Letter by Sherratt Regarding Article, “Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy”

"Letter by Sherratt Regarding Article, “Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy”." Circulation, 146(20), pp. e282–e283

Footnotes1. Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif J-C, et al. Effects of randomized treatment with icosapent ethyl and a mineral oil comparator on interleukin-1β, interleukin-6, C-reactive protein, oxidized low-density lipoprotein cholesterol, homocysteine, lipoprotein(a), and lipoprotein-associated phospholipase A2: a REDUCE-IT biomarker substudy.Circulation. 2022; 146:372–379. doi: 10.1161/CIRCULATIONAHA.122.059410LinkGoogle Scholar2. Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT, Juliano RA, Jiao L, Granowitz C, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia.N Engl J Med. 2019; 380:11–22. doi: 10.1056/NEJMoa1812792CrossrefMedlineGoogle Scholar3. Ridker PM, Danielson E, Fonseca FAH, Genest J, Gotto AM, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.N Engl J Med. 2008; 359:2195–2207. doi: 10.1056/NEJMoa0807646CrossrefMedlineGoogle Scholar4. Ridker PM, Everett BM, Pradhan A, MacFadyen JG, Solomon DH, Zaharris E, Mam V, Hasan A, Rosenberg Y, Iturriaga E, et al. Low-dose methotrexate for the prevention of atherosclerotic Events.N Engl J Med. 2018; 380:752–762. doi: 10.1056/NEJMoa1809798CrossrefMedlineGoogle Scholar5. Olshansky B, Chung MK, Budoff MJ, Philip S, Jiao L, Doyle RT, Copland C, Giaquinto A, Juliano RA, et al. Mineral oil: safety and use as placebo in REDUCE-IT and other clinical studies.Eur Heart J Suppl. 2020; 22:J34–j48. doi: 10.1093/eurheartj/suaa117CrossrefMedlineGoogle Scholar

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