Extraskeletal myxoid chondrosarcoma: p53 and Ki-67 offer prognostic value for clinical outcome — an immunohistochemical and molecular analysis of 31 cases

Stout AP, Verner EW (1953) Chondrosarcoma of the extraskeletal soft tissues. Cancer 6(3):581–590

Article  CAS  PubMed  Google Scholar 

Enzinger FM, Shiraki M (1972) Extraskeletal myxoid chondrosarcoma An analysis of 34 cases. Hum Pathol 3(3):421–35

Article  CAS  PubMed  Google Scholar 

Horvai AE, Agaram NP, Lucas DR (2020) Extraskeletal myxoid chondrosarcoma. In: WHO Classification of Tumours Editorial Board(ed) WHO Classification of tumours of soft tissue and bone, 5th edn. IARC Press, Lyon, 303–305.

Saleh G, Evans HL, Ro JY, Ayala AG (1992) Extraskeletal myxoid chondrosarcoma. A clinicopathologic study of ten patients with long-term follow-up. Cancer 70(12):2827–30

Article  CAS  PubMed  Google Scholar 

Xu B, Chang K, Folpe AL, Kao YC, Wey SL, Huang HY et al (2020) Head and neck mesenchymal neoplasms with GLI1 gene alterations: a pathologic entity with distinct histologic features and potential for distant metastasis. Am J Surg Pathol 44(6):729–737

Article  PubMed  PubMed Central  Google Scholar 

Goh YW, Spagnolo DV, Platten M, Caterina P, Fisher C, Oliveira AM et al (2001) Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation. Histopathology 39(5):514–524

Article  CAS  PubMed  Google Scholar 

Aigner T, Oliveira AM, Nascimento AG (2004) Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype. Mod Pathol 17(2):214–221

Article  PubMed  Google Scholar 

Oliveira AM, Sebo TJ, McGrory JE, Gaffey TA, Rock MG, Nascimento AG (2000) Extraskeletal myxoid chondrosarcoma: a clinicopathologic, immunohistochemical, and ploidy analysis of 23 cases. Mod Pathol 13(8):900–908

Article  CAS  PubMed  Google Scholar 

Yoshida A, Makise N, Wakai S, Kawai A, Hiraoka N (2018) INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. Mod Pathol 31(5):744–752

Article  CAS  PubMed  Google Scholar 

Okamoto S, Hisaoka M, Ishida T, Imamura T, Kanda H, Shimajiri S et al (2001) Extraskeletal myxoid chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 18 cases. Hum Pathol 32(10):1116–1124

Article  CAS  PubMed  Google Scholar 

Hinrichs SH, Jaramillo MA, Gumerlock PH, Gardner MB, Lewis JP, Freeman AE (1985) Myxoid chondrosarcoma with a translocation involving chromosomes 9 and 22. Cancer Genet Cytogenet 14(3–4):219–226

Article  CAS  PubMed  Google Scholar 

Gill S, McManus AP, Crew AJ, Benjamin H, Sheer D, Gusterson BA et al (1995) Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma. Genes Chromosomes Cancer 12(4):307–310

Article  CAS  PubMed  Google Scholar 

Labelle Y, Zucman J, Stenman G, Kindblom LG, Knight J, Turc-Carel C et al (1995) Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. Hum Mol Genet 4(12):2219–2226

Article  CAS  PubMed  Google Scholar 

Clark J, Benjamin H, Gill S, Sidhar S, Goodwin G, Crew J et al (1996) Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene 12(2):229–235

CAS  PubMed  Google Scholar 

Panagopoulos I, Mencinger M, Dietrich CU, Bjerkehagen B, Saeter G, Mertens F et al (1999) Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). Oncogene 18(52):7594–7598

Article  CAS  PubMed  Google Scholar 

Hisaoka M, Ishida T, Imamura T, Hashimoto H (2004) TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. Genes Chromosomes Cancer 40(4):325–328

Article  CAS  PubMed  Google Scholar 

Sjögren H, Wedell B, Meis-Kindblom JM, Kindblom LG, Stenman G (2000) Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). Cancer Res 60(24):6832–6835

PubMed  Google Scholar 

Broehm CJ, Wu J, Gullapalli RR, Bocklage T (2014) Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. Cancer Genet 207(6):276–80

Article  CAS  PubMed  Google Scholar 

Urbini M, Astolfi A, Pantaleo MA, Serravalle S, Dei Tos AP, Picci P et al (2017) HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. Genes Chromosomes Cancer 56(7):582–586

Article  CAS  PubMed  Google Scholar 

Benini S, Cocchi S, Gamberi G, Magagnoli G, Vogel D, Ghinelli C et al (2014) Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. J Mol Diagn 16(3):314–323

Article  CAS  PubMed  Google Scholar 

Antonescu CR, Argani P, Erlandson RA, Healey JH, Ladanyi M, Huvos AG (1998) Skeletal and extraskeletal myxoid chondrosarcoma: a comparative clinicopathologic, ultrastructural, and molecular study. Cancer 83(8):1504–1521

Article  CAS  PubMed  Google Scholar 

Agaram NP, Zhang L, Sung YS, Singer S, Antonescu CR (2014) Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. Hum Pathol 45(5):1084–1091

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flucke U, Tops BB, Verdijk MA, van Cleef PJ, van Zwam PH, Slootweg PJ et al (2012) NR4A3 rearrangement reliably distinguishes between the clinicopathologically overlapping entities myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma. Virchows Arch 460(6):621–628

Article  PubMed  PubMed Central  Google Scholar 

Vargas AC, Maclean FM, Bonar F, Mahar A, Gill AJ (2019) NR4A3 immunohistochemistry lacks sensitivity for the diagnosis of extraskeletal myxoid chondrosarcoma. Am J Surg Pathol 43(12):1726–1728

Article  PubMed  Google Scholar 

Meis-Kindblom JM, Bergh P, Guntenberg B, Kindblom LG (1999) Extraskeletal myxoid chondrosarcoma: a reappraisal of its morphologic spectrum and prognostic factors based on 117 cases. Am J Surg Pathol 23:636–650

Article  CAS  PubMed  Google Scholar 

Kawaguchi S, Wada T, Nagoya S, Ikeda T, Isu K, Yamashiro K et al (2003) Extraskeletal myxoid chondrosarcoma: a multi-institutional study of 42 cases in Japan. Cancer 97:1285–1292

Article  PubMed  Google Scholar 

Oshiro Y, Shiratsuchi H, Tamiya S, Oda Y, Toyoshima S, Tsuneyoshi M (2000) Extraskeletal myxoid chondrosarcoma with rhabdoid features, with special reference to its aggressive behavior. Int J Surg Pathol 8(2):145–152

Article  PubMed  Google Scholar 

Brown JM, Rakoczy K, Pretell-Mazzini J (2022) Extraskeletal myxoid chondrosarcoma: clinical features and overall survival. Cancer Treat Res Commun 31:100530

Article  PubMed  Google Scholar 

Kaplan E, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481

Article  Google Scholar 

Peto R, Peto P (1987) Asymptomatically efficient rank invariant test procedures. J Roy Stat Soc 135:185–206

Article  Google Scholar 

Drilon AD, Bhuchar PS, G, D’Adamo DR, Keohan ML, Fisher C, et al (2008) Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy. Cancer 113:3364–3371

Article  PubMed  Google Scholar 

Wang C, You ZJ, Chen XY, Lin J, Wu YJ (2022) Mutation of KIT in cellular extraskeletal myxoid chondrosarcoma: a case report and literature review. Diagn Pathol 17(1):42

Article  PubMed  PubMed Central  Google Scholar 

Hornick JL, Fletcher CD (2002) Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution. Am J Clin Pathol 117:188–193

Article  PubMed  Google Scholar 

Subramanian S, West RB, Marinelli RJ, Nielsen TO, Rubin BP, Goldblum JR et al (2005) The gene expression profile of extraskeletal myxoid chondrosarcoma. J Pathol 206(4):433–444

Article  CAS  PubMed  Google Scholar 

Stacchiotti S, Pantaleo MA, Astolfi A, Dagrada GP, Negri T, Dei Tos AP et al (2014) Activity of sunitinib in extraskeletal myxoid chondrosarcoma. Eur J Cancer 50(9):1657–1664

Article  CAS  PubMed  Google Scholar 

Jiang T, Wang G, Liu Y, Feng L, Wang M, Liu J et al (2021) Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers. Acta Pharm Sin B 11(2):355–372

Article  CAS  PubMed  Google Scholar 

Brčić I, Godschachner TM, Bergovec M, Igrec J, Till H, Lackner H et al (2021) Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions. Mod Pathol 34(2):396–407

Article  PubMed  Google Scholar 

Britanova O, Akopov S, Lukyanov S, Gruss P, Tarabykin V (2005) Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Eur J Neurosci 21(3):658–668

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