Huxley, A. F. & Stampfli, R. Evidence for saltatory conduction in peripheral myelinated nerve fibres. J. Physiol. 108, 315–339 (1949).
PubMed PubMed Central Google Scholar
Funfschilling, U. et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 485, 517–521 (2012).
PubMed PubMed Central Google Scholar
Bergles, D. E. & Richardson, W. D. Oligodendrocyte development and plasticity. Cold Spring Harb. Perspect. Biol. 8, a020453 (2015).
Hughes, E. G., Orthmann-Murphy, J. L., Langseth, A. J. & Bergles, D. E. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat. Neurosci. 21, 696–706 (2018). This study demonstrated that sensory stimulation can increase oligodendrogenesis and myelin internode formation in the superficial somatosensory cortex.
CAS PubMed PubMed Central Google Scholar
Czopka, T., Ffrench-Constant, C. & Lyons, D. A. Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Dev. Cell 25, 599–609 (2013).
CAS PubMed PubMed Central Google Scholar
Yalcin, B. & Monje, M. Microenvironmental interactions of oligodendroglial cells. Dev. Cell 56, 1821–1832 (2021).
CAS PubMed PubMed Central Google Scholar
Zuchero, J. B. & Barres, B. A. Intrinsic and extrinsic control of oligodendrocyte development. Curr. Opin. Neurobiol. 23, 914–920 (2013).
CAS PubMed PubMed Central Google Scholar
Pajevic, S., Basser, P. J. & Fields, R. D. Role of myelin plasticity in oscillations and synchrony of neuronal activity. Neuroscience 276, 135–147 (2014).
Scholz, J., Klein, M. C., Behrens, T. E. & Johansen-Berg, H. Training induces changes in white-matter architecture. Nat. Neurosci. 12, 1370–1371 (2009). This human neuroimaging study demonstrated microstructural changes in white matter regions relevant to hand–eye coordination after learning to juggle, suggesting motor learning-induced myelin plasticity.
CAS PubMed PubMed Central Google Scholar
Bengtsson, S. L. et al. Extensive piano practicing has regionally specific effects on white matter development. Nat. Neurosci. 8, 1148–1150 (2005).
Dziemian, S., Appenzeller, S., von Bastian, C. C., Jancke, L. & Langer, N. Working memory training effects on white matter integrity in young and older adults. Front. Hum. Neurosci. 15, 605213 (2021).
PubMed PubMed Central Google Scholar
Schiller, R. M. et al. Training-induced white matter microstructure changes in survivors of neonatal critical illness: a randomized controlled trial. Dev. Cogn. Neurosci. 38, 100678 (2019).
PubMed PubMed Central Google Scholar
Hofstetter, S., Tavor, I., Tzur Moryosef, S. & Assaf, Y. Short-term learning induces white matter plasticity in the fornix. J. Neurosci. 33, 12844–12850 (2013).
CAS PubMed PubMed Central Google Scholar
Alexander, D. C., Dyrby, T. B., Nilsson, M. & Zhang, H. Imaging brain microstructure with diffusion MRI: practicality and applications. NMR Biomed. 32, e3841 (2019).
Barres, B. A. & Raff, M. C. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature 361, 258–260 (1993).
Demerens, C. et al. Induction of myelination in the central nervous system by electrical activity. Proc. Natl Acad. Sci. USA 93, 9887–9892 (1996).
CAS PubMed PubMed Central Google Scholar
Stevens, B., Porta, S., Haak, L. L., Gallo, V. & Fields, R. D. Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 36, 855–868 (2002).
CAS PubMed PubMed Central Google Scholar
Gibson, E. M. et al. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science 344, 1252304 (2014). In this study, in vivo optogenetic studies provided direct evidence that cortical projection neuronal activity promotes circuit-specific OPC proliferation, oligodendrogenesis and myelination, specifically in corticocallosal — but not corticospinal — projections of the premotor circuit; changes in motor behavioural performance depended on these oligodendroglial changes.
PubMed PubMed Central Google Scholar
Mitew, S. et al. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Nat. Commun. 9, 306 (2018). Chemogenetic stimulation of somatosensory axons stimulates OPC proliferation, oligodendrogenesis and increased myelination of the stimulated axons, while chemogenetic inhibition of axonal activity exerted opposite effects, demonstrating selective myelination of more active axons and bidirectional myelin plasticity.
PubMed PubMed Central Google Scholar
Makinodan, M., Rosen, K. M., Ito, S. & Corfas, G. A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science 337, 1357–1360 (2012). This study demonstrated that social isolation decreases prefrontal cortex myelination. If social isolation occurred during a critical period in adolescence, this deficit in prefrontal cortex myelination was irreversible upon social reintegration.
CAS PubMed PubMed Central Google Scholar
Liu, J. et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat. Neurosci. 15, 1621–1623 (2012).
CAS PubMed PubMed Central Google Scholar
Mensch, S. et al. Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nat. Neurosci. 18, 628–630 (2015). This study showed that synaptic vesicle release modulates axon selection during development in zebrafish.
CAS PubMed PubMed Central Google Scholar
Hines, J., Ravanelli, A., Schwindt, R., Scott, E. & Appel, B. Neuronal activity biases axon selection for myelination in vivo. Nat. Neurosci. 18, 683–689 (2015).
CAS PubMed PubMed Central Google Scholar
McKenzie, I. A. et al. Motor skill learning requires active central myelination. Science 346, 318–322 (2014). This study demonstrated that new oligodendrocyte generation is required for motor learning.
CAS PubMed PubMed Central Google Scholar
Xiao, L. et al. Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nat. Neurosci. 19, 1210–1217 (2016).
CAS PubMed PubMed Central Google Scholar
Sampaio-Baptista, C. et al. Motor skill learning induces changes in white matter microstructure and myelination. J. Neurosci. 33, 19499–19503 (2013).
CAS PubMed PubMed Central Google Scholar
Steadman, P. E. et al. Disruption of oligodendrogenesis impairs memory consolidation in adult mice. Neuron 105, 150–164.e6 (2020). This study demonstrated that generation of new oligodendrocytes is required for spatial and fear memory consolidation, and provided experimental evidence that myelin plasticity promotes oscillatory synchrony between the hippocampus and frontal cortex.
Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R. & Kheirbek, M. A. Preservation of a remote fear memory requires new myelin formation. Nat. Neurosci. 23, 487–499 (2020).
CAS PubMed PubMed Central Google Scholar
Geraghty, A. C. et al. Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment. Neuron 103, 250–265.e8 (2019). This study demonstrated that activity-regulated BDNF signalling to TrkB in OPCs is required for activity-regulated OPC proliferation, oligodendrogenesis and myelination in cortical projection neurons, and that impaired myelin plasticity contributes to CRCI in mice.
CAS PubMed PubMed Central Google Scholar
Yang, S. M., Michel, K., Jokhi, V., Nedivi, E. & Arlotta, P. Neuron class-specific responses govern adaptive myelin remodeling in the neocortex. Science 370, eabd2109 (2020).
CAS PubMed PubMed Central Google Scholar
Tomassy, G. S. et al. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science 344, 319–324 (2014). This study demonstrated that cortical axons are discontinuously myelinated, illustrating that axonal territory is available for activity-regulated addition of myelin internodes.
CAS PubMed PubMed Central Google Scholar
Jito, J. et al. Maturational changes in diffusion anisotropy in the rat corpus callosum: comparison with quantitative histological evaluation. J. Magn. Reson. Imaging 28, 847–854 (2008).
Hughes, E. G., Kang, S. H., Fukaya, M. & Bergles, D. E. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat. Neurosci. 16, 668–676 (2013).
CAS PubMed PubMed Central Google Scholar
Hill, R. A., Li, A. M. & Grutzendler, J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nat. Neurosci. 21, 683–695 (2018).
CAS PubMed PubMed Central Google Scholar
Tripathi, R. B. et al. Remarkable stability of myelinating oligodendrocytes in mice. Cell Rep. 21, 316–323 (2017).
CAS PubMed PubMed Central Google Scholar
Hughes, A. N. & Appel, B. Microglia phagocytose myelin sheaths to modify developmental myelination. Nat. Neurosci. 23, 1055–1066 (2020).
CAS PubMed PubMed Central Google Scholar
Stevens, B. et al. The classical complement cascade mediates CNS synapse elimination. Cell 131, 1164–1178 (2007).
Schafer, D. P. et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691–705 (2012).
CAS PubMed PubMed Central Google Scholar
Swire, M., Kotelevtsev, Y., Webb, D. J., Lyons, D. A. & Ffrench-Constant, C. Endothelin signalling mediates experience-dependent myelination in the CNS. Elife 8, e49493 (2019). This study demonstrated that social experience-regulated myelination (the number of internodes per oligodendrocyte) is mediated by endothelin signalling from cerebral vessels to oligodendroglial endothelin B receptor in the superficial medial prefrontal cortex.
PubMed PubMed Central Google Scholar
Osso, L. A., Rankin, K. A. & Chan, J. R. Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin. Neuron 109, 3619–3632.e5 (2021).
Bergles, D. E., Roberts, J. D., Somogyi, P. & Jahr, C. E. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405, 187–191 (2000). This study demonstrated that electrophysiologically functional synapses e
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