Andersen C, Gronnemose AL, Pedersen JN, Nowak JS, Christiansen G, Nielsen J, Mulder FAA, Otzen DE, Jorgensen TJD (2021) Lipid peroxidation products HNE and ONE promote and stabilize alpha-synuclein oligomers by chemical modifications. Biochemistry 60:3644–3658. https://doi.org/10.1021/acs.biochem.1c00478
Article CAS PubMed Google Scholar
Arai Y, Yamazaki M, Mori O, Muramatsu H, Asano G, Katayama Y (2001) Alpha-synuclein-positive structures in cases with sporadic Alzheimer’s disease: morphology and its relationship to tau aggregation. Brain Res 888:287–296
Article CAS PubMed Google Scholar
Balasubramanian K, Schroit AJ (2003) Aminophospholipid asymmetry: A matter of life and death. Annu Rev Physiol 65:701–734. https://doi.org/10.1146/annurev.physiol.65.092101.142459
Article CAS PubMed Google Scholar
Bazinet RP, Laye S (2014) Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 15:771–785. https://doi.org/10.1038/nrn3820
Article CAS PubMed Google Scholar
Bell R, Vendruscolo M (2021) Modulation of the Interactions Between alpha-Synuclein and Lipid Membranes by Post-translational Modifications. Front Neurol 12:661117. https://doi.org/10.3389/fneur.2021.661117
Article PubMed PubMed Central Google Scholar
Cai Y, Lendel C, Osterlund L, Kasrayan A, Lannfelt L, Ingelsson M, Nikolajeff F, Karlsson M, Bergstrom J (2015) Changes in secondary structure of alpha-synuclein during oligomerization induced by reactive aldehydes. Biochem Biophys Res Commun 464:336–341. https://doi.org/10.1016/j.bbrc.2015.06.154
Article CAS PubMed Google Scholar
Castegna A, Lauderback CM, Mohmmad-Abdul H, Butterfield DA (2004) Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer’s disease. Brain Res 1004:193–197. https://doi.org/10.1016/j.brainres.2004.01.036
Article CAS PubMed Google Scholar
Castro-Perez JM, Kamphorst J, DeGroot J, Lafeber F, Goshawk J, Yu K, Shockcor JP, Vreeken RJ, Hankemeier T (2010) Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. J Proteome Res 9:2377–2389. https://doi.org/10.1021/pr901094j
Article CAS PubMed Google Scholar
Chen CT, Green JT, Orr SK, Bazinet RP (2008) Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostaglandins Leukot Essent Fatty Acids 79:85–91. https://doi.org/10.1016/j.plefa.2008.09.003
Article CAS PubMed Google Scholar
Chen Q, Chen Y, Zhang Y, Wang F, Yu H, Zhang C, Jiang Z, Luo W (2019) Iron deposition in Parkinson’s disease by quantitative susceptibility mapping. BMC Neurosci 20:23. https://doi.org/10.1186/s12868-019-0505-9
Article PubMed PubMed Central Google Scholar
Cole NB, Murphy DD, Grider T, Rueter S, Brasaemle D, Nussbaum RL (2002) Lipid droplet binding and oligomerization properties of the Parkinson’s disease protein alpha-synuclein. J Biol Chem 277:6344–6352. https://doi.org/10.1074/jbc.M108414200
Article CAS PubMed Google Scholar
Dasari AKR, Dillard L, Yi S, Viverette E, Hojjatian A, Sengupta U, Kayed R, Taylor KA, Borgnia MJ, Lim KH (2022) Untwisted alpha-synuclein filaments formed in the presence of lipid vesicles. Biochemistry 61:1766–1773. https://doi.org/10.1021/acs.biochem.2c00283
Article CAS PubMed Google Scholar
Davidson WS, Jonas A, Clayton DF, George JM (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem 273:9443–9449
Article CAS PubMed Google Scholar
De Franceschi G, Fecchio C, Sharon R, Schapira AHV, Proukakis C, Bellotti V, de Laureto PP (2017) alpha-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection. J Biol Chem 292:6927–6937. https://doi.org/10.1074/jbc.M116.765149
Article PubMed PubMed Central Google Scholar
Dei R, Takeda A, Niwa H, Li M, Nakagomi Y, Watanabe M, Inagaki T, Washimi Y, Yasuda Y, Horie K et al (2002) Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer’s disease. Acta Neuropathol 104:113–122. https://doi.org/10.1007/s00401-002-0523-y
Article CAS PubMed Google Scholar
Dexter DT, Carter CJ, Wells FR, Javoy-Agid F, Agid Y, Lees A, Jenner P, Marsden CD (1989) Basal lipid peroxidation in substantia nigra is increased in Parkinson’s disease. J Neurochem 52:381–389. https://doi.org/10.1111/j.1471-4159.1989.tb09133.x
Article CAS PubMed Google Scholar
Dexter DT, Wells FR, Lees AJ, Agid F, Agid Y, Jenner P, Marsden CD (1989) Increased Nigral iron content and alterations in other metal ions occurring in brain in Parkinson’s disease. J Neurochem 52:1830–1836. https://doi.org/10.1111/j.1471-4159.1989.tb07264.x
Article CAS PubMed Google Scholar
Dou T, Kurouski D (2022) Phosphatidylcholine and phosphatidylserine uniquely modify the secondary structure of alpha-synuclein oligomers formed in their presence at the early stages of protein aggregation. ACS Chem Neurosci 13:2380–2385. https://doi.org/10.1021/acschemneuro.2c00355
Article CAS PubMed Google Scholar
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T et al (2019) Lipidomic analysis of alpha-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for parkinson treatment. Mol Cell 73(1001–1014):e1008. https://doi.org/10.1016/j.molcel.2018.11.028
Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 24:6715–6723. https://doi.org/10.1523/JNEUROSCI.1594-04.2004
Article CAS PubMed PubMed Central Google Scholar
Gai WP, Power JH, Blumbergs PC, Blessing WW (1998) Multiple-system atrophy: a new alpha-synuclein disease? Lancet 352:547–548
Article CAS PubMed Google Scholar
Gilmozzi V, Gentile G, Castelo Rueda MP, Hicks AA, Pramstaller PP, Zanon A, Levesque M, Pichler I (2020) Interaction of alpha-synuclein with lipids: mitochondrial cardiolipin as a critical player in the pathogenesis of parkinson’s disease. Front Neurosci 14:578993. https://doi.org/10.3389/fnins.2020.578993
Article PubMed PubMed Central Google Scholar
Haider L, Fischer MT, Frischer JM, Bauer J, Hoftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, Lassmann H (2011) Oxidative damage in multiple sclerosis lesions. Brain 134:1914–1924. https://doi.org/10.1093/brain/awr128
Article PubMed PubMed Central Google Scholar
Hattingen E, Magerkurth J, Pilatus U, Mozer A, Seifried C, Steinmetz H, Zanella F, Hilker R (2009) Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson’s disease. Brain 132:3285–3297. https://doi.org/10.1093/brain/awp293
Jo E, McLaurin J, Yip CM, St George-Hyslop P, Fraser PE (2000) alpha-Synuclein membrane interactions and lipid specificity. J Biol Chem 275:34328–34334. https://doi.org/10.1074/jbc.M004345200
Article CAS PubMed Google Scholar
Kagan VE, Borisenko GG, Serinkan BF, Tyurina YY, Tyurin VA, Jiang J, Liu SX, Shvedova AA, Fabisiak JP, Uthaisang W et al (2003) Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine. Am J Physiol Lung Cell Mol Physiol 285:L1-17. https://doi.org/10.1152/ajplung.00365.2002
Article CAS PubMed Google Scholar
Leng Y, Chase TN, Bennett MC (2001) Muscarinic receptor stimulation induces translocation of an alpha-synuclein oligomer from plasma membrane to a light vesicle fraction in cytoplasm. J Biol Chem 276:28212–28218. https://doi.org/10.1074/jbc.M011121200
Article CAS PubMed Google Scholar
Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O’Connell B, Pollen DA, St George-Hyslop P et al (1998) Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer’s disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 153:1365–1370
Article CAS PubMed PubMed Central Google Scholar
Mahoney-Sanchez L, Bouchaoui H, Boussaad I, Jonneaux A, Timmerman K, Berdeaux O, Ayton S, Kruger R, Duce JA, Devos D et al (2022) Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition. Cell Rep 40:111231. https://doi.org/10.1016/j.celrep.2022.111231
Article CAS PubMed Google Scholar
Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D (2008) Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res 49:1137–1146. https://doi.org/10.1194/jlr.D700041-JLR200
Article CAS PubMed PubMed Central Google Scholar
Murphy KE, Cottle L, Gysbers AM, Cooper AA, Halliday GM (2013) ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies. Acta Neuropathol Commun 1:11. https://doi.org/10.1186/2051-5960-1-11
Article PubMed PubMed Central Google Scholar
Musteikyte G, Jayaram AK, Xu CK, Vendruscolo M, Krainer G, Knowles TPJ (2021) Interactions of alpha-synuclein oligomers with lipid membranes. Biochim Biophys Acta Biomembr 1863:183536. https://doi.org/10.1016/j.bbamem.2020.183536
Article CAS PubMed Google Scholar
Nasstrom T, Fagerqvist T, Barbu M, Karlsson M, Nikolajeff F, Kasrayan A, Ekberg M, Lannfelt L, Ingelsson M, Bergstrom J (2011) The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of alpha-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med 50:428–437. https://doi.org/10.1016/j.freeradbiomed.2010.11.027
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