Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment

Advancing on pancreatic cancer, Nat. Rev. Gastroenterol. Hepatol. (2021). https://doi.org/10.1038/s41575-021-00479-5

Article  Google Scholar 

J.D. Mizrahi, R. Surana, J.W. Valle and R.T. Shroff,Pancreatic cancer, Lancet (London, England) (2020). doi: https://doi.org/10.1016/s0140-6736(20)30974-0

R.L. Siegel, K.D. Miller, A. Jemal, Cancer statistics, 2020. CA Cancer J. Clin. (2020). https://doi.org/10.3322/caac.21590

Article  PubMed  Google Scholar 

The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol. Hepatol. (2019). doi: https://doi.org/10.1016/s2468-1253(19)30347-4

B. Uzunparmak, I.H. Sahin, Pancreatic cancer microenvironment: a current dilemma. Clin Transl Med (2019). https://doi.org/10.1186/s40169-019-0221-1

Article  PubMed  PubMed Central  Google Scholar 

F. Puleo, R. Nicolle, Y. Blum, J. Cros, L. Marisa, P. Demetter, E. Quertinmont, M. Svrcek, N. Elarouci, J. Iovanna, D. Franchimont, L. Verset, M.G. Galdon, J. Devière, A. de Reyniès, P. Laurent-Puig, J.L. Van Laethem, J.B. Bachet, R. Maréchal, Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features. Gastroenterology (2018). https://doi.org/10.1053/j.gastro.2018.08.033

Article  PubMed  Google Scholar 

M.A. Tempero, M.P. Malafa, M. Al-Hawary, S.W. Behrman, A.B. Benson, D.B. Cardin, E.G. Chiorean, V. Chung, B. Czito, M. Del Chiaro, M. Dillhoff, T.R. Donahue, E. Dotan, C.R. Ferrone, C. Fountzilas, J. Hardacre, W.G. Hawkins, K. Klute, A.H. Ko, J.W. Kunstman, N. LoConte, A.M. Lowy, C. Moravek, E.K. Nakakura, A.K. Narang, J. Obando, P.M. Polanco, S. Reddy, M. Reyngold, C. Scaife, J. Shen, C. Vollmer, R.A. Wolff, B.M. Wolpin, B. Lynn and G.V. George,Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J. Nat. Comprehen. Cancer Network : JNCCN (2021). doi: https://doi.org/10.6004/jnccn.2021.0017

E.S. Christenson, E. Jaffee, N.S. Azad, Current and emerging therapies for patients with advanced pancreatic ductal adenocarcinoma: a bright future. Lancet Oncol. (2020). https://doi.org/10.1016/s1470-2045(19)30795-8

Article  PubMed  PubMed Central  Google Scholar 

J.E. Murphy, J.Y. Wo, D.P. Ryan, J.W. Clark, W. Jiang, B.Y. Yeap, L.C. Drapek, L. Ly, C.V. Baglini, L.S. Blaszkowsky, C.R. Ferrone, A.R. Parikh, C.D. Weekes, R.D. Nipp, E.L. Kwak, J.N. Allen, R.B. Corcoran, D.T. Ting, J.E. Faris, A.X. Zhu, L. Goyal, D.L. Berger, M. Qadan, K.D. Lillemoe, N. Talele, R.K. Jain, T.F. DeLaney, D.G. Duda, Y. Boucher, C. Fernández-Del Castillo and T.S. Hong,Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. JAMA Oncol. (2019). doi: https://doi.org/10.1001/jamaoncol.2019.0892

D.P.S. Sohal, E.B. Kennedy, A. Khorana, M.S. Copur, C.H. Crane, I. Garrido-Laguna, S. Krishnamurthi, C. Moravek, E.M. O’Reilly, P.A. Philip, R.K. Ramanathan, J.T. Ruggiero, M.A. Shah, S. Urba, H.E. Uronis, M.W. Lau, D. Laheru, Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update, Journal of clinical oncology : official journal of the American Society of. Clin. Oncol. (2018). https://doi.org/10.1200/jco.2018.78.9636

Article  Google Scholar 

C. Pan, H. Liu, E. Robins, W. Song, D. Liu, Z. Li, L. Zheng, Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy. J. Hematol. Oncol. (2020). https://doi.org/10.1186/s13045-020-00862-w

Article  PubMed  PubMed Central  Google Scholar 

S. Yu, C. Zhang, K.P. Xie, Therapeutic resistance of pancreatic cancer: Roadmap to its reversal. Biochim. Biophys. Acta Rev. Cancer (2021). https://doi.org/10.1016/j.bbcan.2020.188461

Article  PubMed  Google Scholar 

W.J. Ho, E.M. Jaffee, L. Zheng, The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities. Nat. Rev. Clin. Oncol. (2020). https://doi.org/10.1038/s41571-020-0363-5

Article  PubMed  PubMed Central  Google Scholar 

J.P. Neoptolemos, J. Kleeff, P. Michl, E. Costello, W. Greenhalf, D.H. Palmer, Therapeutic developments in pancreatic cancer: current and future perspectives. Nat. Rev. Gastroenterol. Hepatol. (2018). https://doi.org/10.1038/s41575-018-0005-x

Article  PubMed  Google Scholar 

S.L. Topalian, J.M. Taube, R.A. Anders, D.M. Pardoll, Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat. Rev. Cancer (2016). https://doi.org/10.1038/nrc.2016.36

Article  PubMed  PubMed Central  Google Scholar 

L. Zheng, J. Xue, E.M. Jaffee, A. Habtezion, Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. Gastroenterology (2013). https://doi.org/10.1053/j.gastro.2012.12.042

Article  PubMed  PubMed Central  Google Scholar 

P. Zhao, L. Li, X. Jiang, Q. Li, Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy. J. Hematol. Oncol. (2019). https://doi.org/10.1186/s13045-019-0738-1

Article  PubMed  PubMed Central  Google Scholar 

B. Ren, M. Cui, G. Yang, H. Wang, M. Feng, L. You, Y. Zhao, Tumor microenvironment participates in metastasis of pancreatic cancer. Mol. Cancer (2018). https://doi.org/10.1186/s12943-018-0858-1

Article  PubMed  PubMed Central  Google Scholar 

A.S. Bear, R.H. Vonderheide, M.H. O’Hara, Challenges and Opportunities for Pancreatic Cancer Immunotherapy. Cancer Cell (2020). https://doi.org/10.1016/j.ccell.2020.08.004

Article  PubMed  PubMed Central  Google Scholar 

L.A. Rojas, V.P. Balachandran, Scaling the immune incline in PDAC. Nat. Rev. Gastroenterol. Hepatol. (2021). https://doi.org/10.1038/s41575-021-00475-9

Article  PubMed  PubMed Central  Google Scholar 

A. Dongre, R.A. Weinberg, Leveraging immunochemotherapy for treating pancreatic cancer. Cell Res. (2021). https://doi.org/10.1038/s41422-021-00574-x

Article  PubMed  Google Scholar 

M. Binnewies, E.W. Roberts, K. Kersten, V. Chan, D.F. Fearon, M. Merad, L.M. Coussens, D.I. Gabrilovich, S. Ostrand-Rosenberg, C.C. Hedrick, R.H. Vonderheide, M.J. Pittet, R.K. Jain, W. Zou, T.K. Howcroft, E.C. Woodhouse, R.A. Weinberg, M.F. Krummel, Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat. Med. (2018). https://doi.org/10.1038/s41591-018-0014-x

Article  PubMed  PubMed Central  Google Scholar 

L. Lin, Y.S. Chen, Y.D. Yao, J.Q. Chen, J.N. Chen, S.Y. Huang, Y.J. Zeng, H.R. Yao, S.H. Zeng, Y.S. Fu, E.W. Song, CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer. Oncotarget (2015). https://doi.org/10.18632/oncotarget.5325

Article  PubMed  PubMed Central  Google Scholar 

E. Hessmann, S.M. Buchholz, I.E. Demir, S.K. Singh, T.M. Gress, V. Ellenrieder, A. Neesse, Microenvironmental Determinants of Pancreatic Cancer. Physiol. Rev. (2020). https://doi.org/10.1152/physrev.00042.2019

Article  PubMed  Google Scholar 

D.C. Hinshaw, L.A. Shevde, The Tumor Microenvironment Innately Modulates Cancer Progression. Cancer Res (2019). https://doi.org/10.1158/0008-5472.Can-18-3962

Article  PubMed  PubMed Central  Google Scholar 

K.E. de Visser, A. Eichten, L.M. Coussens, Paradoxical roles of the immune system during cancer development. Nat. Rev. Cancer (2006). https://doi.org/10.1038/nrc1782

Article  PubMed  Google Scholar 

D. Hanahan, Hallmarks of Cancer: New Dimensions. Cancer Discov. (2022). https://doi.org/10.1158/2159-8290.Cd-21-1059

Article  PubMed  Google Scholar 

A.C. Hopkins, M. Yarchoan, J.N. Durham, E.C. Yusko, J.A. Rytlewski, H.S. Robins, D.A. Laheru, D.T. Le, E.R. Lutz, E.M. Jaffee, T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma. JCI Insight (2018). https://doi.org/10.1172/jci.insight.122092

Article  PubMed  PubMed Central  Google Scholar 

S.K. Dougan,The Pancreatic Cancer Microenvironment. Cancer J. (Sudbury, Mass.) (2017). doi: https://doi.org/10.1097/ppo.0000000000000288

E. Karamitopoulou, Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features. Br. J. Cancer (2019). https://doi.org/10.1038/s41416-019-0479-5

Article  PubMed  PubMed Central  Google Scholar 

E.A. Collisson, A. Sadanandam, P. Olson, W.J. Gibb, M. Truitt, S. Gu, J. Cooc, J. Weinkle, G.E. Kim, L. Jakkula, H.S. Feiler, A.H. Ko, A.B. Olshen, K.L. Danenberg, M.A. Tempero, P.T. Spellman, D. Hanahan, J.W. Gray, Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. (2011). https://doi.org/10.1038/nm.2344

Article  PubMed  PubMed Central  Google Scholar 

P. Bailey, D.K. Chang, K. Nones, A.L. Johns, A.M. Patch, M.C. Gingras, D.K. Miller, A.N. Christ, T.J. Bruxner, M.C. Quinn, C. Nourse, L.C. Murtaugh, I. Harliwong, S. Idrisoglu, S. Manning, E. Nourbakhsh, S. Wani, L. Fink, O. Holmes, V. Chin, M.J. Anderson, S. Kazakoff, C. Leonard, F. Newell, N. Waddell, S. Wood, Q. Xu, P.J. Wilson, N. Cloonan, K.S. Kassahn, D. Taylor, K. Quek, A. Robertson, L. Pantano, L. Mincarelli, L.N. Sanchez, L. Evers, J. Wu, M. Pinese, M.J. Cowley, M.D. Jones, E.K. Colvin, A.M. Nagrial, E.S. Humphrey, L.A. Chantrill, A. Mawson, J. Humphris, A. Chou, M. Pajic, C.J. Scarlett, A.V. Pinho, M. Giry-Laterriere, I. Rooman, J.S. Samra, J.G. Kench, J.A. Lovell, N.D. Merrett, C.W. Toon, K. Epari, N.Q. Nguyen, A. Barbour, N. Zeps, K. Moran-Jones, N.B. Jamieson, J.S. Graham, F. Duthie, K. Oien, J. Hair, R. Grützmann, A. Maitra, C.A. Iacobuzio-Donahue, C.L. Wolfgang, R.A. Morgan, R.T. Lawlor, V. Corbo, C. Bassi, B. Rusev, P. Capelli, R. Salvia, G. Tortora, D. Mukhopadhyay, G.M. Petersen, D.M. Munzy, W.E. Fisher, S.A. Karim, J.R. Eshleman, R.H. Hruban, C. Pilarsky, J.P. Morton, O.J. Sansom, A. Scarpa, E.A. Musgrove, U.M. Bailey, O. Hofmann, R.L. Sutherland, D.A. Wheeler, A.J. Gill, R.A. Gibbs, J.V. Pearson, N. Waddell, A.V. Biankin, S.M. Grimmond, Genomic analyses identify molecular subtypes of pancreatic cancer. Nature (2016). https://doi.org/10.1038/nature16965

Article  PubMed  PubMed Central  Google Scholar 

L. Cao, C. Huang, D. Cui Zhou, Y. Hu, T.M. Lih, S.R. Savage, K. Krug, D.J. Clark, M. Schnaubelt, L. Chen, F. da Veiga Leprevost, R.V. Eguez, W. Yang, J. Pan, B. Wen, Y. Dou, W. Jiang, Y. Liao, Z. Shi, N.V. Terekhanova, S. Cao, R.J. Lu, Y. Li, R. Liu, H. Zhu, P. Ronning, Y. Wu, M.A. Wyczalkowski, H. Easwaran, L. Danilova, A.S. Mer, S. Yoo, J.M. Wang, W. Liu, B. Haibe-Kains, M. Thiagarajan, S.D. Jewell, G. Hostetter, C.J. Newton, Q.K. Li, M.H. Roehrl, D. Fenyö, P. Wang, A.I. Nesvizhskii, D.R. Mani, G.S. Omenn, E.S. Boja, M. Mesri, A.I. Robles, H. Rodriguez, O.F. Bathe, D.W. Chan, R.H. Hruban, L. Ding, B. Zhang and H. Zhang,Proteogenomic characterization of pancreatic ductal adenocarcinoma, Cell (2021). doi: https://doi.org/10.1016/j.cell.2021.08.023

E.D. Thompson, N.J. Roberts, L.D. Wood, J.R. Eshleman, M.G. Goggins, S.E. Kern, A.P. Klein, R.H. Hruban, The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go. Modern Pathol. (2020). https://doi.org/10.1038/s41379-020-0629-6

Article  Google Scholar 

A. Hayashi, J. Hong, C.A. Iacobuzio-Donahue, The pancreatic cancer genome revisited. Nat. Rev. Gastroenterol. Hepatol. (2021). https://doi.org/10.1038/s41575-021-00463-z

Article  PubMed  Google Scholar 

L. Danilova, W.J. Ho, Q. Zhu, T. Vithayathil, A. De Jesus-Acosta, N.S. Azad, D.A. Laheru, E.J. Fertig, R. Anders, E.M. Jaffee, M. Yarchoan, Programmed Cell Death Ligand-1 (PD-L1) and CD8 Expression Profiling Identify an Immunologic Subtype of Pancreatic Ductal Adenocarcinomas with Favorable Survival. Cancer Immunol. Res. (2019). https://doi.org/10.1158/2326-6066.Cir-18-0822

Article  PubMed  PubMed Central  Google Scholar 

T.J. Li, W.Q. Wang, X.J. Yu, L. Liu, Killing the “BAD”: Challenges for immunotherapy in pancreatic cancer, Biochimica et biophysica acta. Rev. Cancer (2020). https://doi.org/10.1016/j.bbcan.2020.188384

Article  Google Scholar 

H. Liu, Y. Shi, F. Qian, Opportunities and delusions regarding drug delivery targeting pancreatic cancer-associated fibroblasts. Adv. Drug Deliv. Rev. (2021). https://doi.org/10.1016/j.addr.2021.02.012

Article  PubMed  PubMed Central  Google Scholar 

C. Zeltz, I. Primac, P. Erusappan, J. Alam, A. Noel, D. Gullberg, Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins. Semin. Cancer Biol. (2020). https://doi.org/10.1016/j.semcancer.2019.08.004

Article 

留言 (0)

沒有登入
gif