J Alzheimers Dis 88:1627–1637
Article CAS PubMed PubMed Central Google Scholar
Ferreira D (2020) A conceptual framework for future studies on subtypes of Alzheimer’s disease. Alzheimer’s Dement 16(Suppl.4): e037181. https://doi.org/10.1002/alz.037181
Franzmeier N, Dewenter A, Frontzkowski L, Dichgans M, Rubinski A, Neitzel J, et al (2020) Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease. Sci Adv 6:eabd1327
Moloney CM, Lowe VJ, Murray ME (2021) Visualization of neurofibrillary tangle maturity in Alzheimer’s disease: a clinicopathologic perspective for biomarker research. Alzheimer’s Dement 17:1554–1574
Braak H, Del Tredici K (2015) The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease. Brain 138:2814–2833
Westman E, Aguilar C, Muehlboeck JS, Simmons A (2013) Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer’s disease and mild cognitive impairment. Brain Topogr 26:9–23
留言 (0)