Pilot-phase PET/CT study targeting integrin αvβ6 in pancreatic cancer patients using the cystine-knot peptide–based 18F-FP-R01-MG-F2

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.

Article  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA: Cancer J Clin. 2021;71:7–33. https://doi.org/10.3322/caac.21654.

Article  Google Scholar 

Allen PJ, Kuk D, Castillo CF, Basturk O, Wolfgang CL, Cameron JL, et al. Multi-institutional validation study of the American Joint Commission on Cancer (8th edition) changes for T and N staging in patients with pancreatic adenocarcinoma. Ann Surg. 2017;265:185–91. https://doi.org/10.1097/sla.0000000000001763.

Article  PubMed  Google Scholar 

Breuss J, Gallo J, DeLisser H, Klimanskaya I, Folkesson H, Pittet J, et al. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci. 1995;108:2241–51.

Article  CAS  PubMed  Google Scholar 

Sipos B, Hahn D, Carceller A, Piulats J, Hedderich J, Kalthoff H, et al. Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro. Histopathology. 2004;45:226–36. https://doi.org/10.1111/j.1365-2559.2004.01919.x.

Article  CAS  PubMed  Google Scholar 

Maubant S, Cruet-Hennequart S, Dutoit S, Denoux Y, Crouet H, Henry-Amar M, et al. Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens. J Mol Histol. 2005;36:119–29. https://doi.org/10.1007/s10735-004-4273-0.

Article  CAS  PubMed  Google Scholar 

Orimoto AM, Neto CF, Pimentel ER, Sanches JA, Sotto MN, Akaishi E, et al. High numbers of human skin cancers express MMP2 and several integrin genes. J Cutan Pathol. 2008;35:285–91.

Article  PubMed  Google Scholar 

Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Investig. 2005;115:339–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elayadi AN, Samli KN, Prudkin L, Liu YH, Bian A, Xie XJ, et al. A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer. Cancer Res. 2007;67:5889–95. https://doi.org/10.1158/0008-5472.Can-07-0245.

Article  CAS  PubMed  Google Scholar 

Hazelbag S, Kenter GG, Gorter A, Dreef EJ, Koopman LA, Violette SM, et al. Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. J Pathol. 2007;212:316–24. https://doi.org/10.1002/path.2168.

Article  CAS  PubMed  Google Scholar 

Zhang ZY, Xu KS, Wang JS, Yang GY, Wang W, Wang JY, et al. Integrin alphanvbeta6 acts as a prognostic indicator in gastric carcinoma. Clin Oncol (R Coll Radiol). 2008;20:61–6. https://doi.org/10.1016/j.clon.2007.09.008.

Article  Google Scholar 

Kimura RH, Wang L, Shen B, Huo L, Tummers W, Filipp FV, et al. Evaluation of integrin alphavbeta6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis. Nat Commun. 2019;10:4673. https://doi.org/10.1038/s41467-019-11863-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023–7.

PubMed  Google Scholar 

Nordhausen K, Oja H. Multivariate L1 methods: the package MNM. J Stat Softw. 2011;43:1–28.

Article  Google Scholar 

Yeh R, Dercle L, Garg I, Wang ZJ, Hough DM, Goenka AH. The role of 18F-FDG PET/CT and PET/MRI in pancreatic ductal adenocarcinoma. Abdom Radiol (NY). 2018;43:415–34. https://doi.org/10.1007/s00261-017-1374-2.

Article  Google Scholar 

Niu J, Li Z. The roles of integrin αvβ6 in cancer. Cancer Lett. 2017;403:128–37. https://doi.org/10.1016/j.canlet.2017.06.012.

Article  CAS  PubMed  Google Scholar 

Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: structure, function and role in health and disease. Int J Biochem Cell Biol. 2018;99:186–96. https://doi.org/10.1016/j.biocel.2018.04.013.

Article  CAS  PubMed  Google Scholar 

Färber SF, Wurzer A, Reichart F, Beck R, Kessler H, Wester HJ, et al. Therapeutic radiopharmaceuticals targeting integrin αvβ6. ACS Omega. 2018;3:2428–36. https://doi.org/10.1021/acsomega.8b00035.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hausner SH, Bauer N, Hu LY, Knight LM, Sutcliffe JL. The effect of bi-terminal PEGylation of an integrin αvβ6-targeted 18F peptide on pharmacokinetics and tumor uptake. J Nucl Med. 2015;56:784–90. https://doi.org/10.2967/jnumed.114.150680.

Article  CAS  PubMed  Google Scholar 

Nothelfer EM, Zitzmann-Kolbe S, Garcia-Boy R, Krämer S, Herold-Mende C, Altmann A, et al. Identification and characterization of a peptide with affinity to head and neck cancer. J Nucl Med. 2009;50:426–34. https://doi.org/10.2967/jnumed.108.058123.

Article  CAS  PubMed  Google Scholar 

Kraft S, Diefenbach B, Mehta R, Jonczyk A, Luckenbach GA, Goodman SL. Definition of an unexpected ligand recognition motif for alphav beta6 integrin. J Biol Chem. 1999;274:1979–85. https://doi.org/10.1074/jbc.274.4.1979.

Article  CAS  PubMed  Google Scholar 

Altmann A, Sauter M, Roesch S, Mier W, Warta R, Debus J, et al. Identification of a novel ITGalphavbeta6-binding peptide using protein separation and phage display. Clin Cancer Res. 2017;23:4170–80. https://doi.org/10.1158/1078-0432.CCR-16-3217.

Article  CAS  PubMed  Google Scholar 

Flechsig P, Lindner T, Loktev A, Roesch S, Mier W, Sauter M, et al. PET/CT Imaging of NSCLC with a alphavbeta6 integrin-targeting peptide. Mol Imaging Biol. 2019;21:973–83. https://doi.org/10.1007/s11307-018-1296-6.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif