Lenka Krskova and Michal Zapotocky authors contributed equally to this study

Prague Brain Tumor Research Group, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

Adela Misove, Ales Vicha, Katerina Vanova, David Sumerauer, Miroslav Koblizek, Josef Zamecnik, Lenka Krskova & Michal Zapotocky

Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova & Michal Zapotocky

Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University Prague and Faculty Hospital Motol, Prague, Czech Republic

Petr Broz, Miroslav Koblizek, Josef Zamecnik & Lenka Krskova

Department of Radiology, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic

Martin Kyncl & Zuzana Holubova

Department of Neurosurgery, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

Petr Liby, Jakub Taborsky & Vladimir Benes III

Department of Neurology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

Ivana Pernikova

Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany

David T. W. Jones

Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

David T. W. Jones

Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Martin Sill

Department of Pediatric Oncology and Hematology, Children’s University Hospital, Banska Bystrica, Slovakia

Terezia Stancokova