McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M et al (2022) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 24(1):4–131. https://doi.org/10.1002/ejhf.2333

Article  PubMed  Google Scholar 

Brunner-La Rocca HP, Linssen GC, Smeele FJ, van Drimmelen AA, Schaafsma HJ, Westendorp PH et al (2019) Contemporary drug treatment of chronic heart failure with reduced ejection fraction: the CHECK-HF Registry. JACC Heart Fail 7(1):13–21. https://doi.org/10.1016/j.jchf.2018.10.010

Article  PubMed  Google Scholar 

Täger T, Fröhlich H, Seiz M, Katus HA, Frankenstein L (2019) READY: relative efficacy of LDs in patients with chronic systolic heart failure-a systematic review and network meta-analysis of randomised trials. Heart Fail Rev 24(4):461–472. https://doi.org/10.1007/s10741-019-09771-8

Article  CAS  PubMed  Google Scholar 

Damman K, Kjekshus J, Wikstrand J, Cleland JG, Komajda M, Wedel H et al (2016) Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction. Eur J Heart Fail 18(3):328–336. https://doi.org/10.1002/ejhf.462 (Epub 2015 Dec 23)

Article  PubMed  Google Scholar 

Pellicori P, Cleland JG, Zhang J, Kallvikbacka-Bennett A, Urbinati A, Shah P et al (2016) Cardiac dysfunction, congestion and loop diuretics: their relationship to prognosis in heart failure. Cardiovasc Drugs Ther 30(6):599–609. https://doi.org/10.1007/s10557-016-6697-7

Article  CAS  PubMed  Google Scholar 

Martens P, Verbrugge FH, Nijst P, Dupont M, Mullens W (2017) Changes in loop diuretic dose and outcome after cardiac resynchronization therapy in patients with heart failure and reduced left ventricular ejection fractions. Am J Cardiol 120(2):267–273. https://doi.org/10.1016/j.amjcard.2017.04.021 (Epub 2017 Apr 27)

Article  CAS  PubMed  Google Scholar 

Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Crespo Leiro M, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Fabbri G, Urso R, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors AA, Nielsen OW, Zannad F, Tavazzi L, Heart Failure Association of the European Society of Cardiology (HFA) (2013) EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail 15(7):808–817. https://doi.org/10.1093/eurjhf/hft050 (Epub 2013 Mar 28)

Article  PubMed  Google Scholar 

Kapelios CJ, Kaldara E, Ntalianis A, Nana E, Pantsios C, Repasos E et al (2014) Lowering furosemide dose in stable chronic heart failure patients with reduced ejection fraction is not accompanied by decompensation: a randomized study. Int J Cardiol 177(2):690–692. https://doi.org/10.1016/j.ijcard.2014.09.156 (Epub 2014 Oct 8)

Article  PubMed  Google Scholar 

Mullens W, Damman K, Harjola VP, Mebazaa A, Brunner-La Rocca HP, Martens P et al (2019) The use of diuretics in heart failure with congestion—a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 21(2):137–155. https://doi.org/10.1002/ejhf.1369 (Epub 2019 Jan 1)

Article  PubMed  Google Scholar 

Cleland JGF, Pellicori P (2021) To master heart failure, first master congestion. Lancet 398(10304):935–936. https://doi.org/10.1016/S0140-6736(21)01914-0 (Epub 2021 Aug 27)

Article  PubMed  Google Scholar 

Merlo M, Cannatà A, Gobbo M, Stolfo D, Elliott PM, Sinagra G (2018) Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail 20(2):228–239. https://doi.org/10.1002/ejhf.1103 (Epub 2017 Dec 22)

Article  PubMed  Google Scholar 

Costanzo MR, Stevenson LW, Adamson PB, Desai AS, Heywood JT, Bourge RC et al (2016) Interventions linked to decreased heart failure hospitalizations during ambulatory pulmonary artery pressure monitoring. JACC Heart Fail 4(5):333–344. https://doi.org/10.1016/j.jchf.2015.11.011 (Epub 2016 Feb 10)

Article  PubMed  Google Scholar 

Rohde LE, Rover MM, Figueiredo Neto JA, Danzmann LC, Bertoldi EG, Simões MV et al (2019) Short-term diuretic withdrawal in stable outpatients with mild heart failure and no fluid retention receiving optimal therapy: a double-blind, multicentre, randomized trial. Eur Heart J 40(44):3605–3612. https://doi.org/10.1093/eurheartj/ehz554

Article  PubMed  Google Scholar 

Dauw J, Martens P, Tersalvi G, Schouteden J, Deferm S, Gruwez H, De Moor B et al (2021) Diuretic response and effects of diuretic omission in ambulatory heart failure patients on chronic low-dose loop diuretic therapy. Eur J Heart Fail 23(7):1110–1119. https://doi.org/10.1002/ejhf.2145

Article  CAS  PubMed  Google Scholar 

Sutton MG, Plappert T, Hilpisch KE, Abraham WT, Hayes DL, Chinchoy E (2006) Sustained reverse left ventricular structural remodelling with cardiac resynchronization at one year is a function of etiology: quantitative Doppler echocardiographic evidence from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). Circulation 113(2):266–272. https://doi.org/10.1161/CIRCULATIONAHA.104.520817 (Epub 2006 Jan 9)

Article  PubMed  Google Scholar 

Merlo M, Cannatà A, Pio Loco C, Stolfo D, Barbati G, Artico J et al (2020) Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy. Eur J Heart Fail 22(7):1111–1121. https://doi.org/10.1002/ejhf.1914 (Epub 2020 Jun 26)

Article  PubMed  Google Scholar 

Nuzzi V, Cannatà A, Manca P, Castrichini M, Barbati G, Aleksova A et al (2021) Atrial fibrillation in dilated cardiomyopathy: outcome prediction from an observational registry. Int J Cardiol 15(323):140–147. https://doi.org/10.1016/j.ijcard.2020.08.062 (Epub 2020 Aug 25)

Article  Google Scholar 

Pinto YM, Elliott PM, Arbustini E, Adler Y, Anastasakis A, Böhm M et al (2016) Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. Eur Heart J 37(23):1850–1858. https://doi.org/10.1093/eurheartj/ehv727 (Epub 2016 Jan 19)

Article  PubMed  Google Scholar 

Vargo DL, Kramer WG, Black PK, Smith WB, Serpas T, Brater DC (1995) Bioavailability, pharmacokinetics, and pharmacodynamics of torsemide and furosemide in patients with congestive heart failure. Clin Pharmacol Ther 57(6):601–609. https://doi.org/10.1016/0009-9236(95)90222-8

Article  CAS  PubMed  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28(1):1-39.e14. https://doi.org/10.1016/j.echo.2014.10.003

Article  PubMed  Google Scholar 

Cannatà A, Merlo M, Dal Ferro M, Barbati G, Manca P, Paldino A et al (2022) Association of titin variations with late-onset dilated cardiomyopathy. JAMA Cardiol. https://doi.org/10.1001/jamacardio.2021.5890 (Epub ahead of print)

Article  PubMed  Google Scholar 

Manca P, Cannatà A, Nuzzi V, Bromage DI, Varrà GG, Rossi M et al (2021) Prevalence and evolution of right ventricular dysfunction among different genetic backgrounds in dilated cardiomyopathy. Can J Cardiol 37(11):1743–1750. https://doi.org/10.1016/j.cjca.2021.06.024 (Epub 2021 Jul 14)

Article  PubMed  Google Scholar 

Manca P, Nuzzi V, Cannatà A, Merlo M, Sinagra G (2021) Contemporary etiology and prognosis of dilated non-ischemic cardiomyopathy published online ahead of print, 2021 Aug 2]. Minerva Cardiol Angiol. 10:10. https://doi.org/10.23736/S2724-5683.21.05736-7

Article  Google Scholar 

Pellicori P, Fitchett D, Kosiborod MN, Ofstad AP, Seman L, Zinman B et al (2021) Use of diuretics and outcomes in patients with type 2 diabetes: findings from the EMPA-REG OUTCOME trial. Eur J Heart Fail 23(7):1085–1093. https://doi.org/10.1002/ejhf.2220 (Epub 2021 Jun 28)

Article  PubMed  Google Scholar 

Cleland JG, Shelton R, Nikitin N, Ford S, Frison L, Grind M (2007) Prevalence of markers of heart failure in patients with atrial fibrillation and the effects of ximelagatran compared to warfarin on the incidence of morbid and fatal events: a report from the SPORTIF III and V trials. Eur J Heart Fail 9(6–7):730–739. https://doi.org/10.1016/j.ejheart.2007.01.013

Article  CAS  PubMed  Google Scholar 

Kapelios CJ, Laroche C, Crespo-Leiro MG, Anker SD, Coats AJS, Díaz-Molina B et al (2020) Association between LD dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry. Eur J Heart Fail 22(8):1424–1437. https://doi.org/10.1002/ejhf.1796 (Epub 2020 Apr 1)

Article  PubMed  Google Scholar 

Halliday BP, Wassall R, Lota AS, Khalique Z, Gregson J, Newsome S et al (2019) Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial. Lancet 393(10166):61–73. https://doi.org/10.1016/S0140-6736(18)32484-X (Epub 2018 Nov 11)

Article  PubMed  PubMed Central  Google Scholar 

Dal Ferro M, Stolfo D, Altinier A, Gigli M, Perrieri M, Ramani F et al (2017) Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy. Heart 103(21):1704–1710. https://doi.org/10.1136/heartjnl-2016-311017 (Epub 2017 Apr 17)

Article  CAS  Google Scholar 

Stelken AM, Younis LT, Jennison SH, Miller DD, Miller LW, Shaw LJ et al (1996) Prognostic value of cardiopulmonary exercise testing using percent achieved of predicted peak oxygen uptake for patients with ischemic and dilated cardiomyopathy. J Am Coll Cardiol 27(2):345–352. https://doi.org/10.1016/0735-1097(95)00464-5

Article  CAS  PubMed  Google Scholar 

Masci PG, Doulaptsis C, Bertella E, Del Torto A, Symons R, Pontone, et al (2014) Incremental prognostic value of myocardial fibrosis in patients with non-ischemic cardiomyopathy without congestive heart failure. Circ Heart Fail 7(3):448–456. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000996 (Epub 2014 Mar 19)

Article  PubMed  Google Scholar 

Pinamonti B, Di Lenarda A, Sinagra G, Camerini F (1993) Restrictive left ventricular filling pattern in dilated cardiomyopathy assessed by Doppler echocardiography: clinical, echocardiographic and hemodynamic correlations and prognostic implications. Heart Muscle Disease Study Group. J Am Coll Cardiol 22(3):808–815. https://doi.org/10.1016/0735-1097(93)90195-7

Article  CAS  PubMed  Google Scholar