Predicting viral load suppression by self-reported adherence, pharmacy refill counts and real time medication monitoring among people living with HIV in Tanzania

Ianniello LUS. Neutron sources. Science. 1995;268(5209):350–350.

Article  CAS  Google Scholar 

Arnsten JH, Demas PA, Grant RW, Gourevitch MN, Farzadegan H, Howard AA, et al. Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV-infected drug users. J Gen Intern Med. 2002;17(5):377–81.

Article  PubMed  PubMed Central  Google Scholar 

Hine P, Smith R, Eshun-Wilson I, Orrell C, Cohen K, Leeflang MMG, et al. Measures of antiretroviral adherence for detecting viral non-suppression in people living with HIV. Cochrane Database Syst Rev. 2018. https://doi.org/10.1002/14651858.CD013080.

Article  PubMed  PubMed Central  Google Scholar 

UNAIDS. Data 2020. Program HIV/AIDS [Internet]. 2020;1–436. Available from: http://www.unaids.org/sites/default/files/media_asset/20170720_Data_book_2017_en.pdf.

Bijker R, Jiamsakul A, Kityo C, Kiertiburanakul S, Siwale M, Phanuphak P, et al. Adherence to antiretroviral therapy for HIV in sub-Saharan Africa and Asia: a comparative analysis of two regional cohorts. J Int AIDS Soc. 2017;20(1):1–10.

Article  Google Scholar 

Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21–30.

Article  CAS  PubMed  Google Scholar 

Adeniyi OV, Ajayi AI, Ter Goon D, Owolabi EO, Eboh A, Lambert J. Factors affecting adherence to antiretroviral therapy among pregnant women in the Eastern Cape. South Africa BMC Infect Dis. 2018;18(1):1–11.

Google Scholar 

Kaleva V. Adherence to medication. Pediatriya. 2015;55(2):68–9.

Google Scholar 

Kabore L, Muntner P, Chamot E, Zinski A, Burkholder G, Mugavero MJ. Self-report measures in the assessment of antiretroviral medication adherence: comparison with medication possession ratio and HIV viral load. J Int Assoc Provid AIDS Care. 2015;14(2):156–62.

Article  PubMed  Google Scholar 

Craker L, Tarantino N, Whiteley L, Brown L. Measuring antiretroviral adherence among young people living with HIV: observations from a real-time monitoring device versus self-report. AIDS Behav. 2019;23(8):2138–45. https://doi.org/10.1007/s10461-019-02448-1.

Article  PubMed  PubMed Central  Google Scholar 

Shi L, Liu J, Koleva Y, Fonseca V, Kalsekar A, Pawaskar M. Concordance of adherence measurement using self-reported adherence questionnaires and medication monitoring devices. Pharmacoeconomics. 2010;28(12):1097–107. https://doi.org/10.2165/11537400-000000000-00000.

Article  PubMed  Google Scholar 

Evans C, Turner K, Suggs LS, Occa A, Juma A, Blake H. Developing a mHealth intervention to promote uptake of HIV testing among African communities in the conditions: A qualitative study. BMC Public Health. 2016;16(1):1–16. https://doi.org/10.1186/s12889-016-3278-4.

Article  Google Scholar 

Patel AR, Kessler J, Braithwaite RS, Nucifora KA, Thirumurthy H, Zhou Q, et al. Economic evaluation of mobile phone text message interventions to improve adherence to HIV therapy in Kenya. Medicine. 2017;96(7):1–9.

Article  Google Scholar 

Shah R, Watson J, Free C. A systematic review and meta-analysis in the effectiveness of mobile phone interventions used to improve adherence to antiretroviral therapy in HIV infection. BMC Public Health. 2019;19(1):915.

Article  PubMed  PubMed Central  Google Scholar 

Ngowi KM, Lyamuya F, Mmbaga BT, Muro E, Hillu Z, Shirima M, et al. Technical and psychosocial challenges of mhealth usage for antiretroviral therapy adherence among people living with HIV in a resource-limited setting: case series. JMIR Form Res. 2020;4(6):e14649.

Article  PubMed  PubMed Central  Google Scholar 

Kamal S, Rosen MI, Lazar C, Siqueiros L, Wang Y, Daar ES, et al. Perceptions of people living with HIV and HIV healthcare providers on real-time measuring and monitoring of antiretroviral adherence using ingestible sensors: a qualitative study. AIDS Res Treat. 2020;2020:1098109.

PubMed  PubMed Central  Google Scholar 

DiCarlo LA. Role for direct electronic verification of pharmaceutical ingestion in pharmaceutical development. Contemp Clin Trials. 2012;33(4):593–600. https://doi.org/10.1016/j.cct.2012.03.008.

Article  PubMed  Google Scholar 

Levine AJ, Hinkin CH, Marion S, Keuning A, Castellon SA, Lam MM, et al. Adherence to antiretroviral medications in HIV: differences in data collected via self-report and electronic monitoring. Heal Psychol Off J Div Heal Psychol Am Psychol Assoc. 2006;25(3):329–35.

Google Scholar 

Mutevedzi PC, Lessells RJ, Rodger AJ, Newell ML. Association of age with mortality and virological and immunological response to antiretroviral therapy in rural south african adults. PLoS ONE. 2011;6(7):1–8.

Article  Google Scholar 

Musiimenta A, Atukunda EC, Tumuhimbise W, Pisarski EE, Tam M, Wyatt MA, et al. Acceptability and feasibility of real-time antiretroviral therapy adherence interventions in rural Uganda: Mixed-method pilot randomized controlled trial. J Med Internet Res. 2018;20(5):1–21.

Google Scholar 

Pearson CR, Simoni JM, Hoff P, Kurth AE, Martin DP. Assessing antiretroviral adherence via electronic drug monitoring and self-report: an examination of key methodological issues. AIDS Behav. 2007;2:161–73.

Article  Google Scholar 

Been SK, Yildiz E, Nieuwkerk PT, Pogány K, van de Vijver DAMC, Verbon A. Self-reported adherence and pharmacy refill adherence are both predictive for an undetectable viral load among HIV-infected migrants receiving cART. PLoS ONE. 2017;12(11):e0186912.

Article  PubMed  PubMed Central  Google Scholar 

Sangeda RZ, Mosha F, Prosperi M, Aboud S, Vercauteren J, Camacho RJ, et al. Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings. BMC Public Health. 2014;14(1):1035. https://doi.org/10.1186/1471-2458-14-1035.

Article  PubMed  PubMed Central  Google Scholar 

Martelli G, Antonucci R, Mukurasi A, Zepherine H, Nöstlinger C. Adherence to antiretroviral treatment among children and adolescents in Tanzania: comparison between pill count and viral load outcomes in a rural context of Mwanza region. PLoS ONE. 2019;14(3):e0214014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sumari-de Boer IM, Ngowi KM, Sonda TB, Pima FM, Masika L V., Sprangers MAG, et al. Effect of Digital Adherence Tools on Adherence to Antiretroviral Treatment Among Adults Living With HIV in Kilimanjaro, Tanzania: A Randomized Controlled Trial. J Acquir Immune Defic Syndr. 2021;87(5):1136–44.

Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81. https://doi.org/10.1016/j.jbi.2008.08.010.

Article  PubMed  Google Scholar 

NBS. The United Republic of Tanzania. Development. 2019;7(5,371,780,231.09):2,274,923,575.00–29.08.

De Boer IM, Prins JM, Sprangers MAG, Nieuwkerk PT. Using different calculations of pharmacy refill adherence to predict virological failure among HIV-infected patients. J Acquir Immune Defic Syndr. 2010;55(5):635–40.

Article  PubMed  Google Scholar 

Ministry of health. community development, gender, elderly a, children t National guidelines for the management of HIV and AIDS. World Popul Policies. 2019;2020:266–7.

Google Scholar 

Scott AJ, Hosmer DW, Lemeshow S. Applied logistic regression. Biometrics. 1991;47(4):1632.

Article  Google Scholar 

Been SK, Yildiz E, Nieuwkerk PT, Pogány K, Van De Vijver DAMC, Verbon A. Self-reported adherence and pharmacy refill adherence are both predictive for an undetectable viral load among HIV-infected migrants receiving cART. PLoS ONE. 2017;12(11):1–12.

Article  Google Scholar 

Sangeda RZ, Mosha F, Prosperi M, Aboud S, Vercauteren J, Camacho RJ, et al. Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings. BMC Public Health. 2014;14(1):1–11.

Article  Google Scholar 

Al-Hassany L, Kloosterboer SM, Dierckx B, Koch BCP. Assessing methods of measuring medication adherence in chronically ill children–a narrative review. Patient Prefer Adherence. 2019;13:1175–89.

Article  PubMed  PubMed Central  Google Scholar 

Stirratt MJ, Dunbar-Jacob J, Crane HM, Simoni JM, Czajkowski S, Hilliard ME, et al. Self-report measures of medication adherence behavior: recommendations on optimal use. Transl Behav Med. 2015;4:470–82.

Article  Google Scholar 

Mekuria LA, Prins JM, Yalew AW, Sprangers MAG, Nieuwkerk PT. Which adherence measure—self-report, clinician recorded or pharmacy refill—is best able to predict detectable viral load in a public ART programme without routine plasma viral load monitoring? Trop Med Int Heal. 2016;21(7):856–69.

Article  Google Scholar 

Genn L, Chapman J, Okatch H, Abell N, Marukutira T, Tshume O, Anabwani G, LE Gross R. Pharmacy refill data are poor predictors of virologic treatment outcomes in adolescents with HIV in Botswana. Physiol Behav. 2018;176(5):139–48.

Google Scholar 

Genn L, Chapman J, Okatch H, Abell N, Marukutira T, Tshume O, et al. Pharmacy refill data are poor predictors of virologic treatment outcomes in adolescents with HIV in botswana. AIDS Behav. 2019;23(8):2130–7.

Article  PubMed  PubMed Central  Google Scholar 

Orrell C, Cohen K, Leisegang R, Bangsberg DR, Wood R, Maartens G. Comparison of six methods to estimate adherence in an ART-naïve cohort in a resource-poor setting: Which best predicts virological and resistance outcomes? AIDS Res Ther. 2017;14(1):1–11.

Article  Google Scholar 

Phillips AN, Cambiano V, Nakagawa F, Bansi-Matharu L, Sow PS, Ehrenkranz P, et al. Cost effectiveness of potential ART adherence monitoring interventions in Sub-Saharan Africa. PLoS ONE. 2016;11(12):e0167654.

Article  PubMed  PubMed Central  Google Scholar 

Abdu M, Walelgn B. Determinant factors for adherence to antiretroviral therapy among adult HIV patients at dessie referral hospital, South Wollo, Northeast Ethiopia: a case–control study. AIDS Res Ther. 2021;18(1):39. https://doi.org/10.1186/s12981-021-00365-9.

Article  PubMed  PubMed Central  Google Scholar 

Sangeda RZ, Mosha F, Aboud S, Kamuhabwa A, Chalamilla G, Vercauteren J, et al. Predictors of non adherence to antiretroviral therapy at an urban HIV care and treatment center in Tanzania. Drug Healthc Patient Saf. 2018;10:79–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ngowi KM, Masika L, Lyamuya F, Muro E, Mmbaga BT, Sprangers MAG, et al. Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring. AIDS Res Ther. 2020;17(1):57. https://doi.org/10.1186/s12981-020-00313-z.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Q, Li X, Qiao S, Shen Z, Zhou Y. Comparing self-reported medication adherence measures with hair antiretroviral concentration among people living with HIV in Guangxi, China. AIDS Res Ther. 2020;17(1):8.

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