Impact of alcohol exposure on neural development and network formation in human cortical organoids

Roozen S, Peters G-JY, Kok G, Townend D, Nijhuis J, Curfs L. Worldwide prevalence of fetal alcohol spectrum disorders: a systematic literature review including meta-analysis. Alcohol Clin Exp Res. 2016;40:18–32.

PubMed  Google Scholar 

Lange S, Probst C, Rehm J, Popova S. Prevalence of binge drinking during pregnancy by country and World Health Organization region: systematic review and meta-analysis. Reprod Toxicol. 2017;73:214–21.

CAS  PubMed  Google Scholar 

Popova S, Lange S, Probst C, Gmel G, Rehm J. Global prevalence of alcohol use and binge drinking during pregnancy, and fetal alcohol spectrum disorder. Biochem Cell Biol. 2018;96:237–40.

CAS  PubMed  Google Scholar 

May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D, et al. Prevalence of fetal alcohol spectrum disorders in 4 US communities. JAMA. 2018;319:474–82.

PubMed  PubMed Central  Google Scholar 

May PA, Gossage JP, Kalberg WO, Robinson LK, Buckley D, Manning M, et al. Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev Disabil Res Rev. 2009;15:176–92.

PubMed  Google Scholar 

Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 1973;302:999–1001.

CAS  PubMed  Google Scholar 

Burd L, Klug MG, Bueling R, Martsolf J, Olson M, Kerbeshian J. Mortality rates in subjects with fetal alcohol spectrum disorders and their siblings. Birth Defects Res Part A - Clin Mol Teratol. 2008;82:217–23.

CAS  Google Scholar 

Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais A, et al. Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders. Pediatrics. 2016;138:e20154256.

Rasmussen C, Andrew G, Zwaigenbaum L, Tough S. Neurobehavioural outcomes of children with fetal alcohol spectrum disorders: a Canadian perspective. Paediatr Child Health (Oxf). 2008;13:185–91.

Google Scholar 

De Filippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP, et al. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016;9:1–15.

Sánchez-Alvarez R, Gayen S, Vadigepalli R, Anni H. Ethanol diverts early neuronal differentiation trajectory of embryonic stem cells by disrupting the balance of lineage specifiers. PLoS One. 2013;8:e63794.

PubMed  PubMed Central  Google Scholar 

Veazey KJ, Carnahan MN, Muller D, Miranda RC, Golding MC. Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation. Alcohol Clin Exp Res. 2013;37:1111–22.

CAS  PubMed  PubMed Central  Google Scholar 

Valenzuela CF, Puglia MP, Zucca S. Focus on: Neurotransmitter systems. Alcohol Res Heal. 2011;34:106–20.

Google Scholar 

Halder D, Mandal C, Lee BH, Lee JS, Choi MR, Chai JC, et al. PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol. Hum Exp Toxicol. 2015;34:1017–27.

CAS  PubMed  Google Scholar 

Guizzetti M, Moore NH, Giordano G, VanDeMark KL, Costa LG. Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia. 2010;58:1395–406.

PubMed  PubMed Central  Google Scholar 

Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, et al. Alcohol metabolism contributes to brain histone acetylation. Nature. 2019;574:717–21.

CAS  PubMed  PubMed Central  Google Scholar 

Zhao X, Bhattacharyya A. Human models are needed for studying human neurodevelopmental disorders. Am J Hum Genet. 2018;103:829–57.

CAS  PubMed  PubMed Central  Google Scholar 

Arzua T, Yan Y, Jiang C, Logan S, Allison RL, Wells C, et al. Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids. Transl Psychiatry. 2020;10:1–21.

Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci. 2015;112:201520760.

Google Scholar 

Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, et al. Guided self-organization and cortical plate formation in human brain organoids. Nat Biotechnol. 2017;35:659–66.

CAS  PubMed  PubMed Central  Google Scholar 

Lancaster MA, Renner M, Martin C-A, Wenzel D, Bicknell LS, Hurles ME, et al. Cerebral organoids model human brain development and microcephaly. Nature. 2013;501:373–9.

CAS  PubMed  Google Scholar 

Luo C, Lancaster MA, Castanon R, Nery JR, Knoblich JA, Ecker JR. Cerebral organoids recapitulate epigenomic signatures of the human fetal brain. Cell Rep. 2016;17:3369–84.

CAS  PubMed  PubMed Central  Google Scholar 

Trujillo CA, Gao R, Negraes PD, Gu J, Buchanan J, Preissl S, et al. Complex oscillatory waves emerging from cortical organoids model early human brain network development. Cell Stem Cell. 2019;25:558–69.e7.

CAS  PubMed  PubMed Central  Google Scholar 

Pașca AM, Park J-Y, Shin H-W, Qi Q, Revah O, Krasnoff R, et al. Human 3D cellular model of hypoxic brain injury of prematurity. Nat Med. 2019;25:784–91.

PubMed  PubMed Central  Google Scholar 

Adams JW, Cugola FR, Muotri AR. Brain organoids as tools for modeling human neurodevelopmental disorders. Physiology. 2019;34:365–75.

CAS  PubMed  PubMed Central  Google Scholar 

Trujillo CA, Adams JW, Negraes PD, Carromeu C, Tejwani L, Acab A, et al. Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids. EMBO Mol Med. 2021;13:e12523.

CAS  PubMed  Google Scholar 

Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Yang SM, Berger DR, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545:48–53.

CAS  PubMed  PubMed Central  Google Scholar 

Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, et al. Altered neuronal network and rescue in a human MECP2 duplication model. Mol Psychiatry. 2016;21:178–88.

CAS  PubMed  Google Scholar 

Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, et al. A human neurodevelopmental model for Williams syndrome. Nature. 2016;536:338–43.

CAS  PubMed  PubMed Central  Google Scholar 

Negraes PD, Trujillo CA, Yu N-K, Wu W, Yao H, Liang N, et al. Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy. Mol Psychiatry. 2021;26:7047–68.

PubMed  PubMed Central  Google Scholar 

Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9:R137.1–9.

Google Scholar 

Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38:576–89.

CAS  PubMed  PubMed Central  Google Scholar 

Garcia BA, Mollah S, Ueberheide BM, Busby SA, Muratore TL, Shabanowitz J, et al. Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nat Protoc. 2007;2:933–8.

CAS  PubMed  PubMed Central  Google Scholar 

MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B, et al. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics. 2010;26:966–8.

CAS  PubMed  PubMed Central  Google Scholar 

Merritt CR, Ong GT, Church SE, Barker K, Danaher P, Geiss G, et al. Multiplex digital spatial profiling of proteins and RNA in fixed tissue. Nat Biotechnol. 2020;38:586–99.

CAS  PubMed  Google Scholar 

Vangipuram SD, Grever WE, Parker GC, Lyman WD. Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression. Alcohol Clin Exp Res. 2008;32:339–47.

CAS  PubMed  Google Scholar 

Dolganiuc A, Szado G. In vitro and in vivo models of acute alcohol exposure. World J Gastroenterol. 2009;15:1168–77.

PubMed  PubMed Central  Google Scholar 

Tateno M, Ukai W, Yamamoto M, Hashimoto E, Ikeda H, Saito T. The effect of ethanol on cell fate determination of neural stem cells. Alcohol Clin Exp Res. 2005;29:225–9.

Google Scholar 

Burd L, Blair J, Dropps K. Prenatal alcohol exposure, blood alcohol concentrations and alcohol elimination rates for the mother, fetus and newborn. J Perinatol. 2012;32:652–9.

CAS  PubMed  Google Scholar 

Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, et al. Spatio-temporal transcriptome of the human brain. Nature. 2011;478:483–9.

CAS  PubMed  PubMed Central  Google Scholar 

Bershteyn M, Nowakowski T, Pollen A, DiLullo E, Nene A, Wynshaw-Boris A, et al. Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia. Cell Stem Cell. 2017;20:435–449.e4.

CAS  PubMed  PubMed Central  Google Scholar 

Trevino AE, Sinnott-Armstrong N, Andersen J, Yoon S-J, Huber N, Pritchard JK, et al. Chromatin accessibility dynamics in a model of human forebrain development. Science. 2020;367:eaay1645.

Kouzarides T. Chromatin modifications and their function. Cell. 2007;128:693–705.

CAS  PubMed  Google Scholar 

Vaglenova J, Pandiella N, Wijayawardhane N, Vaithianathan T, Birru S, Breese C, et al. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008;33:1071–83.

CAS  PubMed  Google Scholar 

Wijayawardhane N, Shonesy BC, Vaglenova J, Vaithianathan T, Carpenter M, Breese CR, et al. Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission. Neurobiol Dis. 2007;26:696–706.

CAS  PubMed  Google Scholar 

Wijayawardhane N, Shonesy BC, Vaithianathan T, Pandiella N, Vaglenova J, Breese CR, et al. Ameliorating effects of preadolescent aniracetam treatment on prenatal ethanol-induced impairment in AMPA receptor activity. Neurobiol Dis. 2008;29:81–91.

CAS  PubMed 

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