Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer

Conception and design: James T. Topham, Hagen F. Kennecke, Derek J. Jonker, Eric X. Chen, Jonathan M. Loree

Financial support: Jonathan M. Loree

Provision of study materials or patients: Hagen F. Kennecke, Derek J. Jonker, Eric X. Chen, Jonathan M. Loree

Collection and assembly of data: James T. Topham, Young S. Lee, Weimin Li, Katie Quinn, Daniel J. Renouf, Derek J. Jonker, Dongsheng Tu, Eric X. Chen, Jonathan M. Loree

Data analysis and interpretation: James T. Topham, Harriet Feilotter, Weimin Li, Kimberly C. Banks, Katie Quinn, Daniel J. Renouf, Derek J. Jonker, Dongsheng Tu, Eric X. Chen, Jonathan M. Loree

Manuscript writing: All authors

Final approval of manuscript: All authors

Accountable for all aspects of the work: All authors

AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.

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Harriet Feilotter

Honoraria: Janssen Diagnostics, Roche Canada, Precision RxDx, Bristol Myers Squibb, Diaceutics, Astellas Pharma, Bayer, EMD Serono, Novartis Canada Pharmaceuticals Inc, AstraZeneca, Pfizer

Consulting or Advisory Role: Janssen Diagnostics, Roche Canada, Precision RxDx, Astellas Pharma, Bayer

Speakers' Bureau: Bayer, EMD Serono, AstraZeneca

Research Funding: AstraZeneca (Inst), Bayer (Inst), EMD Serono (Inst), Delphi Diagnostics (Inst), Lilly (Inst), Amgen (Inst), Roche Canada (Inst)

Hagen F. Kennecke

Honoraria: Natera, Tersera, Novartis

Consulting or Advisory Role: Tersera

Speakers' Bureau: Natera

Research Funding: Taiho Pharmaceutical (Inst), Novartis (Inst), Exelixis (Inst)

Young S. Lee

Employment: AstraZeneca

Stock and Other Ownership Interests: AstraZeneca

Weimin Li

Employment: Overland Pharmaceuticals, Takeda

Stock and Other Ownership Interests: Overland Pharmaceuticals, Takeda

Kimberly C. Banks

Employment: Guardant Health

Stock and Other Ownership Interests: Guardant Health

Patents, Royalties, Other Intellectual Property: Guardant Health

Katie Quinn

Employment: Guardant Health

Stock and Other Ownership Interests: Guardant Health

Daniel J. Renouf

Honoraria: Roche, Bayer

Consulting or Advisory Role: Roche

Research Funding: Bayer (Inst), Roche (Inst)

Eric X. Chen

Honoraria: Eisai, Roche Canada, Bayer, AstraZeneca Canada, Ipsen

Research Funding: Merck Sharp & Dohme, AstraZeneca/MedImmune, Bristol Myers Squibb, Novartis, Mirati Therapeutics, Roche Canada, 1Globe Health Institute, Repare Therapeutics, Nubiyota

Jonathan M. Loree

Consulting or Advisory Role: Taiho Pharmaceutical, Ipsen, Novartis, Bayer, Amgen, Eisai, Pfizer

Research Funding: Ipsen (Inst), Amgen (Inst)

No other potential conflicts of interest were reported.

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