Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. NeuroImage, 38(1), 95–113. https://doi.org/10.1016/j.neuroimage.2007.07.007

Article  PubMed  Google Scholar 

Barć, K., Szacka, K., Nieporęcki, K., de Carvalho, M., Gromicho, M., Grosskreutz, J., Petri, S., Rödiger, A., Steinbach, R., Uysal, H., & Kuźma-Kozakiewicz, M. (2020). Emotional lability at disease onset is an independent prognostic factor of faster disease progression in amyotrophic lateral sclerosis. Aging and Disease, 11(5), 1021–1028. https://doi.org/10.14336/AD.2019.1120

Article  PubMed  PubMed Central  Google Scholar 

Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. (1996). Comparison of beck depression inventories -IA and -II in psychiatric outpatients. Journal of Personality Assessment, 67, 588–597. https://doi.org/10.1207/s15327752jpa6703_13

Article  PubMed  CAS  Google Scholar 

Bede, P., & Finegan, E. (2018). Revisiting the pathoanatomy of pseudobulbar affect: Mechanisms beyond corticobulbar dysfunction. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 19(1–2), 4–6. https://doi.org/10.1080/21678421.2017.1392578

Article  Google Scholar 

Bede, P., Chipika, R. H., Christidi, F., Hengeveld, J. C., Karavasilis, E., Argyropoulos, G. D., Lope, J., Li Hi Shing, S., Velonakis, G., Dupuis, L., Doherty, M. A., Vajda, A., McLaughlin, R. L., & Hardiman, O. (2021). Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations. Journal of Neurology, Neurosurgery, and Psychiatry, 92(11), 1197–1205. https://doi.org/10.1136/jnnp-2021-326854

Article  PubMed  Google Scholar 

Bodensteiner, J. B. (2018). Pseudobulbar affect in survivors of extreme prematurity with cerebellar injury: support for the cerebellar link in pathologic laughter and crying. Seminars in Pediatric Neurology, 26, 74–76. https://doi.org/10.1016/j.spen.2017.03.010

Article  PubMed  Google Scholar 

Brooks, B. R., Miller, R. G., Swash, M., Munsat, T. L., & World Federation of Neurology Research Group on Motor Neuron Diseases. (2000). El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 1(5), 293–299. https://doi.org/10.1080/146608200300079536

Article  PubMed  CAS  Google Scholar 

Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., & Nakanishi, A. (1999). The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). Journal of the Neurological Sciences, 169(1–2), 13–21. https://doi.org/10.1016/s0022-510x(99)00210-5

Article  PubMed  CAS  Google Scholar 

Chiò, A., Calvo, A., Moglia, C., Mazzini, L., Mora, G., & PARALS study group. (2011). Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population-based study. Journal of Neurology, Neurosurgery, and Psychiatry, 82(7), 740–746. https://doi.org/10.1136/jnnp.2010.235952

Article  PubMed  Google Scholar 

Christidi, F., Karavasilis, E., Ferentinos, P., Xirou, S., Velonakis, G., Rentzos, M., Zouvelou, V., Zalonis, I., Efstathopoulos, E., Kelekis, N., & Evdokimidis, I. (2018). Investigating the neuroanatomical substrate of pathological laughing and crying in amyotrophic lateral sclerosis with multimodal neuroimaging techniques. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 19(1–2), 12–20. https://doi.org/10.1080/21678421.2017.1386689

Article  Google Scholar 

Dark, F. L., McGrath, J. J., & Ron, M. A. (1996). Pathological laughing and crying. The Australian and New Zealand Journal of Psychiatry, 30(4), 472–479. https://doi.org/10.3109/00048679609065020

Article  PubMed  CAS  Google Scholar 

Eklund, A., Nichols, T. E., & Knutsson, H. (2016). Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. Proceedings of the National Academy of Sciences of the United States of America, 113(28), 7900–7905. https://doi.org/10.1073/pnas.1602413113

Article  PubMed  PubMed Central  CAS  Google Scholar 

Esposito, F., Scarabino, T., Hyvarinen, A., Himberg, J., Formisano, E., Comani, S., Tedeschi, G., Goebel, R., Seifritz, E., & Di Salle, F. (2005). Independent component analysis of fMRI group studies by self-organizing clustering. NeuroImage, 25(1), 193–205. https://doi.org/10.1016/j.neuroimage.2004.10.042

Article  PubMed  Google Scholar 

Finegan, E., Chipika, R. H., Li Hi Shing, S., Hardiman, O., & Bede, P. (2019). Pathological crying and laughing in motor neuron disease: Pathobiology, screening, intervention. Frontiers in neurology, 10, 260. https://doi.org/10.3389/fneur.2019.00260

Article  PubMed  PubMed Central  Google Scholar 

Finegan, E., Shing, S. L. H., Chipika, R. H., Chang, K. M., McKenna, M. C., Doherty, M. A., Hengeveld, J. C., Vajda, A., Pender, N., Donaghy, C., Hutchinson, S., McLaughlin, R. L., Hardiman, O., & Bede, P. (2021). Extra-motor cerebral changes and manifestations in primary lateral sclerosis. Brain Imaging Behavior, 15, 2283–2296. https://doi.org/10.1007/s11682-020-00421-4

Article  PubMed  Google Scholar 

Floeter, M. K., Katipally, R., Kim, M. P., Schanz, O., Stephen, M., Danielian, L., Wu, T., Huey, E. D., & Meoded, A. (2014). Impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron disorders. Neurology, 83(7), 620–627. https://doi.org/10.1212/WNL.0000000000000693

Article  PubMed  PubMed Central  Google Scholar 

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. https://doi.org/10.1016/0022-3956(75)90026-6

Article  PubMed  CAS  Google Scholar 

Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995). Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold. Magnetic Resonance in Medicine, 33(5), 636–647. https://doi.org/10.1002/mrm.1910330508

Article  PubMed  CAS  Google Scholar 

Goebel, R., Esposito, F., & Formisano, E. (2006). Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: From single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Human Brain Mapping, 27(5), 392–401. https://doi.org/10.1002/hbm.20249

Article  PubMed  PubMed Central  Google Scholar 

Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007). Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry, 62(5), 429–437. https://doi.org/10.1016/j.biopsych.2006.09.020

Article  PubMed  PubMed Central  Google Scholar 

Henley, S. M., Ridgway, G. R., Scahill, R. I., Klöppel, S., Tabrizi, S. J., Fox, N. C., Kassubek, J., EHDN Imaging Working Group. (2010). Pitfalls in the use of voxel-based morphometry as a biomarker: examples from Huntington disease. AJNR. American Journal of Neuroradiology, 31(4), 711–719. https://doi.org/10.3174/ajnr.A1939

Article  PubMed  PubMed Central  CAS  Google Scholar 

Himberg, J., Hyvärinen, A., & Esposito, F. (2004). Validating the independent components of neuroimaging time series via clustering and visualization. NeuroImage, 22(3), 1214–1222. https://doi.org/10.1016/j.neuroimage.2004.03.027

Article  PubMed  Google Scholar 

Hübers, A., Kassubek, J., Grön, G., Gorges, M., Aho-Oezhan, H., Keller, J., Horn, H., Neugebauer, H., Uttner, I., Lulé, D., & Ludolph, A. C. (2016). Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function. Journal of Neurology, 263(9), 1788–1795. https://doi.org/10.1007/s00415-016-8201-5

Article  PubMed  Google Scholar 

Hyvärinen, A., Karhunen, J., & Oja, E. (2001). Independent component analysis. Wiley.

Book  Google Scholar 

King, R. R., & Reiss, J. P. (2013). The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration. Degenerative Neurological and Neuromuscular Disease, 3, 23–31. https://doi.org/10.2147/DNND.S34160

Article  PubMed  PubMed Central  Google Scholar 

Klingbeil, J., Wawrzyniak, M., Stockert, A., Brandt, M. L., Schneider, H. R., Metelmann, M., & Saur, D. (2021). Pathological laughter and crying: insights from lesion network-symptom-mapping. Brain: A Journal of Neurology, 144(10), 3264–3276. https://doi.org/10.1093/brain/awab224

Article  Google Scholar 

Lancaster, J. L., Tordesillas-Gutiérrez, D., Martinez, M., Salinas, F., Evans, A., Zilles, K., Mazziotta, J. C., & Fox, P. T. (2007). Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template. Human Brain Mapping, 28(11), 1194–1205. https://doi.org/10.1002/hbm.20345

Article  PubMed  PubMed Central  Google Scholar 

Lapchak, P. A. (2015). Neuronal dysregulation in stroke-associated pseudobulbar affect (PBA): Diagnostic scales and current treatment options. Journal of Neurology & Neurophysiology, 6(5), 323. https://doi.org/10.4172/2155-9562.1000323

Article  Google Scholar 

Malone, I. B., Leung, K. K., Clegg, S., Barnes, J., Whitwell, J. L., Ashburner, J., Fox, N. C., & Ridgway, G. R. (2015). Accurate automatic estimation of total intracranial volume: A nuisance variable with less nuisance. NeuroImage, 104, 366–372. https://doi.org/10.1016/j.neuroimage.2014.09.034

Article  PubMed  Google Scholar 

Moore, S. R., Gresham, L. S., Bromberg, M. B., Kasarkis, E. J., & Smith, R. A. (1997). A self report measure of affective lability. Journal of Neurology, Neurosurgery, and Psychiatry, 63(1), 89–93. https://doi.org/10.1136/jnnp.63.1.89

Article  PubMed  PubMed Central  CAS  Google Scholar 

Parvizi, J., Anderson, S. W., Martin, C. O., Damasio, H., & Damasio, A. R. (2001). Pathological laughter and crying: a link to the cerebellum. Brain: A Journal of Neurology, 124(Pt 9), 1708–1719. https://doi.org/10.1093/brain/124.9.1708

Article  CAS  Google Scholar 

Parvizi, J., Arciniegas, D. B., Bernardini, G. L., Hoffmann, M. W., Mohr, J. P., Rapoport, M. J., Schmahmann, J. D., Silver, J. M., & Tuhrim, S. (2006). Diagnosis and management of pathological laughter and crying. Mayo Clinic Proceedings, 81(11), 1482–1486. https://doi.org/10.4065/81.11.1482

Article  PubMed  Google Scholar 

Parvizi, J., Coburn, K. L., Shillcutt, S. D., Coffey, C. E., Lauterbach, E. C., & Mendez, M. F. (2009). Neuroanatomy of pathological laughing and crying: A report of the American Neuropsychiatric Association Committee on Research. The Journal of Neuropsychiatry and Clinical Neurosciences, 21(1), 75–87. https://doi.org/10.1176/jnp.2009.21.1.75

Article  PubMed  Google Scholar 

Poletti, B., Solca, F., Carelli, L., Madotto, F., Lafronza, A., Faini, A., Monti, A., Zago, S., Calini, D., Tiloca, C., Doretti, A., Verde, F., Ratti, A., Ticozzi, N., Abrahams, S., & Silani, V. (2016). The validation of the Italian Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 17(7–8), 489–498. https://doi.org/10.1080/21678421.2016.1183679

Article  Google Scholar 

Pollack, I. F.,