Agger SA, Lopez-Gallego F, Hoye TR, Schmidt-Dannert C (2008) Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120. J Bacteriol 190(18):6084–6096. https://doi.org/10.1128/JB.00759-08

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bentley FK, García-Cerdán JG, Chen H-C, Melis A (2013) Paradigm of monoterpene (β-phellandrene) hydrocarbons production via photosynthesis in Cyanobacteria. Bioenergy Res 6(3):917–929. https://doi.org/10.1007/s12155-013-9325-4

Article  CAS  Google Scholar 

Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK (2016) Overcoming heterologous protein interdependency to optimize P450-mediated taxol precursor synthesis in Escherichia coli. Proc Natl Acad Sci 113(12):3209–3214. https://doi.org/10.1073/pnas.1515826113

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang MCY, Keasling JD (2006) Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol 2(12):674–681. https://doi.org/10.1038/nchembio836

Article  CAS  PubMed  Google Scholar 

Chang W-c, Song H, Liu H-w, Liu P (2013) Current development in isoprenoid precursor biosynthesis and regulation. Curr Opin Chem Biol 17(4):571–579. https://doi.org/10.1016/j.cbpa.2013.06.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Jiang X, Xu M, Zhang M, Huang R, Huang J, Qi F (2019) Co-production of farnesol and coenzyme Q10 from metabolically engineered Rhodobacter sphaeroides. Microb Cell Fact 18(1):98. https://doi.org/10.1186/s12934-019-1145-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng T, Zhao G, Xian M, Xie C (2020) Improved cis-Abienol production through increasing precursor supply in Escherichia coli. Sci Rep 10(1):16791. https://doi.org/10.1038/s41598-020-73934-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conrado RJ, Varner JD, DeLisa MP (2008) Engineering the spatial organization of metabolic enzymes: mimicking nature’s synergy. Curr Opin Biotechnol 19(5):492–499. https://doi.org/10.1016/j.copbio.2008.07.006

Article  CAS  PubMed  Google Scholar 

Corey EJ, Roberts BE, Dixon BR (1995) Enantioselective total synthesis of beta-elemene and fuscol based on enantiocontrolled Ireland-Claisen rearrangement. J Am Chem Soc 117(1):193–196. https://doi.org/10.1021/ja00106a023

Article  CAS  Google Scholar 

Dai ZJ, Tang W, Lu WF, Gao J, Kang HF, Ma XB, Min WL, Wang XJ, Wu WY (2013) Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell Int 13(1):27. https://doi.org/10.1186/1475-2867-13-27

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Kraker JW, Franssen MC, de Groot A, Konig WA, Bouwmeester HJ (1998) (+)-Germacrene A biosynthesis. The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory. Plant physiol 117(4):1381–1392. https://doi.org/10.1104/pp.117.4.1381

Article  PubMed  PubMed Central  Google Scholar 

Deng Y, Sun M, Xu S, Zhou J (2016) Enhanced (S)-linalool production by fusion expression of farnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae. J Appl Microbiol 121(1):187–195. https://doi.org/10.1111/jam.13105

Article  CAS  PubMed  Google Scholar 

Edwards RA, Keller LH, Schifferli DM (1998) Improved allelic exchange vectors and their use to analyze 987P fimbria gene expression. Gene 207(2):149–157. https://doi.org/10.1016/s0378-1119(97)00619-7

Article  CAS  PubMed  Google Scholar 

Fu N, Quan L, Guo Y, Shi J (1984) Antitumor effect and pharmacological actions of beta-elemene isolated from the rhizome of Curcuma aromatica. Zhong Yao Tong Bao 9(02):83–87

CAS  PubMed  Google Scholar 

Gao X, Gao F, Liu D, Zhang H, Nie X, Yang C (2016) Engineering the methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2. Energy Environ Sci 9(4):1400–1411. https://doi.org/10.1039/c5ee03102h

Article  CAS  Google Scholar 

Garcia-Asua G, Cogdell RJ, Hunter CN (2002) Functional assembly of the foreign carotenoid lycopene into the photosynthetic apparatus of Rhodobacter sphaeroides, achieved by replacement of the native 3-step phytoene desaturase with its 4-step counterpart from Erwinia herbicola. Mol Microbiol 44(1):233–244. https://doi.org/10.1046/j.1365-2958.2002.02871.x

Article  CAS  PubMed  Google Scholar 

Guo Y, Wu X, Chen Y (1983) Isolation and identification of elemene from the essential oil of Curcuma wenyujin. Zhong Yao Tong Bao 8(03):31

CAS  PubMed  Google Scholar 

Hong J, Park SH, Kim S, Kim SW, Hahn JS (2019) Efficient production of lycopene in Saccharomyces cerevisiae by enzyme engineering and increasing membrane flexibility and NAPDH production. Appl Microbiol Biotechnol 103(1):211–223. https://doi.org/10.1007/s00253-018-9449-8

Article  CAS  PubMed  Google Scholar 

Hu Y, Zhou YJ, Bao J, Huang L, Nielsen J, Krivoruchko A (2017) Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene. J Ind Microbiol Biotechnol 44(7):1065–1072. https://doi.org/10.1007/s10295-017-1934-z

Article  CAS  PubMed  Google Scholar 

Julliard JH, Douce R (1991) Biosynthesis of the thiazole moiety of thiamin (vitamin B1) in higher plant chloroplasts. Proc Natl Acad Sci 88(6):2042–2045. https://doi.org/10.1073/pnas.88.6.2042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Wang C, Jang HJ, Cha MS, Park JE, Jo SY, Choi ES, Kim SW (2016) Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts. Microb Cell Fact 15:214. https://doi.org/10.1186/s12934-016-0612-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kozak BU, van Rossum HM, Benjamin KR, Wu L, Daran JM, Pronk JT, van Maris AJ (2014) Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis. Metab Eng 21:46–59. https://doi.org/10.1016/j.ymben.2013.11.005

Article  CAS  PubMed  Google Scholar 

Kumar P, Jun HB, Kim BS (2018) Co-production of polyhydroxyalkanoates and carotenoids through bioconversion of glycerol by Paracoccus sp. strain LL1. Int J Biol Macromol 107(Pt B):2552–2558. https://doi.org/10.1016/j.ijbiomac.2017.10.147

Article  CAS  PubMed  Google Scholar 

Li M, Chen H, Liu C, Guo J, Xu X, Zhang H, Nian R, Xian M (2019) Improvement of isoprene production in Escherichia coli by rational optimization of RBSs and key enzymes screening. Microb Cell Fact 18(1):4. https://doi.org/10.1186/s12934-018-1051-3

Article  PubMed  PubMed Central  Google Scholar 

Li M, Hou F, Wu T, Jiang X, Li F, Liu H, Xian M, Zhang H (2020a) Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories. Nat Prod Rep 37(1):80–99. https://doi.org/10.1039/c9np00016j

Article  CAS  PubMed  Google Scholar 

Li M, Nian R, Xian M, Zhang H (2018) Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli. Appl Microbiol Biotechnol 102:7725–7738. https://doi.org/10.1007/s00253-018-9200-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Xia Q, Lv S, Tong J, Wang Z, Nie Q, Yang J (2022) Enhanced CO2 capture for photosynthetic lycopene production in engineered Rhodopseudomonas palustris, a purple nonsulfur bacterium. Green Chem 24(19):7500–7518. https://doi.org/10.1039/D2GC02467E

Article  CAS  Google Scholar 

Li M, Xia Q, Zhang H, Zhang R, Yang J (2020b) Metabolic engineering of different microbial hosts for lycopene production. J Agric Food Chem 68(48):14104–14122. https://doi.org/10.1021/acs.jafc.0c06020

Article  CAS  Google Scholar 

Liang Q, Qi Q (2014) From a co-production design to an integrated single-cell biorefinery. Biotechnol Adv 32(7):1328–1335. https://doi.org/10.1016/j.biotechadv.2014.08.004

Article  CAS  PubMed  Google Scholar 

Liu W, Xu X, Zhang R, Cheng T, Cao Y, Li X, Guo J, Liu H, Xian M (2016) Engineering Escherichia coli for high-yield geraniol production with biotransformation of geranyl acetate to geraniol under fed-batch culture. Biotechnol Biofuels 9:58. https://doi.org/10.1186/s13068-016-0466-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, Wang YT (2012) Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae–a review. J Ethnopharmacol 143(2):406–411. https://doi.org/10.1016/j.jep.2012.07.009

Article  CAS  PubMed  Google Scholar 

Maury J, Asadollahi MA, Møller K, Clark A, Nielsen J (2005) Microbial isoprenoid production: an example of green chemistry through metabolic engineering. In: Nielsen J (ed) Biotechnology for the Future. Springer Berlin Heidelberg, Berlin, pp 19–51

Chapter  Google Scholar 

Meadows AL, Hawkins KM, Tsegaye Y, Antipov E, Kim Y, Raetz L, Dahl RH, Tai A, Mahatdejkul-Meadows T, Xu L, Zhao L, Dasika MS, Murarka A, Lenihan J, Eng D, Leng JS, Liu C-L, Wenger JW, Jiang H, Chao L, Westfall P, Lai J, Ganesan S, Jackson P, Mans R, Platt D, Reeves CD, Saija PR, Wichmann G, Holmes VF, Benjamin K, Hill PW, Gardner TS, Tsong AE (2016) Rewriting yeast central carbon metabolism for industrial isoprenoid production. Nature 537(7622):694–697. https://doi.org/10.1038/nature19769

Article  CAS  PubMed  Google Scholar 

Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Jiang H, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD (2013) High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496(7446):528–532. https://doi.org/10.1038/nature12051

Article