CORRELATION BETWEEN AGE-RELATED CHANGES IN SKIN MORPHOLOGY AND TROPHIC FUNCTION OF THE TRIGEMINAL NERVE

Abstract

Huge advancements in the field of cosmetology and numerous methods of skin restoration have kept the studies of skin aging continually relevant and up-to-date. Age-related changes in the physiological parameters of skin cover might be related to a trophic innervation disorder, which, in its turn, is caused by aging manifesting itself in the corresponding structures of the vegetative nervous system. The present article aims at describing this particular skin aging mechanism. Reduction of the amount of cells in n. sensorius superior of the trigeminal nerve has been proven to be connected with a decrease in the amount of cells in the innervated areas of skin. This process may be considered one of the mechanisms of aging realized as a systemic phenomenon.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This study did not receive any funding

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Ethics committee of Rostov State Medical University gave ethical approval for this work

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Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

All data produced in the present work are contained in the manuscript

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