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aDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
bShanghai Fourth People’s Hospital affiliated to Tongji University, Shanghai, China
cAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
dAnhui Mental Health Center, Hefei, China
eThe College of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
fCollaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
gInstitute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China
hDepartment of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
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Article / Publication DetailsFirst-Page Preview
Received: April 08, 2022
Accepted: August 14, 2022
Published online: November 16, 2022
Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 3
ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)
For additional information: https://www.karger.com/NPS
AbstractIntroduction: Somatic symptoms often occur as a manifestation of depression and anxiety. The subgenual anterior cingulate cortex (sgACC) has been shown to be closely related to both depression and anxiety and plays an important role in somatic symptoms. However, little is known regarding whether the abnormal function of the sgACC contributes to the common somatic symptoms of depression and anxiety. Methods: Resting-state functional connectivity (RSFC) analysis based on the seed of the sgACC was investigated in 23 major depressive disorder (MDD) patients with somatic symptoms, 20 generalized anxiety disorder (GAD) patients with somatic symptoms, and 22 demographically matched healthy controls (HCs). The severity of depression, anxiety, and somatic symptoms was assessed using the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and the 15-item somatic symptom severity scale from the Patient Health Questionnaire (PHQ-15), respectively. An analysis of covariance analysis (ANCOVA) was conducted to determine RSFC alterations among GAD, MDD, and HC groups with age, gender, and head motion as covariates. Correlation analyses were conducted between the RSFC of the sgACC and PHQ-15. Results: The significantly different RSFC of right sgACC among the three groups was found in right STG, left cerebellum, and right postcentral. Post hoc analysis indicated that both MDD and GAD patients showed a decreased RSFC between the right sgACC and right STG than HCs, and both were negatively correlated with the PHQ-15 scores. Conclusion: The abnormally decreased RSFC of the sgACC and STG may be the underlying common mechanisms of depression and anxiety combined with somatic symptoms.
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Received: April 08, 2022
Accepted: August 14, 2022
Published online: November 16, 2022
Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 3
ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)
For additional information: https://www.karger.com/NPS
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