Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. Pain. 2010;149(3):573–81.

Article  PubMed  Google Scholar 

Pujol J, Martínez-Vilavella G, Llorente-Onaindia J, Harrison BJ, López-Solà M, López-Ruiz M, Blanco-Hinojo L, Benito P, Deus J, Monfort J. Brain imaging of pain sensitization in patients with knee osteoarthritis. Pain. 2017;158(9):1831–8.

Article  PubMed  Google Scholar 

Clauw DJ. Fibromyalgia and related conditions. Mayo Clin Proc. 2015;90(5):680–92.

Article  PubMed  Google Scholar 

Kosek E, Cohen M, Baron R, Gebhart GF, Mico JA, Rice ASC, Rief W, Sluka AK. Do we need a third mechanistic descriptor for chronic pain states? Pain. 2016;157(7):1382–6.

Article  PubMed  Google Scholar 

International Association for the Study of Pain (IASP). IASP Terminology. Available online: https://www.iasp-pain.org/terminology?navItemNumber=576#Centralsensitization .Accessed on 28 Sept 2022.

Baliki MN, Mansour AR, Baria AT, Apkarian AV. Functional reorganization of the default mode network across chronic pain conditions. PLoS ONE. 2014;9(9):e106133.

Article  PubMed  PubMed Central  Google Scholar 

Barroso J, Wakaizumi K, Reis AM, Baliki M, Schnitzer TJ, Galhardo V, Apkarian AV. Reorganization of functional brain network architecture in chronic osteoarthritis pain. Hum Brain Mapp. 2021;42(4):1206–22.

Article  PubMed  Google Scholar 

Cottam WJ, Iwabuchi SJ, Drabek MM, Reckziegel D, Auer DP. Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. Pain. 2018;159(5):929–38.

Article  PubMed  PubMed Central  Google Scholar 

Davis DA, Ghantous ME, Farmer MA, Baria AT, Apkarian AV. Identifying brain nociceptive information transmission in patients with chronic somatic pain. Pain Rep. 2016;1(4):e575.

Article  PubMed  PubMed Central  Google Scholar 

Lan F, Lin G, Cao G, Li Z, Ma D, Liu F, Duan M, Fu H, Xiao W, Qi Z, Wang T. Altered intrinsic brain activity and functional connectivity before and after knee arthroplasty in the elderly: a resting-state fMRI study. Front Neurol. 2020;29(11):556028.

Article  Google Scholar 

Ushio K, Nakanishi K, Mikami Y, Yoshino A, Takamura M, Hirata K, Akiyama Y, Kimura H, Okamoto Y, Adachi N. Altered resting-state connectivity with pain-related expectation regions in female patients with severe knee osteoarthritis. J Pain Res. 2020;2(13):3227–34.

Google Scholar 

Ichesco E, Schmidt-Wilcke T, Bhavsar R, Clauw DJ, Peltier SJ, Kim J, Napadow V, Hampson JP, Kairys AE, Williams DA, Harris RE. Altered resting state connectivity of the insular cortex in individuals with fibromyalgia. J Pain. 2014;15(8):815-826.e1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cifre I, Sitges C, Fraiman D, Muñoz MÁ, Balenzuela P, González-Roldán A, Martínez-Jauand M, Birbaumer N, Chialvo DR, Montoya P. Disrupted functional connectivity of the pain network in fibromyalgia. Psychosom Med. 2012;74(1):55–62.

Article  PubMed  Google Scholar 

Kaplan CM, Schrepf A, Vatansever D, Larkin TE, Mawla I, Ichesco E, Kochlefl L, Harte SE, Clauw DJ, Mashour GA, Harris RE. Functional and neurochemical disruptions of brain hub topology in chronic pain. Pain. 2019;160(4):973–83.

Article  PubMed  PubMed Central  Google Scholar 

Kim J, Loggia ML, Cahalan CM, Harris RE, Beissner F, Garcia RG, Kim H, Wasan AD, Edwards RR, Napadow V. The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction. Arthritis Rheumatol. 2015;67(5):1395–405.

Article  PubMed  PubMed Central  Google Scholar 

Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum. 2010;62(8):2545–55.

Article  PubMed  PubMed Central  Google Scholar 

Macià D, Pujol J, Blanco-Hinojo L, Martínez-Vilavella G, Martín-Santos R, Deus J. Characterization of the spatial structure of local functional connectivity using multidistance average correlation measures. Brain Connect. 2018;8(5):276–87.

Article  PubMed  Google Scholar 

Blanco-Hinojo L, Pujol J, Macià D, Martínez-Vilavella G, Martín-Santos R, Pérez-Sola V, Deus J. Mapping the synchronization effect of gamma-aminobutyric acid inhibition on the cerebral cortex using magnetic resonance imaging. Brain Connect. 2021;11(5):393–403.

Article  PubMed  Google Scholar 

Pujol J, Blanco-Hinojo L, Macià D, Alonso P, Harrison BJ, Martínez-Vilavella G, Deus J, Menchón JM, Cardoner N, Soriano-Mas C. Mapping alterations of the functional structure of the cerebral cortex in obsessive-compulsive disorder. Cereb Cortex. 2019;29(11):4753–62.

Article  PubMed  Google Scholar 

Pujol J, Macià D, Garcia-Fontanals A, Blanco-Hinojo L, López-Solà M, Garcia-Blanco S, Poca-Dias V, Harrison BJ, Contreras-Rodríguez O, Monfort J, Garcia-Fructuoso F, Deus J. The contribution of sensory system functional connectivity reduction to clinical pain in fibromyalgia. Pain. 2014;155(8):1492–503.

Article  PubMed  Google Scholar 

Pujol J, Martínez-Vilavella G, Doreste A, Blanco-Hinojo L, Ojeda F, Llorente-Onaindia J, Polino L, Deus J, Monfort J. Tapentadol effects on brain response to pain in sensitized patients with knee osteoarthritis. Rheumatology (Oxford). 2022;61(6):2335–45.

Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039–49.

Article  CAS  PubMed  Google Scholar 

Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia .Report of the multicenter criteria committee. Arthritis Rheum. 1990;33(2):160–72.

Article  CAS  PubMed  Google Scholar 

Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol. 1991;18(5):728–33.

CAS  PubMed  Google Scholar 

Cleeland CS, Ryan KM. Pain assessment: global use of the brief pain inventory. Ann Acad Med Singap. 1994;23(2):129–38.

CAS  PubMed  Google Scholar 

Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833–40.

CAS  PubMed  Google Scholar 

De Andrés J, Pérez-Cajaraville J, Lopez-Alarcón MD, López-Millán JM, Margarit C, Rodrigo-Royo MD, Franco-Gay ML, Abejón D, Ruiz MA, López-Gomez V, Pérez M. Cultural adaptation and validation of the painDETECT scale into Spanish. Clin J Pain. 2012;28(3):243–53.

Article  PubMed  Google Scholar 

Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473–83.

Article  PubMed  Google Scholar 

Alonso J, Prieto L, Ferrer M, Vilagut G, Broquetas JM, Roca J, Batlle JS, Antó JM. Testing the measurement properties of the Spanish version of the SF-36 health survey among male patients with chronic obstructive pulmonary disease. Quality of life in COPD study group. J Clin Epidemiol. 1998;51(11):1087–94.

Article  CAS  PubMed  Google Scholar 

Quintana JM, Padierna A, Esteban C, Arostegui I, Bilbao A, Ruiz I. Evaluation of the psychometric characteristics of the Spanish version of the hospital anxiety and depression scale. Acta Psychiatr Scand. 2003;107(3):216–21.

Article  CAS  PubMed  Google Scholar 

Power JD, Mitra A, Laumann TO, Snyder AZ, Schlaggar BL, Petersen SE. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage. 2014;1(84):320–41.

Article  Google Scholar 

Desmond JE, Glover GH. Estimating sample size in functional MRI (fMRI) neuroimaging studies: statistical power analyses. J Neurosci Methods. 2002;118(2):115–28.

Article  PubMed  Google Scholar 

De Ridder D, Adhia D, Vanneste S. The anatomy of pain and suffering in the brain and its clinical implications. Neurosci Biobehav Rev. 2021;130:125–46.

Article  PubMed  Google Scholar 

Baliki MN, Schnitzer TJ, Bauer WR, Apkarian AV. Brain morphological signatures for chronic pain. PLoS ONE. 2011;6(10):e26010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alshuft HM, Condon LA, Dineen RA, Auer DP. Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain sensitization. PLoS ONE. 2016;11(9):e0161687.

Article  PubMed  PubMed Central  Google Scholar 

Guo H, Wang Y, Qiu L, Huang X, He C, Zhang J, Gong Q. Structural and functional abnormalities in knee osteoarthritis pain revealed with multimodal magnetic resonance imaging. Front Hum Neurosci. 2021;29(15):783355.

Article  Google Scholar 

Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum. 2010;62(10):2930–40.

Article  PubMed  Google Scholar 

Pedersini P, Gobbo M, Bishop MD, Arendt-Nielsen L, Villafañe JH. Functional and structural neuroplastic changes related to sensitization proxies in patients with osteoarthritis: a systematic review. Pain Med. 2022;23(3):488–98.

Article  PubMed  Google Scholar 

Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, May A. Structural brain changes in chronic pain reflect probably neither damage nor atrophy. PLoS ONE. 2013;8(2):e54475.

Article