Trigeminal Neuralgia

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition.

Cephalalgia. 38: 1-211Haviv Y. Khan J. Zini A. et al.

Trigeminal neuralgia (part I): Revisiting the clinical phenotype.

Cephalalgia. 36: 730-746

Trigeminal neuralgia: A symptomatic study of 126 successive patients with and without previous interventions.

Pain Clinic. 12: 93-101Maarbjerg S. Gozalov A. Olesen J. et al.

Trigeminal neuralgia--a prospective systematic study of clinical characteristics in 158 patients.

Headache. 54: 1574-1582https://doi.org/10.1111/head.12441

The changing face of trigeminal neuralgia—A narrative review.

Headache: The J Head Face Pain. 61: 817-837Maarbjerg S. Gozalov A. Olesen J. et al.

Concomitant persistent pain in classical trigeminal neuralgia--evidence for different subtypes.

Headache. 54: 1173-1183https://doi.org/10.1111/head.12384Kuncz A. Vörös E. Barzó P. et al.

Comparison of clinical symptoms and magnetic resonance angiographic (MRA) results in patients with trigeminal neuralgia and persistent idiopathic facial pain. Medium-term outcome after microvascular decompression of cases with positive MRA findings.

Cephalalgia. 26: 266-276

Bilateral trigeminal neuralgia: a therapeutic dilemma.

Br J Neurosurg. 14: 33-39Katusic S. Beard C.M. Bergstralh E. et al.

Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945-1984.

Ann Neurol. 27: 89-95Tan C.Y. Shahrizaila N. Goh K.J.

Clinical Characteristics, Pain, and Quality of Life Experiences of Trigeminal Neuralgia in a Multi-Ethnic Asian Cohort.

J Oral Facial Pain Headache. 31: e15-e20https://doi.org/10.11607/ofph.1793Benoliel R. Zadik Y. Eliav E. et al.

Peripheral painful traumatic trigeminal neuropathy: clinical features in 91 cases and proposal of novel diagnostic criteria.

J Orofac Pain. 26: 49-58Siqueira S.R. Teixeira M.J. Siqueira J.T.

Clinical characteristics of patients with trigeminal neuralgia referred to neurosurgery.

Eur J Dent. 3: 207-212

Facial pain. II. A prospective survey of 1052 patients with a view of: character of the attacks, onset, course, and character of pain.

Acta Neurochir (Wien). 107: 121-128

The mechanism of the pain in trigeminal neuralgia.

J Neurol Neurosurg Psychiatr. 22: 36-43Younis S. Maarbjerg S. Reimer M. et al.

Quantitative sensory testing in classical trigeminal neuralgia-a blinded study in patients with and without concomitant persistent pain.

Pain. 157: 1407-1414Maier C. Baron R. Tölle T.R. et al.

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes.

Pain. 150: 439-450

Facial pain. IV. A prospective study of 1052 patients with a view of: precipitating factors, associated symptoms, objective psychiatric and neurological symptoms.

Acta Neurochir (Wien). 108: 100-109

The importance of autonomic symptoms in trigeminal neuralgia. Clinical article.

J Neurosurg. 115: 210-216Maarbjerg S. di Stefano G. Bendtsen L. et al.

Trigeminal neuralgia – diagnosis and treatment.

Cephalalgia. 37: 648-657

Trigeminal neuralgia with lacrimation or SUNCT syndrome?.

Cephalalgia. 18: 85-90Benoliel R. Sharav Y. Haviv Y. et al.

Tic, Triggering, and Tearing: From CTN to SUNHA.

Headache. 57: 997-1009Chen Q. Yi D.I. Perez J.N.J. et al.

The Molecular Basis and Pathophysiology of Trigeminal Neuralgia.

Int J Mol Sci. 23: 3604Gambeta E. Chichorro J.G. Zamponi G.W.

Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments.

Mol Pain. 16 ()https://doi.org/10.1177/1744806920901890Liu M. Zhong J. Xia L. et al.

The expression of voltage-gated sodium channels in trigeminal nerve following chronic constriction injury in rats.

Int J Neurosci. 129: 955-962Siqueira S.R.D.T. Alves B. Malpartida H.M.G. et al.

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

Neuroscience. 164: 573-577Xu W. Zhang J. Wang Y. et al.

Changes in the expression of voltage-gated sodium channels Nav1.3, Nav1.7, Nav1.8, and Nav1.9 in rat trigeminal ganglia following chronic constriction injury.

NeuroReport. 27: 929-934Devor M. Amir R. Rappaport Z.H.

Pathophysiology of Trigeminal Neuralgia: The Ignition Hypothesis.

Clin J Pain. 18: 4-13

Abnormal impulse generation in focally demyelinated trigeminal roots.

J Neurosurg. 53: 674-683Calvin W.H. Loeser J.D. Howe J.F.

A neurophysiological theory for the pain mechanism of tic douloureux.

Pain. 3: 147-154

Electrophysiological responses of trigeminal root ganglion neurons in vitro.

Neuroscience. 24: 635-646

Trigeminal neuralgia: The role of self-sustaining discharge in the trigeminal ganglion.

Pain. 56: 127-138

Trigeminal neuralgia: pathology and pathogenesis.

Brain. 124: 2347-2360

Ectopic generation of impulses and cross-talk in spinal nerve roots of ?dystrophic? mice.

Ann Neurol. 3: 351-357

Functional cross-excitation between afferent A- and C-neurons in dorsal root ganglia.

Neuroscience. 95: 189-195Rappaport Z.H. Govrin-Lippmann R. Devor M.

An electron-microscopic analysis of biopsy samples of the trigeminal root taken during microvascular decompressive surgery.

Stereotact Funct Neurosurg. 68: 182-186Lutz J. Thon N. Stahl R. et al.

Microstructural alterations in trigeminal neuralgia determined by diffusion tensor imaging are independent of symptom duration, severity, and type of neurovascular conflict.

J Neurosurg. 124: 823-830Obermann M. Yoon M.S. Ese D. et al.

Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia.

Neurology. 69: 835-841Peker S. Kurtkaya Ö. Üzün İ. et al.

Microanatomy of the Central Myelin-Peripheral Myelin Transition Zone of the Trigeminal Nerve.

Neurosurgery. 59: 354-359Zhang C. Hu H. Das S. et al.

Structural and Functional Brain Abnormalities in Trigeminal Neuralgia: A Systematic Review.

J Oral Facial Pain Headache. 34: 222-235Tang Y. Wang M. Zheng T. et al.

Grey matter volume alterations in trigeminal neuralgia: A systematic review and meta-analysis of voxel-based morphometry studies.

Prog Neuro-Psychopharmacology Biol Psychiatry. 98: 109821

Trigeminal neuralgia: Pathology and pathogenesis.

Brain. 124: 2347-2360Nurmikko T.J. Eldridge P.R.

Trigeminal neuralgia--pathophysiology, diagnosis and current treatment.

Br J Anaesth. 87: 117-132Maarbjerg S. Wolfram F. Gozalov A. et al.

Association between neurovascular contact and clinical characteristics in classical trigeminal neuralgia: A prospective clinical study using 3.0 Tesla MRI.

Cephalalgia. 35: 1077-1084Antonini G. di Pasquale A. Cruccu G. et al.

Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: a blinded case-control study and meta-analysis.

Pain. 155: 1464-1471

Trigeminal Neuralgia: New Evidence for Origins and Surgical Treatment.

Neurosurgery. 63: 52-55Di Stefano G. Maarbjerg S. Truini A.

Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options.

J Headache Pain. 20: 20Osterberg A. Boivie J. Thuomas K.A.

Central pain in multiple sclerosis--prevalence and clinical characteristics.

Eur J Pain. 9: 531-542Foley P.L. Vesterinen H.M. Laird B.J. et al.

Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.

Pain. 154: 632-642Danesh-Sani S.A. Rahimdoost A. Soltani M. et al.

Clinical assessment of orofacial manifestations in 500 patients with multiple sclerosis.

J Oral Maxillofac Surg. 71: 290-294de Simone R. Marano E. Brescia Morra V. et al.

A clinical comparison of trigeminal neuralgic pain in patients with and without underlying multiple sclerosis.

Neurol Sci. 26: s150-s151Ferraro D. Annovazzi P. Moccia M. et al.

Characteristics and treatment of Multiple Sclerosis-related trigeminal neuralgia: An Italian multi-centre study.

Mult Scler Relat Disord. 37: 101461Antonaci F. Arceri S. Rakusa M. et al.

Pitfals in recognition and management of trigeminal neuralgia.

J Headache Pain. 21: 82van Vliet J.A. Eekers P.J.E. Haan J. et al.Dutch RUSSH Study Group

Features involved in the diagnostic delay of cluster headache.

J Neurol Neurosurg Psychiatry. 74: 1123-1125Cruccu G. Gronseth G. Alksne J. et al.

AAN-EFNS guidelines on trigeminal neuralgia management.

Eur J Neurol. 15: 1013-1028Gronseth G. Cruccu G. Alksne J. et al.

Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies.

Neurology. 71: 1183-1190

A four year double-blind study of tegretol(r)in facial pain.

Headache: The J Head Face Pain. 9: 54-57

Carbamazepine in the Treatment of Neuralgia.

Arch Neurol. 19: 129Campbell F.G. Graham J.G. Zilkha K.J.

Clinical trial of carbazepine (tegretol) in trigeminal neuralgia.

J Neurol Neurosurg Psychiatry. 29: 265-267

Trigeminal Neuralgia - A Debilitating Facial Pain.

Rev Pain. 5: 26-34Wiffen P. Collins S. McQuay H. et al.

Anticonvulsant drugs for acute and chronic pain.

Cochrane Database Syst Rev. 3: CD001133Wiffen P.J. McQuay H.J. Moore R.A.

Carbamazepine for acute and chronic pain.

Cochrane Database Syst Rev. 3: CD005451Besi E. Boniface D.R. Cregg R. et al.

Comparison of tolerability and adverse symptoms in oxcarbazepine and carbamazepine in the treatment of trigeminal neuralgia and neuralgiform headaches using the Liverpool Adverse Events Profile (AEP).

J Headache Pain. 16: 563Zakrzewska J.M. Patsalos P.N.

Oxcarbazepine: a new drug in the management of intractable trigeminal neuralgia.

J Neurol Neurosurg Psychiatry. 52: 472-476Fromm G.H. Terrence C.F. Chattha A.S. et al.

Baclofen in trigeminal neuralgia: its effect on the spinal trigeminal nucleus: a pilot study.

Arch Neurol. 37: 768-771Fromm G.H. Terrence C.F. Chattha A.S.

Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up.

Ann Neurol. 15: 240-244Zakrzewska J.M. Chaudhry Z. Nurmikko T.J. et al.

Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial.

Pain. 73: 223-230Lunardi G. Leandri M. Albano C. et al.

Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia.

Neurology. 48: 1714-1717

Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients.

Neurology. 51: 611-614Lechin F. van der Dijs B. Lechin M.E. et al.

Pimozide therapy for trigeminal neuralgia.

Arch Neurol. 46: 960-963Vilming S.T. Lyberg T. Lataste X.

Tizanidine in the Management of Trigeminal Neuralgia.

Cephalalgia. 6: 181-182Wu C.J. Lian Y.J. Zheng Y.K. et al.

Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial.

Cephalalgia. 32: 443-450Piovesan E.J. Teive H.G. Kowacs P.A. et al.

An open study of botulinum-A toxin treatment of trigeminal neuralgia.

Neurology. 65: 1306-1308Bohluli B. Motamedi M.H.K. Bagheri S.C. et al.

Use of botulinum toxin A for drug-refractory trigeminal neuralgia: preliminary report.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 111: 47-50Zúñiga C. Díaz S. Piedimonte F. et al.

Beneficial effects of botulinum toxin type A in trigeminal neuralgia.

Arq Neuropsiquiatr. 66: 500-503Türk U. Ilhan S. Alp R. et al.

Botulinum toxin and intractable trigeminal neuralgia.

Clin Neuropharmacol. 28: 161-162https://doi.org/10.1097/01.wnf.0000172497.24770.b0Borodic G.E. Acquadro M.A.

The use of botulinum toxin for the treatment of chronic facial pain.

J Pain. 3: 21-27Obermann M. Yoon M.S. Sensen K. et al.

Efficacy of pregabalin in the treatment of trigeminal neuralgia.

Cephalalgia. 28: 174-181Domingues R.B. Kuster G.W. Aquino C.C.H.

Treatment of trigeminal neuralgia with low doses of topiramate.

Arq Neuropsiquiatr. 65: 792-794

Topiramate versus carbamazepine for the treatment of classical trigeminal neuralgia: a meta-analysis.

CNS Drugs. 25: 847-857Jorns T.P. Johnston A. Zakrzewska J.M.

Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia.

Eur J Neurol. 16: 740-744Mitsikostas D.D. Pantes G v Avramidis T.G. et al.

An observational trial to investigate the efficacy and tolerability of levetiracetam in trigeminal neuralgia.

Headache. 50: 1371-1377Kotecha M. Cheshire W.P. Finnigan H. et al.

Design of Phase 3 Studies Evaluating Vixotrigine for Treatment of Trigeminal Neuralgia.

J Pain Res. 13: 1601-1609Zakrzewska J.M. Palmer J. Morisset V. et al.

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.

Lancet Neurol. 16: 291-300

Percutaneous retrogasserian glycerol rhizotomy. Current technique and results.

Neurosurg Clin N Am. 8: 63-74Bendtsen L. Zakrzewska J.M. Abbott J. et al.

European Academy of Neurology guideline on trigeminal neuralgia.

Eur J Neurol. 26: 831-849Seo H.J. Park C.K. Choi M.K. et al.

Clinical Outcome of Percutaneous Trigeminal Nerve Block in Elderly Patients in Outpatient Clinics.

J Korean Neurosurg Soc. 63: 814-820

Peripheral and gasserian ganglion-level procedures for the treatment of trigeminal neuralgia.

Clin J Pain. 18: 28-34Tatli M. Satici O. Kanpolat Y. et al.

Various surgical modalities for trigeminal neuralgia: literature study of respective long-term outcomes.

Acta Neurochir (Wien). 150: 243-255Burchiel K.J. Clarke H. Haglund M. et al.

Long-term efficacy of microvascular decompression in trigeminal neuralgia.

J Neurosurg. 69: 35-38Kalkanis S.N. Eskandar E.N. Carter B.S. et al.

Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumes.

Neurosurgery. 52 (): 1251-1261Barker F.G. Jannetta P.J. Bissonette D.J. et al.

The Long-Term Outcome of Microvascular Decompression for Trigeminal Neuralgia.

New Engl J Med. 334: 1077-1084Jawahar A. Wadhwa R. Berk C. et al.

Assessment of pain control, quality of life, and predictors of success after gamma knife surgery for the treatment of trigeminal neuralgia.

Neurosurg Focus. 18: E8Loescher A.R. Radatz M. Kemeny A. et al.

Stereotactic radiosurgery for trigeminal neuralgia: outcomes and complications.

Br J Neurosurg. 26: 45-52Tuleasca C. Carron R. Resseguier N. et al.

Patterns of pain-free response in 497 cases of classic trigeminal neuralgia treated with Gamma Knife surgery and followed up for least 1 year.

J Neurosurg. 117: 181-188

Comparison of posterior fossa exploration and stereotactic radiosurgery in patients with previously nonsurgically treated idiopathic trigeminal neuralgia.

Neurosurg Focus. 18: E6Sanchez-Mejia R.O. Limbo M. Cheng J.S. et al.

Recurrent or refractory trigeminal neuralgia after microvascular decompression, radiofrequency ablation, or radiosurgery.

Neurosurg Focus. 18: e12

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